Obat Herbal dari Akar Manis (Glycyrrhiza glabra L.) untuk Pencegahan dan Pengobatan Infeksi Virus H1N1, H5N1 dan COVID-19: Systematic Review
Herbal Drug from Sweet Root (Glycyrrhiza glabra L.) for Prevention and Treatment of H1N1, H5N1 and COVID-19 Virus Infections: Systematic Review
DOI:
https://doi.org/10.33084/jsm.v8i1.2603Keywords:
Herbal medicin, Liquorice, Prevention, Treatment, Viral infection, H1N1, H5N1, COVID-19Abstract
Herbs have been used as a form of traditional medicine since ancient times. Licorice is one of the herbs that has long been used as medicine. This plant contains different plant compounds, such as glycyrrhizin, 18β‐glycyrrhetinic acid, glabrins A and B, and isoflavones, showing various pharmacological activities. Pharmacological experiments have shown that different extracts and pure compounds of this species exhibit broad biological properties, including antibacterial, anti-inflammatory, antiviral, antioxidant, and antidiabetic activities. This systematic review aims to determine the effectiveness of herbal medicine from licorice (Glycyrrhiza glabra L.) to prevent and treat H1N1, H5N1, and COVID-19 virus infections from various previous research results. This research is a systematic review using the PRISMA method. A total of 8 articles that met the inclusion and exclusion criteria were continued for analysis. A total of 8 articles discuss the effectiveness of licorice on the H1N1, H5N1, and COVID-19 viruses. The articles used include articles published in national journals and international journals. The results showed that 1) Licorice root is effectively used for the prevention and treatment of H1N1, H5N1, and COVID-19 virus infections, 2) Glycyrrhizic acid (GA) is the main compound for the development of potential anti-influenza virus agents. Overall, it can be concluded that licorice and some of its derivatives have the potential as anti-influenza agents for H1N1, H5N1, and COVID-19.
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2. Maqbool, M., Dar, M. A., Gani, I., Mir, S. A., & Khan, M. 2019. Herbal Medicines as an Alternative Source of Therapy: A Review. World Journal of
Pharmacy and Pharmaceutical Sciences, 8(2): 374-380. DOI:10.20959/wjpps20192-13108.
3. Parkash, J., Prasad, D. N., Shahnaz, M., & Dev, D. 2018. Herbs as Traditional Medicines: A Review. Journal of Drug Delivery and Therapeutics.8(5):146-150. DOI:http://dx.doi.org/10.22270/jddt.v8i5.1910.
4. Mamedov, N. A., & Egamberdieva, D. 2019. Phytochemical Constituents and Pharmacological Effects of Licorice: A Review. Plant and Human Health, (3):1–21. DOI:10.1007/978-3-030-04408-4
5. Onen, C. L. 2015. Epidemiology of Cardiovascular Toxins. Heart and Toxins, 1-44. DOI:10.1016/b978-0-12-416595-3.00001-3.
6. Dissanayake, K. G. C., Weerakoon, W. M. T. D.N., & Perera, W. P. R. T. 2020. Root/Stem Extracts of Glycyrrhiza glabra; As a Medicinal Plant Against Disease Forming Microorganisms. International Journal of Sciences: Basic and Applied Research (IJSBAR) 51(1):1-11.
7. Lateef Mousa, H. A. 2015. Prevention and treatment of viral infections by natural therapies. Journal of Prevention and Infection Control, 1(1). DOI:10.21767/2471-9668.10004.
8. Al-garawyi, A. M. A., Hussein, T. A., & Ali-Jassim, M. M. 2020. Inhibition of Viral Infection by Using of Natural Herbal Remedies as Alternative Treatment. Systematic Review Pharmacy, 11(6):416-419. DOI:10.31838/ srp.2020.6.66.
9. Ben-Shabat, S., Yarmolinsky, L., Porat, D., & Dahan, A. 2020. Antiviral effect of phytochemicals from medicinal plants: Applications and drug delivery strategies. Drug Delivery and Translational Research, 10:354–367. DOI: https://doi.org/10.1007/s13346-019-00691-6.
10. Chavan, R. D, Shinde, P., Girkar, K., Madage, R., & Chowdhary, A.. 2016. Assessment of Anti-Influenza activity and hemagglutination inhibition of Plumbago indica and Allium sativum extracts. Pharmacognosy Research, 8:105-11. DOI: 10.4103/0974-8490.172562
11. Brahmbhat, R. V. 2020. Herbal medicines in management and prevention of COVID-19. Journal of Pharmacognosy and Phytochemistry, 9(3):12211223.DOI:https://doi.org/10.22271/phyto.2020.v9.i3t.11460.
12. Moher, D., Shamseer, L., Clarke, M., Ghersi, D., Liberati, A., Petticrew, M., Shekelle, P., Stewart, LA., & PRISMA-P Group. 2015. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Systematic Reviews, 4(1). Available from: http://www.systematicreviewsjournal.com/content/4/1/1.
13. Liang, S., Li, M., Yu, X., Jin, H., Zhang, Y., Zhang, L., et al. 2019. Synthesis and structure-activity relationship studies of water-soluble β- cyclodextrin-glycyrrhetinic acid conjugates as potential anti-influenza virus agents. European Journal of Medicinal Chemistry, 166:328-338. DOI:10.1016/j.ejmech.2019.01.074.
14. Baltina, L. A., Zarubaev, V. V., Baltina, L. A., Orshanskaya, I. A., Fairushina, A. I., Kiselev, O. I., & Yunusov, M. S. 2015. Glycyrrhizic acid derivatives as influenza A/H1N1 virus inhibitors. Bioorganic & Medicinal Chemistry Letters, 25(8), 1742–1746. DOI:10.1016/j.bmcl.2015.02.074.
15. Ocampo, C. L., Tapia, G., Gutiérrez, L., & Sumano López, H. S. 2017. Effects of glycyrrhizic acid (Viusid- Vet® powder) on the reduction of influenza virus spread and on production parameters in pigs. Veterinari México OA, 4(1). DOI:10.21753/vmoa.4.1.373.
16. Ray, M., Sarkar, S., & Rath, S. N. 2020. Druggability for COVID-19: in silico discovery of potential drug compounds against nucleocapsid (N) protein of
17. Pariang, N. F. E., Wijaya, E., Sarnianto, P., Ikawati, Z., Lestari, K., Andrajati, R., dkk. 2020. Panduan Praktis untuk Apoteker. Menghadapi Pandemi COVID-19. Edisi Kedua. PT ISFI Penerbitan.
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