Formulation and Evaluation of Solid Dispersion Chitosan Tablet from Whiteleg Shrimp (Litopenaeus vannamei) Using PVP K-30 As a Carriers
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Tablet, Solid Dispersion, Chitosan, Whiteleg Shrimp, PVP K-30
Abstract
Whiteleg shrimp (Litopenaeus vannamei) on the market are processed or sold only to take part in the meat. The head, shell, and tail are thrown away without any prior processing. Underutilized waste causes environmental problems. An alternative to overcome this environmental disturbance phenomenon is to utilize shrimp shells containing chitin and subsequently transformed into chitosan that can be applied in various fields. Chitosan has poor solubility in water but high permeability; thus, improve bioavailability is accomplished by making solid dispersions. This study aims to formulate and evaluate the solid dispersion tablet using chitosan extract from L. vannamei as an active agent with PVP K-30 as a carrier. The formulation divided into three groups, that was F1 (chitosan : PVP K-30 = 1 : 1 solid dispersion), F2 (chitosan : PVP K-30 = 1 : 3 solid dispersion), and F3 (pure chitosan). The result of chitosan solid dispersion was molded into tablets by the direct compression method. The tablets were evaluated by weight and size uniformity, hardness, friability, and disintegration time. All the formulas by weight and size uniformity as well as disintegration time fulfill the requirements. The hardness of the tablets from F3 with 4,275 kg was the best from F1 and F2. By statistic analytical from weight uniformity, hardness and disintegration time give significant difference with sig. <0.05.
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References
2. Khoushab F, Yamabhai M. Chitin Research Revisited. Mar Drugs. 2010;8(7):1988-2012. doi:10.3390/md8071988
3. Badan Karantina Ikan, Pengendalian Mutu dan Keamanan Hasil Perikanan. Peta Lalulintas Benih Ikan dan Benur Udang Nasional 2018 [Internet]. Jakarta, Indonesia: Badan Karantina Ikan, Pengendalian Mutu dan Keamanan Hasil Perikanan; 2018 [updated 2018; cited 2020 Jul 23]. Available from: https://kkp.go.id/bkipm/artikel/5880-peta-lalulintas-benih-ikan-dan-benur-udang-nasional-2018
4. Santos VP, Marques NSS, Maia PCSV, de Lima MAB, Franco LO, de Campos-Takaki GM. Seafood Waste as Attractive Source of Chitin and Chitosan Production and Their Applications. Int J Mol Sci. 2020;21(12):4290. doi:10.3390/ijms21124290
5. Kurakula M, Raghavendra NN. Prospection of recent chitosan biomedical trends: Evidence from patent analysis (2009–2020). Int J Biol Macromol. 2020;165(B):1924-38. doi:10.1016/j.ijbiomac.2020.10.043
6. Ylitalo R, Lehtinen S, Wuolijoki E, Ylitalo P, Lehtimäki T. Cholesterol-lowering properties and safety of chitosan. Arzneimittelforschung. 2002;52(1):1-7. doi:10.1055/s-0031-1299848
7. Jing SB, Li L, Ji D, Takiguchi Y, Yamaguchi T. Effect of chitosan on renal function in patients with chronic renal failure. J Pharm Pharmacol. 1997;49(7):721-3. doi:10.1111/j.2042-7158.1997.tb06099.x
8. Wardiyah, Asyarie S, Wikarsa S. Pembuatan dan Karakterisasi Dispersi Padat Sistem Biner dan Terner dari Gliklazid. Acta Pharm Indo. 2012;37(3):95-101.
9. Vasconcelos T, Sarmento B, Costa P. Solid dispersions as strategy to improve oral bioavailability of poor water soluble drugs. Drug Discov Today. 2007;12(23-24):1068-75. doi:10.1016/j.drudis.2007.09.005
10. Rowe RC, Sheskey PJ, Owen SC. Handbook of Pharmaceutical Excipients. 6th edition. Michigan, US: Pharmaceutical Press; 2009.
11. Siregar EC, Suryati S, Hakim L. Pengaruh Suhu dan Waktu Reaksi pada Pembuatan Kitosan dari Tulang Sotong (Sepia officinalis). Jurnal Teknologi Kimia Unimal. 2016;5(2):37-44. doi:10.29103/jtku.v5i2.88
12. Agustina S, Swantara IMD, Suartha IN. Isolasi Kitin, Karakterisasi, dan Sintesis Kitosan dari Kulit Udang. Jurnal Kimia J Chem. 2015;9(2):271-8. doi:10.24843/JCHEM.2015.v09.i02.p19
13. Harjanti RS. Kitosan dari Limbah Udang sebagai Bahan Pengawet Ayam Goreng. Jurnal Rekayasa Proses. 2014;8(1):12-9. doi:10.22146/jrekpros.5018
14. Khan TA, Peh KK, Ch’ng HS. Reporting degree of deacetylation values of chitosan: the influence of analytical methods. J Pharm Pharm Sci. 2002;5(3):205-12.
15. Tokatli K, Demirdöven A. Optimization of chitin and chitosan production from shrimp wastes and characterization. J Food Process Preserv. 2017;42(2): e13494. doi:10.1111/jfpp.13494
16. Hossain MS, Iqbal A. Production and characterization of chitosan from shrimp waste. J Bangladesh Agril Univ. 2014;12(1):153-60. doi:10.3329/jbau.v12i1.21405
17. Zaini E, Novitasari N, Octavia MD. Pembentukan Sistem Dispersi Padat Amorf Azitromisin Dihidrat dengan Hikroksipropil Metilselulosa (HPMC). JSFK Jurnal Sains Farmasi & Klinis. 2017;3(2):165-71. doi:10.29208/jsfk.2017.3.2.140
18. Ministry of Health of the Republic of Indonesia. Farmakope Indonesia Edisi V. Jakarta, Indonesia: Ministry of Health of the Republic of Indonesia; 2014.
19. Yanti R, Drastinawati D, Yusnimar Y. Sintesis Kitosan Dari Limbah Cangkang Kepiting Dengan Variasi Suhu Dan Waktu Pada Proses Deasetilasi. JOM FT Universitas Riau. 2018;5(2):1-7.
20. Dompeipen EJ, Kaimudin M, Dewa RP. Isolasi Kitin dan Kitosan dari Limbah Kulit Udang. Majalah BIAM. 2016;12(1):32-9. doi:10.29360/mb.v12i1.2326
21. Zahiruddin W, Ariesta A, Salamah E. Characteristics of Quality and Solubility Kitosan From Head of Shrimp (Penaeus Monodon) Silase Dregs. Jurnal Pengolahan Hasil Perikanan Indonesia. 2008;11(2):25-9. doi:10.17844/jphpi.v11i2.917
22. Lachman L, Lieberman HA, Kanig JL. Teori dan Praktek Industri Farmasi. 3rd edition. Jakarta, Indonesia: Universitas Indonesia Press; 2008.
23. Fuhrman Jr LC. Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems, 8th Edition. Am J Pharm Educ. 2006;70(3):71.
24. Iqubal MK. Recent Advances in Direct Compression Technique for Pharmaceutical Tablet Formulation. Int J Pharm Res Dev. 2014;6(1):49-57.
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