APTT (Activated Partial Thromboplastin Time) dan (Prothrombin Time) pada Penderita Diabetes Melitus Tipe 2 di RSUD dr. Doris Sylvanus Palangkaraya
APTT (Activated Partial Thromboplastin Time) and PT (Prothrombin Time) in Diabetes Mellitus Type 2 in RSUD dr. Doris Sylvanus Palangkaraya
DOI:
https://doi.org/10.33084/bjmlt.v2i2.1384Keywords:
APTT, PT, type 2 diabetes mellitusAbstract
Patients with type 2 diabetes mellitus (T2DM) have a high risk of atherothrombotic events. Hyperglycemia and other metabolic disorders in T2DM are associated with abnormalities of hemostasis system and thrombosis that contribute to cardiovascular disease. Routine laboratory tests to examine the hemostasis system are Activated Partial Thromboplastin Time (APTT) and Prothrombin Time (PT). This study aimed to describe the abnormalities of APTT and PT in patients with T2DM in RSUD dr. Doris Sylvanus Palangkaraya. Twenty subjects with T2DM in RSUD dr. Doris Sylvanus Palangkaraya were obtained using purposive sampling techniques and blood samples were examined with a COATX Biosystem coagulation using photocolorimetric method. This study found that was 70% APTT are shortened, 5% APTT are prolonged and 25% APTT were normal. While the PT results were 25% PT are shortened and 75% APTT were normal. Abnormalities of APTT and PT in T2DM patients in RSUD dr. Doris Sylvanus Palangkaraya showed an abnormality of the coagulation system so as to allow a tendency for bleeding and cardiovascular disease in T2DM patients. Routine coagulation test should be continued to help better diabetes mellitus management in order to prevent micro or macrovascular complications.
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Awad, A., Hassan, A. and Babiker, L. 2016.‘Assessment of some coagulation parameters ( PT , APTT , INR , PLTS COUNT and PLT indices ) in Sudanese Patients with Diabetic Type 2 January 2016’, 4(2), pp. 1570–1585.
Bashir, B. A. and Ali, M. S. 2018. ‘Hemostatic state augmented with platelet indices among Sudanese diabetic septic foot’, BMC Hematology. BMC Hematology, 18(1), pp. 5–10.
Elhassade, A. S., and Balha, O. S. 2016. ‘Effect of Diabetes Mellitus Type II on Activated Partial Thromboplastin Time and Prothrombin Time’, International Journal of Clinical and Biomedical Research, 2(3), pp. 1–4.
Ephraim, R. K., Awuku, YA., Adu, P., Ampomah, LT., Adoba, P., Panford, S., Ninnoni, JP., Agbodzakey, H. 2017.‘High risk of coagulopathy among Type-2 Diabetes Mellitus clients at a municipal hospital in Ghana’, Ghana medical journal, 51(3), pp. 101–107.
Karim, F., Akter, QS., Jahan, S., Khanom, S., Haque, S., Yeasmin, T., Siddika, T., Sinha, S. 2015. ‘Coagulation Impairment in Type 2 Diabetes Mellitus’, Journal of Bangladesh Society of Physiologist, 10(1), pp. 26–29.
Lippi, G., Salvagno, GL., Ippolito, L., Franchini, M., Favaloro, EJ. 2010. ‘Shortened activated partial thromboplastin time: Causes and management’, Blood Coagulation and Fibrinolysis, 21(5), pp. 459–463.
McFarlane, S. I. 2017. ‘Shift work and sleep: medical implications and management’, Sleep Medicine and Disorders: International Journal, 1(2), pp. 1–14. doi: 10.15406/smdij.2017.01.00008.
Omer Ibrahim Abdallah Mohammed. 2020. ‘Estimation of prothrombin time, activated partial thromboplastin time and thrombocytes among Sudanese patients with diabetes’, GSC Biological and Pharmaceutical Sciences, 10(1), pp. 034–038.
Thukral, S., Hussain, S., Bhat, S., Kaur, N., Reddy, A. 2018 ‘Prothrombin Time (PT) and Activated Partial Thromboplastin Time (APTT) in Type 2 Diabetes Mellitus, a Case Control Study’, International Journal of Contemporary Medical Research, 5(8), pp. H5–H9.
Zhao, Y., Zhang, J., Zhang, J., Wu, J. 2011. ‘Diabetes mellitus is associated with shortened activated partial thromboplastin time and increased fibrinogen values’, PLoS ONE, 6(1), pp. 4–7.
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