Hubungan Antara Kadar Magnesium Serum Dengan HbA1c Pada Penderita Diabetes Mellitus Tipe 2 Di RSUP Fatmawati Jakarta: Correlation between MagnesiumSerum and HbA1c Levels in Patients with Type 2 Diabetes Mellitus at Fatmawati General Hospital Jakarta

Tri Prasetyorini; Diah Lestari; Wandira Nur Eka Putri

doi:10.33084/bjmlt.v6i1.6089

Authors

Tri Prasetyorini Poltekkes Kemenkes Jakarta III
Diah Lestari Poltekkes Kemenkes Jakarta III
Wandira Nur Eka Putri Poltekkes Kemenkes Jakarta III

DOI:

https://doi.org/10.33084/bjmlt.v6i1.6089

Keywords:

Diabetes Mellitus, Tipe 2, Magnesium, Serum, HbA1c

Abstract

Diabetes Mellitus (DM) is a collection of symptoms that arise in a person caused by an increase in blood glucose levels due to a progressive decrease in insulin secretion. magnesium (Mg) plays an important role in insulin secretion, insulin binding, and homeostasis. Mg Serum level is an important factor in the etiology and development of macrovascular and microvascular complications in diabetes mellitus patients. HbA1c in DM patients is used to monitor glycemic control and predict the progression of diabetes complications. The purpose of this study was to determine the relationship between serum magnesium and HbA1c levels in patients with type 2 diabetes mellitus. The design of this study was an analytical observational study with a cross-sectional design. The data used are secondary data obtained from patients with type 2 diabetes mellitus at Fatmawati General Hospital for the period 2019 – 2020. The research sample used was 84 data for patients with type 2 diabetes mellitus. Analysis of the data used includes descriptive analysis and then hypothesis testing using the Spearman correlation test. The result of this study showed an association between serum magnesium and HbA1c levels with a value of p = 0,000 (p ≤ 0,05) and r = 0,513. The conclusion obtained in this study is that there is a strong negative pattern relationship between serum magnesium and HbA1c levels in type 2 diabetes mellitus.

Downloads

Download data is not yet available.

References

American Diabetes Association (2018) ‘Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2018’, Diabetes Care, 41(January), pp. S13–S27. doi: 10.2337/dc18-S002.

Charisma, A. M. (2017) ‘Korelasi Kadar Rata-Rata Glukosa Darah Puasa Dan 2 Jam Post Prandial Tiga Bulan Terakhir Dengan Nilai Hba1c Pada Pasien Diabetes Melitus Prolanis Bpjs Kabupaten Kediri Periode Mei-Agustus 2017’, Jurnal Kesehatan Masyarakat, 12(2), pp. 1–11.

Edi Tarigan, T. J., Marbun, M. B. H. and Harimurti, K. (2015) ‘Korelasi Kadar Magnesium Serum dengan Albuminuria pada Pasien Diabetes Melitus Tipe 2’, eJournal Kedokteran Indonesia, 3(2), pp. 115–119. doi: 10.23886/ejki.3.5044.

El-said, N. H., Sadik, N. A. and Mohammed, N. A. E. (2015) ‘Magnesium in Type 2 Diabetes Mellitus and its Correlation With Glycemic Control’, International Journal of Research in Medical Sciences, (June). doi: 10.18203/2320-6012.ijrms20150308.

Elderawi, W. A. et al. (2018) ‘The Effects of Oral Magnesium Supplementation on Glycemic Response among Type 2 Diabetes Patients’, Nutrients, 11(1), pp. 12–14. doi: 10.3390/nu11010044.

Gupta, S., Jain, U. and Chauhan, N. (2017) ‘Laboratory Diagnosis of HbA1c: A Review’, Journal of Nanomedicine Research, 5(4), pp. 1–10. doi: 10.15406/jnmr.2017.05.00120.

International Diabetes Federation (2017) ‘IDF Diabetes Atlas 8th Edition’, (January).

Jahnen-Dechent, W. and Ketteler, M. (2012) ‘Magnesium basics’, CKJ: Clinical Kidney Journal, 5(SUPPL. 1). doi: 10.1093/ndtplus/sfr163.

KEMENKES RI (2012) ‘Penyakit Tidak Menular’, Buletin Jendela Data dan Informasi Kesehatan, 2, pp. 1–14.

