Narrative Review: Nano Kapsul Ekstrak Biji papaya (Carica Papaya L.) sebagai Antifertilitas

Narrative Review: Nano Capsules Papaya Seed Extract (Carica Papaya L.) as Antifertility

Authors

  • Shinta Nur Fajriyah Universitas Ahmad Dahlan
  • Yuliana Eka Lestari Universitas Ahmad Dahlan
  • Nadiatul Istiqamah Suaka Universitas Ahmad Dahlan
  • Endang Darmawan Universitas Ahmad Dahlan https://orcid.org/0000-0001-6143-4126

DOI:

https://doi.org/10.33084/jsm.v6i2.1688

Keywords:

Papaya seed extract, Nano capsule, Antifertility

Abstract

Papaya (Carica Papaya L.) is a plant commonly found in Indonesia. Interestingly, its seeds traditionally used as antifertility. All parts of the Carica Papaya tree can be used for human needs from the fruit, leaves, seeds, sap, and stems. Carica Papaya seed extract contains secondary metabolite compounds in class Triterpenoids, flavonoids, alkaloids, saponins, and tannins which have functioned as antifertility. Nanocapsule is an innovation of nanoparticle dosage form with small particle size, that can accelerate the drug to the target. This Narrative Review purposed to determine the usefulness of the nanocapsules of Carica Papaya seed extract as antifertility. This research is a Narrative Review. A total of 36 articles that met the inclusion and exclusion criteria were analyzed descriptively, which include the efficacy of Carica Papaya, nanocapsules, and antifertility. The articles used include articles published in national journals and international journals. The result of the Narrative Review is presented in descriptive form. The results of the research show that Carica Papaya can be used traditionally to treat skin diseases, diarrheal disease, overcoming digestive disorders, and by research can be used as antifertility, The size of the nanoparticles obtained in the study ranged from 76.47 nm to 693.8 nm, and Carica Papaya seed extract is used as an antifertility by reducing sperm quantity, semen pH, spermatogenesis process, interfering the action of pituitary gonads, by preclinical reducing the number of ovum quality and the number of de Graff Follicles in female mice. Overall, it can be concluded that Carica Papaya nanocapsules in particle sizes between 76.46 nm to 693.8 nm can be used as antifertility that preclinically can affect the reproduction of female and male mice.

Downloads

Download data is not yet available.

