Analisis Efektivitas Biaya Terapi Kombinasi Mood Stabilizer dan Antipsikotik pada Pasien Gangguan Afektif Bipolar di Rawat Inap RSJ Grhasia Yogyakarta

Cost Effectiveness Analysis of Combination Mood Stabilizer and Antipsychotic Therapy In Bipolar Affective Disorder Patients at Grhasia Mental Hospital Yogyakarta

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DOI:

https://doi.org/10.33084/jsm.v6i2.1967

Keywords:

cost effectiveness analysis, bipolar affective disorder, mood stabilizer, antipsychotic, length of stay

Abstract

Bipolar affective disorder is an episodic mental disorder characterized by manic, hypomanic, depressive, and mixed episodes, usually recurring and can last a lifetime. Patients with bipolar disorder have annual medical costs that were four times those of patients without bipolar disorder. The aim of this study is to analyze the cost-effectiveness of combination therapy between mood stabilizers and antipsychotics in patients with the bipolar affective disorder at Grhasia Mental Hospital Yogyakarta. This study is a retrospective with cohort study design using medical records and direct medical cost data during Januari-December 2018 period. Subjects are patients who were diagnosed with bipolar affective disorder manic episode (F31.2) and received a combination of mood stabilizer and antipsychotic therapy. The results were obtained in 46 patients with the affective disorder who met the inclusion criteria. The average direct medical cost of the sodium divalproate group was IDR 6.319.933 per day and in the lithium group was IDR 5.705.953 per day. The average length of stay in the sodium divalproate group was 25,79 days and in the lithium group was 25,75 days (P = 0,991). The Average Cost Effectivity Ratio (ACER) sodium divalproat group is lower than the lithium group (IDR 221.246 per day and IDR 245.434 per day, respectively). The conclusion of this study is that the combination of sodium divalproate-antipsychotic therapy is more cost-effective than lithium-antipsychotic therapy in a patient with bipolar affective disorder manic episode

