Effect of Red Cabbage Juice as a Hepatoprotector on Liver Enzyme Levels
Efek Jus Kubis Merah sebagai Hepatoprotektor pada Kadar Enzim Hati
DOI:
https://doi.org/10.33084/bjmlt.v4i1.2957Keywords:
red cabbage, acetaminophen, SGOT, ALP, GGTAbstract
Background: Anthocyanin-rich red cabbage is known to reduce hepatic enzymes levels such as SGPT, SGOT, ALP, and GGT in drug-induced liver injury (DILI). Objective: This study aimed to determine the effect of red cabbage juice on SGOT, ALP, and GGT levels in acetaminophen-induced liver injury in rats.
Methods: This was an experimental study using a post-test-only control group design. Thirty male Wistar rats were randomly divided into 5 groups. K1 was the negative control. K2, K3, K4, and K5 were pretreated with 300 mg acetaminophen. K3, K4, and K5 were treated with 0.5 g/ml of red cabbage juice, 0.7 g/ml of red cabbage juice, and 0.9 g/ml of red cabbage juice respectively. Data were analyzed using one-way ANOVA and post hoc LSD (p<0.05).
Results: There was no significant difference in SGOT and GGT levels among the groups p=0.271(p>0.05) and p=0.053 (p>0.05) respectively. Whereas ALP levels showed significant differences among the groups p=0.000 (p<0,05) respectively.
Conclusion: The administration of red cabbage in any dose had no effect on SGOT and GGT levels in acetaminophen-induced liver injury in rats whereas in ALP, the most effective dose to cause an effect is 0.5 g/ml.
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Li, D., Wang, P., Luo, Y., Zhao, M., Chen, F. 2017. 'Health Benefits of Anthocyanins and Molecular Mechanisms : Update From Recent Decade', Critical Reviews in Food Science and Nutrition, Taylor & Francis, 57(8), pp. 1729–1741.
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Mazaleuskaya, L.L., Sangkuhl, K., Thorn, F.C., FitzGearld, G.A., Altman, R.B., Klein, E.T. 2015. 'PharmGKB Summary : Pathways of Acetaminophen Metabolism at The Therapeuticversus Toxic Doses', Pharmacogenet Genomics, 25(8), pp. 416–426.
Nair, B., Singh, K.P., Chand, P. 2014. Fundamental of Vegetable Crop Production. Jodhpur : Scientific Publisher.
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Poupon, R. 2015. 'Liver alkaline phosphatase : a Missing Link Between Choleresis and Biliary Inflammation', Hepatology, 61(6), pp. 2080–2090.
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Rokayya, S., Li, Chun-juan., Zhao, Yan., Li, Ying., Sun, Chang-hao. 2013 'Cabbage (Brassica oleracea L . var . capitata) Phytochemicals with Antioxidant and Anti-inflammatory Potential', Asian Pasific Journal of Cancer Prevention, 14(11), pp. 6657–6662.
Saraç, F. dan Saygılı, F. 2007. 'Causes of High Bone Alkaline Phosphatase', Biotechnology & Biotechnological Equipment, Taylor & Francis, 21(2), pp. 194–197.
Sayuti, K., Yenrina, R. 2015. Antioksidan Alami dan Sintetik. Cetakan Pertama. Padang : Andalas University Press.
Schmidt, J., Grober U., Kisters, K. 2015. 'Magnesium in Prevention and Therapy', Nutrients, 7(9), pp. 8199–8226.
Selby, A. 2010. Makanan Berkhasiat. Jakarta : Erlangga.
Sepulveda, J. 2013. 'Challenges in Routine Clinical Chemistry Analysis : Protein and Enzimes', New York, Elsevier
Sharma, C. V. and Mehta, V. 2014. ‘Paracetamol: Mechanisms and Updates’, Continuing Education in Anaesthesia, Critical Care and Pain, 14(4), pp. 153–158.
Sharma, U., Pal, D. dan Prasad, R. 2014. 'Alkaline phosphatase : an Overview', Indian Journal of Clinical Biochemistry, 29(3), pp. 269–278.
Smith, G. S., Wolter, G. L., Wolker, R. M. 2013. 'Clinical Pathology in Nonclinical Toxicology Testing', United States, Elsevier.