References

1. Fauziya, S., & Krishnamurthy, R. (2013). Papaya (Carica papaya): Source material for anticancer. CIBTech Journal of Pharmaceutical Sciences, 2(1), 25-34.
2. Pavithra, C. S., Devi, S. S., Suneetha, W. J., & Rani, C. V. D. (2017). Nutritional properties of papaya peel. The Pharma Innovation Journal, 6(7), 170-173.
3. Peter, J. K., Kumar, Y., Pandey, P., & Masih, H. (2014). Antibacterial activity of seed and leaf extract of Carica Papaya var. Pusa dwarf Linn. IOSR Journal of Pharmacy and Biological sciences, 9(2), 29-37.
4. Charan, J., Saxena, D., Goyal, J. P., & Yasobant, S. (2016). Efficacy and safety of Carica papaya leaf extract in the dengue: A systematic review and meta-analysis. International Journal of Applied and Basic Medical Research, 6(4), 249-254.
5. Satriyasa, B. K., Mahendra, A. N., Arijana, I. G. K., & Ruspawan, D. M. (2018). Unripe Papaya Seed Ethanol Extract (Carica Papaya, Linn.) Inhibits FSH and LH of Male Mice (Mus Musculus). Biomedical and Pharmacology Journal, 11(2), 979-984.
6. Rachmawati, A. L., & Surini, S. (2018). Formulasi dan Karakterisasi Nanopartikel Sambungsilang Gom Xantan dan Gom Akasia Untuk Penghantaran Insulin Oral. Pharmaceutical Sciences and Research (PSR), 5(3), 159-168.
7. Julianawati, T., Hendarto, H., & Widjiati. (2020). Penetapan Total Flavonoid, Aktivitas Antioksidan dan Karakterisasi Nanopartikel Ekstrak Etanol Daun Kelor (Moringa pterygosperma Gaertn.). Jurnal Penelitian Kesehatan" SUARA FORIKES"(Journal of Health Research" Forikes Voice"), 11(1), 49-54.
8. Martien, R., Adhyatmika, Irianto, I. D. K., Farida, V., & Sari, D. P. (2012). Perkembangan Teknologi Nanopartikel Sebagai Sistem Penghantaran Obat. Majalah Farmaseutik, 8(1), 133–144.
9. Dai, T., Tanaka, M., Huang, Y. Y., & Hamblin, M. R. (2011). Chitosan preparations for wounds and burns: antimicrobial and wound-healing effects. Expert review of anti-infective therapy, 9(7), 857-879.
10. Li, J., Cai, C., Li, J., Li, J., Li, J., Sun, T., Wang, L., Wu, H., & Yu, G. (2018). Chitosan-based nanomaterials for drug delivery. Molecules, 23(10), 2661.
11. Gan, Q., Wang, T., Cochrane, C., & McCarron, P. (2005). Modulation of surface charge particle size and morphological properties of chitosan–TPP nanoparticles intended for gene delivery. Colloids and Surfaces B: Biointerfaces, 44(2-3), 65-73.
12. Sreekumar, S., Goycoolea, F. M., Moerschbacher, B. M., & Rivera-Rodriguez, G. R. (2018). Parameters influencing the size of chitosan-TPP nano-and microparticles. Scientific reports, 8, 1-11.
13. Agada, R., Usman, W. A., Shehu, S., & Thagariki, D. (2020). In vitro and in vivo inhibitory effects of Carica papaya seed on α-amylase and α-glucosidase enzymes. Heliyon, 6(3).
14. Mappamasing, F., Anwar, E., & Mun’im, A. (2015). Formulasi, Karakterisasi dan Uji Penetrasi In Vitro Resveratrol Solid Lipid Nanopartikel dalam Krim Topikal. Jurnal Ilmu Kefarmasian Indonesia, 13(2), 137-144.
15. Ilhami, F. B. (2016). Efektifitas Nanopartikel Magnetik (MnFe2O4) Berlapis HSA Tertarget Reseptor Folat Terhadap Sel Kanker. Jurnal Biosains Pascasarjana, 18(2), 140-152.
16. Suryani., Musnina, W. O. S., & Anto, A. S. (2017). Optimasi Formula Matriks Patch Transdermal Nanopartikel Teofilin dengan Menggunakan Metode Simplex Lattice Design (SLD). Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan, 3(1), 26-32.
17. Trinanda, R., Sundaryono, A., & Handayani, D. (2019). PEMBUATAN NANOPARTIKEL-PERAK EKSTRAK DAUN UBI JALAR ORANGE (Ipomoea batatas L.) DENGAN METODE BIOREDUKSI DAN UJ AKTIVITAS TERHADAP JUMLAH TROMBOSIT Mus musculus. Alotrop, Jurnal Pendidikan Dan Ilmu Kimia, 3(1), 76-81.
18. Hecq, J., Siepmann, F., Siepmann, J., Amighi, K., & Goole, J. (2015). Development and evaluation of chitosan and chitosan derivative nanoparticles containing insulin for oral administration. Drug development and industrial pharmacy, 41(12), 2037-2044.
19. Kailaku, S. I., Mulyawanti, I., & Alamsyah, A. N. (2014). Formulation of nanoencapsulated catechin with chitosan as encapsulation material. Procedia chemistry, 9, 235-241.
20. Alfian, M. A. J., Sitasiwi, A. J., & Djaelani, M. A. (2018). Efek antifertilitas ekstrak air biji pepaya (carica papaya l.) terhadap jumlah dan diameter folikel de graaf mencit (mus musculus) betina. Pro-Life, 5(1), 476-486.
21. Rachmawati, H., Reker-Smit, C., Hooge, M.N.L., Loenen-Weemaes, A.M.V., Poelstra, K., Beljaars, L. 2007. Chemical Modification of Interleukin-10 with Mannose 6-Phosphate Groups Yield a Liver-Selective Cytokine. DMD, 35, 814-821.
22. Rahmat, D., & Salim, S. (2019). Uji Mukoadhesif Nanopartikel Crude Bromelin dari Perasan Bonggol Nanas Berbasis Hidroksi Propil Selulosa-Sisteamin. Majalah Farmasetika, 4, 113-118.

Downloads

Published

2021-02-15

How to Cite

Fajriyah, S. N., Lestari, Y. E., Suaka, N. I., & Darmawan, E. (2021). Narrative Review: Nano Kapsul Ekstrak Biji papaya (Carica Papaya L.) sebagai Antifertilitas: Narrative Review: Nano Capsules Papaya Seed Extract (Carica Papaya L.) as Antifertility. Jurnal Surya Medika (JSM), 6(2), 10–24. https://doi.org/10.33084/jsm.v6i2.1688

Most read articles by the same author(s)