KEMENKES RI (2019) ‘Hari Diabetes Sedunia Tahun 2018’, Pusat Data dan Informasi Kementrian Kesehatan RI, pp. 1–8.

Kostov, K. (2019) ‘Effects of Magnesium Deficiency on Mechanisms of Insulin Resistance in Type 2 Diabetes: Focusing on the Processes of Insulin Secretion and Signaling’, International Journal of Molecular Sciences, 20(6). doi: 10.3390/ijms20061351.

Noor, M. M. et al. (2019) ‘Association Between Low Serum Magnesium Level And Type 2 Diabetes Mellitus In Abbottabad’, Journal of Ayub Medical College, Abbottabad : JAMC, 31(2), pp. 226–229.

Parlapally, R. P., Kumari, K. R. and Jyothi, S. A. (2016) ‘Serum Magnesium Levels in Type 2 Diabetes with Metabolic Syndrome’, National Journal of Physiology, Pharmacy and Pharmacology, 6(6), pp. 520–525. doi: 10.5455/njppp.2016.6.0615307062016.

PERKENI (2015) ‘Konsensus Pengelolaan dan Pencegahan Diabetes Melitus Tipe 2 di Indonesia’, Jakarta: PB PERKENI.

Pokharel, D. R. et al. (2017) ‘Association of Serum Magnesium Level with Poor Glycemic Control and Renal Functions in Nepalese Patients with Type 2 Diabetes Mellitus’, Diabetes and Metabolic Syndrome: Clinical Research and Reviews. Diabetes India, 11, pp. S417–S423. doi: 10.1016/j.dsx.2017.03.028.

Prasetyorini, T., Cindy and Salbiah (2021) ‘Correlation of HbA1c levels with Triglyceride , LDL and HDL levels in Type 2 Diabetes Mellitus Patients’, International Journal of Science and Society, 3(2), pp. 138–145. doi: https://doi.org/10.200609/ijsoc.v3i2.325.

RISKESDAS (2018) ‘Laporan Nasional RISKESDAS 2018’, Jakarta: Kemenkes RI.

Saproo, N. and Singh, R. (2017) ‘Study of Serum Magnesium Levels in Diabetes Mellitus and its Correlation with Complications (Retinopathy and HbA1c) a cross-sectional Study of One Year’, International Journal of Advances in Medicine, 4(1), p. 263. doi: 10.18203/2349-3933.ijam20170123.

Sari, M. A. (2016) Faktor Risiko Kejadian Diabetes Melitus tipe 2 pada Masyarakat Urban Kota Semarang (Studi Kasus di RSUD Tugurejo Semarang), Public Health Science Department. Universitas Negeri Semarang.

Setiawati, D., Nuhriawangsa, A. and Wasita, B. (2019) ‘Hubungan Magnesium Serum Dengan Kadar Glukosa Darah Pada Dewasa Overweight Dan Obesitas’, Amerta Nutrition, 3(4), pp. 239–246. doi: 10.20473/amnt.v3i4.2019.239-246.

Trisnawati, S. K. and Setyorogo, S. (2013) ‘Faktor Risiko Kejadian Diabetes Melitus Tipe II di Puskesmas Kecamatan Cengkareng Jakarta Barat Tahun 2012’, Jurnal Ilmiah Kesehatan, 5(1), pp. 6–11.

Umer Siddiqui, M. et al. (2016) ‘Frequency Of Hypomagnesemia In Patients With Uncontrolled Type II Diabetes Mellitus’, Pak Armed Forces Med J, 66(6), pp. 845–50. Available at: https://pafmj.org/index.php/PAFMJ/article/view/1025.

World Health Organization (2014) Global Status Report On Noncommunicable Diseases 2014.

World Health Organization (2016) Global Report On Diabetes. Geneva PP - Geneva: World Health Organization. Available at: https://apps.who.int/iris/handle/10665/204871.

Yanti, S. (2019) Faktor-Faktor Yang Berhubungan Dengan Kepatuhan Penderita Diabetes Mellitus Dalam Pengontrolan Kadar HbA1c Di Laboratorium Klinik Prodia Banda Aceh Tahun 2019, Universitas Muhammadiyah Aceh. Muhammadiyah Aceh.

Yosmar, R., Almasdy, D. and Rahma, F. (2018) ‘Survei Risiko Penyakit Diabetes Melitus Terhadap Masyarakat Kota Padang’, Jurnal Sains Farmasi Dan Klinis, 5(Agustus 2018), pp. 134–141.