Tariq, A., Bilal, M., Khan, S., Quratulain, Shahid, M. F., Khan, M. W., Shah, A. R., Naveed, A. K. 2011. 'Influence of Gender, BMI, and Ethnicity on Serum ALT Levels of Healthy Students of a Medical School', Journal of Ayub Medical College, Abbottabad : JAMC, 23(1), pp. 70–72.
Vroon, D. H. dan Israili, Z. 1990. 'Alkaline Phosphatase and Gamma Glutamyltransferase, Clinical Methods: The History, Physical, and Laboratory Examinations', pp. 494–496.
Wahyuningsih, H. and Aulia, A. P. 2020. ‘Review: Effect of Red Cabbage Juice (Brassica oleracea var. Capitata f. Rubra) on SGPT Level’, Borneo Journal of Medical Laboratory Technology, 3(1), pp. 172–177. doi: 10.33084/bjmlt.v3i1.1791.
Wang, L., Zhao, Y., Zhuo, Q., Luo, C.L., Deng, A.P., Zhang, Z.C., Zhang, J.L. 2017. 'Characterization and Hepatoprotective Activity of Anthocyanins from Purple Sweet Potato (Ipomoea batatas L. cultivar Eshu No. 8)', Journal of Food and Drug Analysis, Elsevier Ltd, 25(3), pp. 607–618.
Yoon, E., Babar, A., Choudhary, M., Kutner, M., Pyrsopoulus, N. 2016. 'Acetaminophen-Induced Hepatotoxicity: a Comprehensive Update', Journal of Clinical and Translational Hepatology, 4(2), pp. 131–142.
Yulia, A. dan Wijesiriwardana, A. 2017. 'Extremely High Isolated Maternal Alkaline Phosphatase Serum Concentration -2 Case Reports’, 2(4), pp. 111–113.
Zhang, J., Wang, Z., Liu, X. 2017. ‘Characterization Of Acylated Anthocyanins In Red Cabbage Via Comprehensive Two-Dimensional High Performance Liquid Chromatography and HPLC-MS’, Journal of Food Processing and Preservation, 41(2), pp. 1–7
Aulbach, A. D., Amuzie, C. J. 2017. 'Biomarkers in Nonclinical Drug Development', Elsevier.
Cahaya, N., dan Mutia, R. 2014. 'Evaluasi Obat-Obatan Berpotensi Hepatotoksik pada Pasien Dengan Gangguan Fungsi Hati di Ruang Rawat Inap RSUD Ulin Banjarmasin', Jurnal Pharmascience, 1(2), pp. 16–26.
Chambial, S. dan Dwivedi, S. 2013. 'Vitamin C in Disease Prevention and Cure : An Overview', Indian J. Clin. Biochem., 28(4), pp. 314–328.
Chughlay, M., Kramer, N., Werfalli, M., Spearman, W., Engel, M., Cohen, K. 2015. 'N -acetylcysteine for Non-Paracetamol Drug-Induced Liver Injury : a Systematic Review Protocol', Systematic Reviews,pp. 1–6.
Dalimartha, S. 2008. Atlas Tanaman Obat Indonesia. Cetakan Keempat. Jakarta : Niaga Swadaya.
Damayanti, D. 2008. Buku Pintar Tanaman Obat. Cetakan Pertama. Jakarta : Agromedia Pustaka.
Devi, C.B., Basar, G., Devi, N.O., Jamir, S., Nandakishore, T., Singh M.A. . 2014. 'Zinc in Human health', IOSR Journal of Dental and Medical Science, 13 (7), pp. 18–23.
Draghici, G.A., Alexandra, L.A., Aurica-Breica, B., Nica D., Alda S., Liana, S., Gogoasa I., Gergen I., Despina-Maria, B. (2013) 'Red Cabbage Millennium's Functional Food', Journal of Horticulture, Forestry and Biothecnology, 17 (4), pp. 52–55.
Dzoyem, J. P., Kuete, V., Eloff, J. N. 2014. 'Biochemical Parameters in Toxicological Studies in Africa, Principles of Method, Data Interpretation and Use in Plant Screening', Elsevier.
