TY - JOUR AU - Riskianto, Riskianto AU - Windi, Melieta AU - Karnelasatri, Karnelasatri AU - Aruan, Maroloan PY - 2022/11/30 Y2 - 2024/03/28 TI - Antioxidant Activity of 96% Ethanol Extract of Pepaya Jepang Leaves (Cnidoscolus aconitifolius (Mill.) I. M. Johnst) Using DPPH Method (1,1-diphenyl-2-picrylhydrazyl) JF - Borneo Journal of Pharmacy JA - Borneo J Pharm VL - 5 IS - 4 SE - Pharmacognosy-Phytochemistry DO - 10.33084/bjop.v5i4.3511 UR - https://journal.umpr.ac.id/index.php/bjop/article/view/3511 SP - 315-324 AB - <p style="text-align: justify;">Free radicals in the human body can be helped neutralized by natural antioxidants derived from plants. Pepaya Jepang (<em>Cnidoscolus aconitifolius</em> (Mill.) I.M.Johnst) contains antioxidant compounds such as flavonoids and polyphenols. This study examined the antioxidant activity of 96% ethanol extract of <em>C. aconitifolius</em> leaves. Maceration of <em>C. aconitifolius</em> leaves using 96% ethanol solvent, phytochemical screening, and antioxidant activity assay was carried out with 1,1-Diphenyl-2-Picryl Hydrazil (DPPH) on 96% ethanol extract of <em>C. aconitifolius</em>. Extraction obtained a yield of 16.1834%, and phytochemical screening on the 96% ethanol extract of <em>C. aconitifolius </em>contained flavonoids, tannins, saponins, phenols, alkaloids, and steroids. The antioxidant activity assay on 96% ethanol extract of <em>C. aconitifolius</em> had an IC<sub>50</sub> value of 145.3855 ppm and an IC<sub>50</sub> value of vitamin C of 7.0806 ppm. The Antioxidant Activity Index (AAI) of 96% ethanol extract of <em>C. aconitifolius </em>was 0.4127, and the AAI of vitamin C was 8.4739. Based on the results obtained, although in a weak classification, a 96% ethanol extract of <em>C. aconitifolius</em> leaves has antioxidant activity.</p> ER -