Skrining Senyawa dari Tanaman Rhodomyrtus tomentosa (Aiton) Hassk terhadap SARS-CoV-2 ORF3a

Screening af Compounds from Plant Rhodomyrtus tomentosa (Aiton) Hassk against SARS-CoV-2 ORF3a

Authors

  • Samsul Hadi Universitas Lambung Mangkurat

DOI:

https://doi.org/10.33084/jsm.v6i2.2134

Keywords:

ORF3a, Rhodomyrtus tomentosa, watsonianone A

Abstract

The ORF3a protein from SARS-CoV has functions in terms of ion channel activity, modulates the trafficking properties of SARS-CoV spike (S) protein, increases fibrinogen expression in pulmonary epithelial cells, and induces apoptosis. So that research is needed to overcome the ORF3a experiment. The method in this research uses the computational screening method with autodok4 software. The results of this study resulted in free binding energy between Hassk Rhodomyrtus tomentosa (Aiton) and ORF3a compounds, namely: α-tocopherol-quinone (-5.86); blumeatin (-4.98); methyl cinnamate (-4.44); myricetin (-4.49); naringenin (-4.93); quercetin (-4,9); rhodomyrtone (-6); rhodomyrtosone B (-7.11); rhodomyrtosone C (-6.77); tetrahydroxyflavanone (-4.91); α-tocopherol A (-6.72); verimol K (-4.89); watsonianone A (-7.55). Based on the data obtained, the ligand with the most potential due to the stability of the bond is watsonianone A.

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Published

2021-02-15

How to Cite

Hadi, S. (2021). Skrining Senyawa dari Tanaman Rhodomyrtus tomentosa (Aiton) Hassk terhadap SARS-CoV-2 ORF3a: Screening af Compounds from Plant Rhodomyrtus tomentosa (Aiton) Hassk against SARS-CoV-2 ORF3a. Jurnal Surya Medika (JSM), 6(2), 162–166. https://doi.org/10.33084/jsm.v6i2.2134

Issue

Vol. 6 No. 2 (2021): Jurnal Surya Medika (JSM)

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Articles

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