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References

1. Ikawati, Zullies; Anurogo, D. (2018). Tata Laksana Terapi Penyakit Sistem Syaraf Pusat (Pertama). Yogyakarta: Bursa Ilmu.
2. Kementrian Kesehatan. (2015). PEDOMAN NASIONAL PELAYANAN KEDOKTERAN JIWA.
3. Dinas Kesehatan Republik Indonesia. (2018). Riset Kesehatan Dasar.
4. SIMRS Ghrasia Yogyakarta. (2018). Laporan Data 10 Besar Penyakit Rawat Inap RSJ Ghrasia Yogyakarta. Yogyakarta.
5. Falita. (2013). Pola Pengobatan Pada Pasien Gangguan Bipolar Di Rumah Sakit Grhasia Yogyakarta Pada Tahun 2009-2011. 1–32. Retrieved from http://etd.repository.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=64876
6. Putri, kurnia indriany. (2016). Evaluasi peresepan obat pasien gangguan bipolar di instalasi rawat inap rumah sakit jiwa grhasia tahun 2014 kurnia indriany putri.
7. Kemenkes RI. (2013). Buku Pedoman Farmakoekonomi. Jakarta: Kementrian Kesehatan Republik Indonesia.
8. Desu, P. K. (2018). Pharmacoeconomics: an overview. (January).
9. Rascati, K. L. (2014). Essentials of Pharmacoeconomics Second Edition. In Lippincott Williams & Wilkins, a Wolters Kluwer business. https://doi.org/10.1017/CBO9781107415324.004
10. Andayani, T. M. (2013). Farmakoekonomi Prinsip dan Metodologi (Pertama). Yogyakarta: Bursa Ilmu.
11. Keck, P. E., Nabulsi, A. A., Taylor, J. L., Henke, C. J., Chmiel, J. J., Stanton, S. P., & Bennett, J. A. (1996). A pharmacoeconomic model of divalproex vs. lithium in the acute and prophylactic treatment of bipolar I disorder. Journal of Clinical Psychiatry, 57(5), 213–222.
12. Stender, M., & Health, D. G. (2002). Health care utilization and costs among privately insured patients with bipolar I disorder. (7), 398–405.
13. Wardati, Y., & Indrawati, D. K. (2018). Cost-effectiveness analysis of aripiprazole-escitalopram with aripiprazole-agomelatine as bipolar treatment in a pharmacy in Bandung, Indonesia. Drug Invention Today, 10(Special Issue 5), 3776–3780.
14. Gumintang, Y. (2018). Hubungan Faktor Karakteristik Pasien dengan Kejadian Interaksi Obat Antidepresan pada Pasien Rawat Jalan di Rumah sakit Jiwa Grhasia Yogyakarta. Digilib UAD. Retrieved from http://digilib.uad.ac.id/penelitian/Penelitian/detail/103714/hubungan-faktor-karateristik-pasien-dengan-kejadian-interaksi-obat-antidepresan-pada-pasien-rawat-jalan-bipolar-di-rumah-sakit-jiwa-grhasia-yogyakarta
15. NIMH. (2017). Prevalence of Bipolar Disorder Among Adults. National Institute of Mental Health. Retrieved from https://www.nimh.nih.gov/health/statistics/bipolar-disorder.shtml
16. Joslyn, C., Hawes, D. J., Hunt, C., & Mitchell, P. B. (2016). Is age of onset associated with severity, prognosis, and clinical features in bipolar disorder? A meta-analytic review. Bipolar Disorders, 18(5), 389–403. https://doi.org/10.1111/bdi.12419
17. Johan, ika meliana. (2017). Evaluasi Kerasionalan dan Kuantitas Penggunaan Kombinasi Obat Mood Stabilizer dan Antipsikotik Pada Pasien Bipolar di Rumah Sakit Jiwa Grhasia Yogyakarta. Digilib UAD. Retrieved from http://digilib.uad.ac.id/penelitian/Penelitian/detail/96124/evaluasi-kerasionalan-dan-kuantitas-penggunaan-kombinasi-obat-mood-stabilizer-dan-antipsikotik-pada-pasien-bipolar-di-rumah-sakit-jiwa-grhasia-yogyakarta
18. A. Kuruvilla & K.S. Jacob. (2007). Poverty, social stress & mental health. Department of Psychiatry, Christian Medical College, Vellore, India, (October), 273–278. Retrieved from https://www.researchgate.net/profile/Ks_Jacob/publication/5814418_Poverty_social_stress_mental_health/links/57cff94a08aed67897037669.pdf
19. Amir, N. (2010). Gangguan mood bipolar: kriteria diagnostik dan tatalaksana dengan obat antipsikotika atipik. Jakarta: Badan Penerbit FKUI.
20. Revicki, D. A., Hirschfeld, R. M. A., Ahearn, E. P., Weisler, R. H., Palmer, C., & Keck, P. E. (2005). Effectiveness and medical costs of divalproex versus lithium in the treatment of bipolar disorder: Results of a naturalistic clinical trial. Journal of Affective Disorders, 86(2–3), 183–193. https://doi.org/10.1016/j.jad.2005.01.002
21. Dalkilic, A., Diaz, E., Baker, C. B., Pearsall, H. R., & Woods, S. W. (2000). Effects of divalproex versus lithium on length of hospital stay among patients with bipolar disorder. Psychiatric Services, 51(9), 1184–1186. https://doi.org/10.1176/appi.ps.51.9.1184
22. Li, S. C., & Aggarwal, S. K. (2011). Estimation of resource utilisation difference between lithium and valproate treatment groups from the VALID study. Journal of Medical Economics, 14(3), 350–356. https://doi.org/10.3111/13696998.2011.581321

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Published

2021-02-15

How to Cite

Milasari, N., Perwitasari, D. A., & Sawitri, S. (2021). Analisis Efektivitas Biaya Terapi Kombinasi Mood Stabilizer dan Antipsikotik pada Pasien Gangguan Afektif Bipolar di Rawat Inap RSJ Grhasia Yogyakarta: Cost Effectiveness Analysis of Combination Mood Stabilizer and Antipsychotic Therapy In Bipolar Affective Disorder Patients at Grhasia Mental Hospital Yogyakarta. Jurnal Surya Medika (JSM), 6(2), 210–216. https://doi.org/10.33084/jsm.v6i2.1967

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Vol. 6 No. 2 (2021): Jurnal Surya Medika (JSM)

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