El-Motaleb el-Mowafy, M.A. 2012. 'Treatment Effect of Red Cabbage and Cysteine Against Paracetamol Induced', Journal of Applied Science Research, 8(12), pp. 5852–5859.
Horbowicz, M., Kosson, R., Grzesiuk, A. 2008. 'Anthocyanins of Fruits and Vegetables - Their Occurrence', Analysis, pp. 5–22.
Huang, X., Choi, Y., Im, H., Yarimaga, O., Yoon, E., Kim, H. (2006) 'Aspartate Aminotransferase (AST/GOT) and Alanine Aminotransferase (ALT/GPT) Detection Techniques', Sensors, 6(7), pp. 756–782.
Indrawaty, S., Sosialine, E., Umar, F., Pahlemy, Helsy. 2011 Pedoman Interpretasi Data Klinik. Jakarta : Kementerian Kesehatan Republik Indonesia.
Jakobek, L. Seruga, M., Medvidovic-Kosanovic, M., Novak, I. 2007 'Anthocyanin Content and Antioxidant Activity of Various Red Fruit Juices', Deutsche Lebensmittel-Rundschau : Zeitschrift fur Lebensmittelkunde und Lebensmittelrecht, 103(2), pp. 58–64.
Jaeschke, H. 2016. 'Acetaminophen Dose Dependent Drug Hepatotoxicity and Acute Liver Failure', Dig. Dis., 33(4), pp. 464–471.
Jang, E. S. et al. 2012. ‘Effects of Coffee, Smoking, and Alcohol on liver Function Tests: a Comprehensive Cross-Sectional Study’, BMC Gastroenterology. BMC Gastroenterology, 12(1), pp. 145.
Kabir, A., Pourshams, A., Khoshnia, M., Malekzadeh, F. 2013. 'Normal Limit for Serum Alanine Aminotransferase Level and Distribution of Metabolic Factors in Old Population of Kalaleh', Iran, Hepatitis Monthly, 13(10).
Kingston, J. K. 2008. 'Hematologic and Serum Biochemical Responses to Exercise and Training', Elsevier.
Koenig, G. dan Seneff, S. 2015. 'Gamma-Glutamyltransferase : A Predictive Biomarker of Cellular Antioxidant Inadequacy and Disease Risk', Disease Markers.
Kozłowska, A. dan Szostak-węgierek, D. 2014. 'Flavonoids - Food Sources and Health Benefits', Rocz. Panstw. Zakl. Hig., 65(2), pp. 79–85.
Legato, M. J. 2004. 'Principles of Gender-Specific Medicine', Elsevier.
Li, D., Wang, P., Luo, Y., Zhao, M., Chen, F. 2017. 'Health Benefits of Anthocyanins and Molecular Mechanisms : Update From Recent Decade', Critical Reviews in Food Science and Nutrition, Taylor & Francis, 57(8), pp. 1729–1741.
Lingga, L. 2010. Cerdas Memilih Sayuran. Cetakan Pertama. Jakarta : Agromedia Pustaka.
Mazaleuskaya, L.L., Sangkuhl, K., Thorn, F.C., FitzGearld, G.A., Altman, R.B., Klein, E.T. 2015. 'PharmGKB Summary : Pathways of Acetaminophen Metabolism at The Therapeuticversus Toxic Doses', Pharmacogenet Genomics, 25(8), pp. 416–426.
Nair, B., Singh, K.P., Chand, P. 2014. Fundamental of Vegetable Crop Production. Jodhpur : Scientific Publisher.
Pandey, K. B. dan Rizvi, S. I. 2009. 'Plant Polyphenols as Dietary Antioxidants in Human Health and Disease', Oxid. Med. Cell Longev., 2(5), pp. 270–278.
Poupon, R. 2015. 'Liver alkaline phosphatase : a Missing Link Between Choleresis and Biliary Inflammation', Hepatology, 61(6), pp. 2080–2090.
Pour Amin Reza, J. 2016. 'Effects of Acetaminophen as a Toxic Drug on the Liver Function in Poultry', Journal of Cancer Prevention & Current Research, 4(4).
