Kombinasi Rebusan Daun Salam dan Kemangi dalam Menurunkan Kadar Asam Urat Mus musculus

Combination Of Bay And Basil Leaves To Decrease The Mus Musculus Uric Acid Levels

Authors

  • Fahlia Nirmala Universitas Maarif Hasyim Latif
  • Kholifatuz Zumaroh Universitas Maarif Hasyim Latif
  • Novia Afriani Donatomo Universitas Maarif Hasyim Latif
  • Khoirul Ngibad Universitas Maarif Hasyim Latif https://orcid.org/0000-0003-1471-7347

DOI:

https://doi.org/10.33084/bjmlt.v2i1.1088

Keywords:

bay leaves (Syzygium polyanthum), basil leaves (Ocimum basilicum), uric acid, herbs

Abstract

Indonesia is one of the world’s largest of biodiversity. Especially bay leaves (Syzygium polyanthum) and basil leaves (Ocimum basilicum). These plants can be used to reduce blood uric acid. This study aimed to determine the optimum dose that could reduce uric acid levels by providing a combination of decoction of basil leaves and bay leaves and to knew the phytochemical compounds that could reduce uric acid levels in basil leaves and bay leaves. The antihiperuricemia activity of boiled bay leaves and basil leaves was tested on male sex mice (Mus musculus) Balb / C strain, aged 8-10 weeks to reveal the effectiveness of bay leaves and basil leaves as blood uric acid-lowering. The dosage of decoction used is 1.5 glasses, 1 glass, and 0.5 glass from the shrinking of the cooking water which was originally 2 glasses. Tests were carried out on mice that experienced hyperuricemia induced by potassium oxonate 250 mg / kg BW or 5 mg / 20 g BB in mice intraperitoneally and mixed chicken liver, sprouts and melinjo. Measuring the level of urate is done using the POCT (Point Of Care Tasting) method. The results showed that combination of boiled bay leaves and basil leaves could reduce blood uric acid levels in mice around 0.5 - 1.0 mg / dl. The activity was effective in both doses, 0.5 glass and 1.5 glasses, but to get a significant decrease in uric acid levels this cooking water had to be consumed regularly and for a longer time.

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References

Andriani, A., & Chaidir, R. 2016. Pengaruh Pemberian Air Rebusan Daun Salam (Syzygium Polyanthum) Terhadap Penurunan Kadar Asam Urat. Jurnal Ipteks Terapan. 10(2):112-119.
Darussalam, M., & Rukmi, D. K. 2016. Peran Air Rebusan Daun Salam (Syzgium polyanthum) Dalam Menurunkan Kadar Asam Urat. Media Ilmu Kesehatan, 5(2):83-91.
Efendi, S. 2017. “Ir- perpustakaan universitas airlangga”.
Ismanto, A. Y., & Masi, G. 2016. Pengaruh Air Rebusan Daun Kemangi Terhadap Kadar Asam Urat Darah Pada Penderita Hiperurisemia Di Wilayah Kerja Puskesmas Wolaang. JURNAL KEPERAWATAN. 4(1).
Kusumayanti, G. A. D., Wiardani, N. K., & Sugiani, P. P. S. 2014. Diet Mencegah dan Mengatasi Gangguan Asam Urat. Jurnal Ilmu Gizi. 5 (1):69-78.
Lehninger, A. L. 1982. Dasar-dasar biokimia Jilid 1. Jakarta: Erlangga.
Ngibad, K. 2019. Efektivitas Kombinasi Ekstrak Etanol Daun Bunga Matahari dan Tanaman Anting-Anting sebagai Antimalaria Secara In Vivo. Galen Medical Journal. 5(1):12-19.
Ngibad, K. 2019. Phytochemical Screening of Sunflower Leaf (Helianthus annuus) and Anting-Anting (Acalypha indica Linn) Plant Ethanol Extract. Borneo Journal of Pharmacy. 2(1):24-30.
Ningtiyas, I. F., & Ramadhian, M. R. 2016. Efektivitas Ekstrak Daun Salam untuk Menurunkan Kadar Asam Urat pada Penderita Artritis Gout. Journal Major. 5(3):105-110.
Saifudin, A. 2014. Senyawa Alam Metabolit Sekunder Teori, Konsep, dan Teknik Pemurnian. Yogyakarta: Penerbit Deepublish.
Suhendi, A., Wahyuningtyas, N., & Sutrisna, E. M. Uji Praklinik Antihiperurisemia Secara In Vivo Pada Mencit Putih Jantan Galur Balb-C dari Ekstrak Daun Salam (Syzigium polyanthum Walp) dan Daun Belimbing Wuluh (Averrhoa bilimbi L.). Biomedika.6(1).
Utami, P., & Lentera, T. 2003. Tanaman Obat untuk Mengatasi Diabetes Mellitus. Jakarta Selatan: AgroMedia.

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Published

2019-10-31

How to Cite

Nirmala, F., Zumaroh, K., Donatomo, N. A., & Ngibad, K. (2019). Kombinasi Rebusan Daun Salam dan Kemangi dalam Menurunkan Kadar Asam Urat Mus musculus: Combination Of Bay And Basil Leaves To Decrease The Mus Musculus Uric Acid Levels. Borneo Journal of Medical Laboratory Technology, 2(1), 109–115. https://doi.org/10.33084/bjmlt.v2i1.1088