Role of Cannabinoid Receptors in Psychological Disorder
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Submitted
29 July 2020
Published
30 November 2020
Keywords:
-
Endocannabinoid, Neurochemical, CB1 receptors, CB2 receptors, Anxiety, Alzheimer
Abstract
Cannabinoid receptors, located throughout the body, are part of the endocannabinoid system. Cannabinoid CB1 and CB2 receptors are G protein-coupled receptors present from the early stages of gestation, which is involved in various physiological processes, including appetite, pain-sensation, mood, and memory. Due to the lipophilic nature of cannabinoids, it was initially thought that these compounds exert several biological effects by disrupting the cell membrane nonspecifically. Recent biochemical and behavioral findings have demonstrated that blockade of CB1 receptors engenders antidepressant-like neurochemical changes (increases in extracellular levels of monoamines in cortical but not subcortical brain regions) and behavioral effects consistent with antidepressant/antistress activity. We aim to define various roles of cannabinoid receptors in modulating signaling pathways and association with several pathophysiological conditions.
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References
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Cassano, T., Calcagnini, S., Pace L., De Marco, F., Romano, A., & Gaetani, S. (2017). Cannabinoid Receptor 2 Signaling in Neurodegenerative Disorders: From Pathogenesis to a Promising Therapeutic Target. Frontiers in Neuroscience, 11, 30. doi:10.3389/fnins.2017.00030
Castillo, P.E., Younts, T.J., Chávez, A.E., & Hashimotodani, Y. (2012). Endocannabinoid signaling and synaptic function. Neuron, 76(1), 70-81. doi:10.1016/j.neuron.2012.09.020
Ceulemans, B., Boel, M., Leyssens, K., Van Rossem, C., Neels, P., Jorens, P.G., & Lagae, L. (2012). Successful use of fenfluramine as an add-on treatment for Dravet syndrome. Epilepsia, 53(7), 1131-1139. doi:10.1111/j.1528-1167.2012.03495.x
Di Marzo, V., Hill, M.P., Bisogno, T., Crossman, A.R., & Brotchie, J.M. (2000). Enhanced levels of endogenous cannabinoids in the globus pallidus are associated with a reduction in movement in an animal model of Parkinson's disease. The FASEB Journal, 14(10), 1432-1438. doi:10.1096/fj.14.10.1432
Donvito, G., Nass, S.R., Wilkerson, J.L., Curry, Z.A., Schurman, L.D., Kinsey, S.G., & Lichtman, A.H. (2018). The Endogenous Cannabinoid System: A Budding Source of Targets for Treating Inflammatory and Neuropathic Pain. Neuropsychopharmacology, 43, 52-79. doi:10.1038/npp.2017.204
Dhopeshwarkar, A. & Mackie, K. (2014). CB2 Cannabinoid Receptors as a Therapeutic Target—What Does the Future Hold? Molecular Pharmacology, 86(4), 430-437. doi:10.1124/mol.114.094649
Harvey, R.J., Carta, E., Pearce, B.R., Chung, S.K., Supplisson, S., Rees, M.I., & Harvey, K. (2008). A Critical Role for Glycine Transporters in Hyperexcitability Disorders. Frontiers in Molecular Neuroscience, 1, 1. doi:10.3389/neuro.02.001.2008
Hasler, G. (2010). Pathophysiology of Depression: Do We Have Any Solid Evidence of Interest to Clinicians? World Psychiatry, 9(3), 155-161. doi:10.1002/j.2051-5545.2010.tb00298.x
Herman, J.P., McKlveen, J.M., Ghosal, S., Kopp, B., Wulsin, A., Makinson, R., Scheimann, J., & Myers, B. (2016). Regulation of the hypothalamic-pituitary-adrenocortical stress response. Comprehensive Physiology, 6(2), 603-621. doi:10.1002/cphy.c150015
Hill, M.N., Campolongo, P., Yehuda, R., & Patel, S. (2018). Integrating Endocannabinoid Signaling and Cannabinoids into the Biology and Treatment of Posttraumatic Stress Disorder. Neuropsychopharmacology, 43(1), 80-102. doi:10.1038/npp.2017.162
Howlett, A.C. & Abood, M.E. (2017). CB1 & CB2 Receptor Pharmacology. Advances in Pharmacology, 80, 169-206. doi:10.1016/bs.apha.2017.03.007
Ibarra-Lecue, I., Pilar-Cuéllar, F., Muguruza, C., Florensa-Zanuy, E., Díaz, Á., Urigüen, L., Castro, E., Pazos, A., & Callado, L.F. (2018). The endocannabinoid system in mental disorders: Evidence from human brain studies. Biochemical Pharmacology, 157, 97-107. doi:10.1016/j.bcp.2018.07.009
Kano, M. (2014). Control of synaptic function by endocannabinoid-mediated retrograde signaling. Proceedings of the Japan Academy Series B: Physical and Biological Sciences, 90(7), 235-250. doi:10.2183/pjab.90.235
Kayser, R.R., Snorrason, I., Haney, M., Lee, F.S., & Simpson, H.B. (2019). The Endocannabinoid System: A New Treatment Target for Obsessive Compulsive Disorder? Cannabis and Cannabinoid Research, 4(2), 77-87. doi:10.1089/can.2018.0049
Kimura, T., Takaya, M., Usami, N., Watanabe, K., & Yamamoto, I. (2019). ∆9-Tetrahydrocannabinol, a major marijuana component, enhances the anesthetic effect of pentobarbital through the CB1 receptor. Forensic Toxicology, 37(1), 207-214. doi:10.1007/s11419-018-0457-2
Lac, A. & Luk, J.W. (2018). Testing the Amotivational Syndrome: Marijuana Use Longitudinally Predicts Lower Self-Efficacy Even After Controlling for Demographics, Personality, and Alcohol and Cigarette Use. Prevention Science, 19(2), 117-126. doi:10.1007/s11121-017-0811-3
Lawn, W., Freeman, T.P., Pope, R.A., Joye, A., Harvey, L., Hindocha, C., Mokrysz, C., Moss, A., Wall, M.B., Bloomfield, M.A., Das, R.K., Morgan, C.J., Nutt, D.J., & Curran, V. (2016). Acute and chronic effects of cannabinoids on effort-related decision-making and reward learning: an evaluation of the cannabis 'amotivational' hypotheses. Psychopharmacology, 233(19-20), 3537-3552. doi:10.1007/s00213-016-4383-x
Lee, J.L.C., Bertoglio, L.J., Guimarães, F.S., & Stevenson, C.W. (2017). Cannabidiol regulation of emotion and emotional memory processing: relevance for treating anxiety‐related and substance abuse disorders. British Journal of Pharmacology, 174(19), 3242-3256. doi:10.1111/bph.13724
Lépine, J.P. & Briley, M. (2011). The increasing burden of depression. Neuropsychiatric Disease and Treatment, 7(Suppl 1), 3-7. doi:10.2147/NDT.S19617
Leweke, F.M., Piomelli, D., Pahlisch, F., Muhl, D., Gerth, C.W., Hoyer, C., Klosterkötter,J., Hellmich, M., & Koethe, D. (2012). Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia. Translational Psychiatry, 2(3), e94. doi:10.1038/tp.2012.15
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Jha AN, Patel DM. Role of Cannabinoid Receptors in Psychological Disorder. Borneo J Pharm [Internet]. 2020Nov.30 [cited 2024Dec.21];3(4):199-208. Available from: https://journal.umpr.ac.id/index.php/bjop/article/view/1569
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