Rokayya, S., Li, Chun-juan., Zhao, Yan., Li, Ying., Sun, Chang-hao. 2013 'Cabbage (Brassica oleracea L . var . capitata) Phytochemicals with Antioxidant and Anti-inflammatory Potential', Asian Pasific Journal of Cancer Prevention, 14(11), pp. 6657–6662.
Saraç, F. dan Saygılı, F. 2007. 'Causes of High Bone Alkaline Phosphatase', Biotechnology & Biotechnological Equipment, Taylor & Francis, 21(2), pp. 194–197.
Sayuti, K., Yenrina, R. 2015. Antioksidan Alami dan Sintetik. Cetakan Pertama. Padang : Andalas University Press.
Schmidt, J., Grober U., Kisters, K. 2015. 'Magnesium in Prevention and Therapy', Nutrients, 7(9), pp. 8199–8226.
Selby, A. 2010. Makanan Berkhasiat. Jakarta : Erlangga.
Sepulveda, J. 2013. 'Challenges in Routine Clinical Chemistry Analysis : Protein and Enzimes', New York, Elsevier
Sharma, C. V. and Mehta, V. 2014. ‘Paracetamol: Mechanisms and Updates’, Continuing Education in Anaesthesia, Critical Care and Pain, 14(4), pp. 153–158.
Sharma, U., Pal, D. dan Prasad, R. 2014. 'Alkaline phosphatase : an Overview', Indian Journal of Clinical Biochemistry, 29(3), pp. 269–278.
Smith, G. S., Wolter, G. L., Wolker, R. M. 2013. 'Clinical Pathology in Nonclinical Toxicology Testing', United States, Elsevier.
Tariq, A., Bilal, M., Khan, S., Quratulain, Shahid, M. F., Khan, M. W., Shah, A. R., Naveed, A. K. 2011. 'Influence of Gender, BMI, and Ethnicity on Serum ALT Levels of Healthy Students of a Medical School', Journal of Ayub Medical College, Abbottabad : JAMC, 23(1), pp. 70–72.
Vroon, D. H. dan Israili, Z. 1990. 'Alkaline Phosphatase and Gamma Glutamyltransferase, Clinical Methods: The History, Physical, and Laboratory Examinations', pp. 494–496.
Wahyuningsih, H. and Aulia, A. P. 2020. ‘Review: Effect of Red Cabbage Juice (Brassica oleracea var. Capitata f. Rubra) on SGPT Level’, Borneo Journal of Medical Laboratory Technology, 3(1), pp. 172–177. doi: 10.33084/bjmlt.v3i1.1791.
Wang, L., Zhao, Y., Zhuo, Q., Luo, C.L., Deng, A.P., Zhang, Z.C., Zhang, J.L. 2017. 'Characterization and Hepatoprotective Activity of Anthocyanins from Purple Sweet Potato (Ipomoea batatas L. cultivar Eshu No. 8)', Journal of Food and Drug Analysis, Elsevier Ltd, 25(3), pp. 607–618.
Yoon, E., Babar, A., Choudhary, M., Kutner, M., Pyrsopoulus, N. 2016. 'Acetaminophen-Induced Hepatotoxicity: a Comprehensive Update', Journal of Clinical and Translational Hepatology, 4(2), pp. 131–142.
Yulia, A. dan Wijesiriwardana, A. 2017. 'Extremely High Isolated Maternal Alkaline Phosphatase Serum Concentration -2 Case Reports’, 2(4), pp. 111–113.
Zhang, J., Wang, Z., Liu, X. 2017. ‘Characterization Of Acylated Anthocyanins In Red Cabbage Via Comprehensive Two-Dimensional High Performance Liquid Chromatography and HPLC-MS’, Journal of Food Processing and Preservation, 41(2), pp. 1–7
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Published
2021-10-31
How to Cite
Aulia, A. P., & Wahyuningsih, H. (2021). Effect of Red Cabbage Juice as a Hepatoprotector on Liver Enzyme Levels: Efek Jus Kubis Merah sebagai Hepatoprotektor pada Kadar Enzim Hati. Borneo Journal of Medical Laboratory Technology, 4(1), 272–278. https://doi.org/10.33084/bjmlt.v4i1.2957
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