@article{Hasim_Mantik_Husnawati_Priosoeryanto_Puspita_2022, place={Palangka Raya, Indonesia}, title={Antiproliferative Potency of God’s Crown Fruit (Phaleria macrocarpa) Extract Against Breast Cancer Cell}, volume={5}, url={https://journal.umpr.ac.id/index.php/bjop/article/view/2822}, DOI={10.33084/bjop.v5i4.2822}, abstractNote={<p style="text-align: justify;">Breast cancer is a sickness caused by abnormal cell growth in the breast. Mahkota Dewa fruit or god’s crown fruit products (<em>Phaleria macrocarpa</em>) contain flavonoids, alkaloids, polyphenols, and tannins associated with active compounds. This work directs to influence the potency of <em>P. macrocarpa</em> fruit as an antiproliferative agent against breast cancer cells (MCF-7 cells). The antiproliferative potency of <em>P. macrocarpa</em> fruit was proved by extracting and fractionating <em>P. macrocarpa</em> fruit using maceration. The cytotoxicity of extracts and fractions was determined using Brine Shrimp Lethality Test (BSLT). The antiproliferative potency against MCF-7 cells was tested using the hemacytometer approach. This work demonstrates the crude ethanol extract, <em>n</em>-hexane fraction, ethyl acetate fraction, and water fraction. The LC<sub>50</sub> values in crude ethanol extract, <em>n</em>-hexane fraction, ethyl acetate fraction, and water fraction were 13.72 ppm, 147.55 ppm, 405.81 ppm, and 149. 07 ppm severally. <em>Phaleria macrocarpa</em> fruit has shown antiproliferation potency against MCF-7 cells. The maximum part of crude ethanol extract antiproliferative potency (56 ppm) effectively suppressed MCF-7 cell growth by 70. 9% while doxorubicin (100 ppm) by 46. 92%. This work confirms that crude ethanol extract of <em>P. macrocarpa</em> fruit interacts synergistically as an antiproliferative compound against MCF-7 cells.</p>}, number={4}, journal={Borneo Journal of Pharmacy}, author={Hasim, Hasim and Mantik, Yonathan Arderian and Husnawati, Husnawati and Priosoeryanto, Bambang Pontjo and Puspita, Ratna}, year={2022}, month={Nov.}, pages={307–314} }