Identification of Drug-Related Problems in Hypertension Comorbid Type 2 Diabetes Mellitus Patients at Primary Health Care Center Batununggal District Bandung
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Submitted
6 January 2021
Published
30 August 2021
Keywords:
-
Drug related problems, Hypertension, Type 2 diabetes mellitus
Abstract
Many factors can increase the risk of hypertension, one of which is diabetes mellitus. The study aims to provide an overview of Drug-Related Problems (DRPs) in patients with hypertension comorbid type 2 diabetes mellitus at Primary Health Care Center Batununggal District Bandung. This research was an observational study with retrospective data collection and descriptive analysis. Data were taken from patient prescriptions January-December 2019 period. The sample inclusion criteria are patients aged 30-75 years, patients diagnosed with hypertension comorbid type 2 diabetes mellitus, and patients treated in January-December 2019. The number of samples that met the inclusion criteria was 268 patients, of which 69 patients (25.75%) are male, and 199 patients (74.25%) are female. 164 patients (61.2%) are aged 60-75 years old. It is found that 1 case (0.37%) has the drug-related problem of drug overdose and as many as 34 cases (12.69%) have potential drug interactions.
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References
1. Petrie JR, Guzik TJ, Touyz RM. Diabetes, Hypertension, and Cardiovascular Disease: Clinical Insights and Vascular Mechanisms. Can J Cardiol. 2018;34(5):575-84. doi:10.1016/j.cjca.2017.12.005
2. Akalu Y, Belsti Y. Hypertension and Its Associated Factors Among Type 2 Diabetes Mellitus Patients at Debre Tabor General Hospital, Northwest Ethiopia. Diabetes Metab Syndr Obes. 2020;13:1621-31. doi:10.2147/DMSO.S254537
3. Ohishi M. Hypertension with diabetes mellitus: physiology and pathology. Hypertens Res. 2018;41(6):389-93. doi:10.1038/s41440-018-0034-4
4. Einarson TR, Acs A, Ludwig C, Panton UH. Prevalence of cardiovascular disease in type 2 diabetes: a systematic literature review of scientific evidence from across the world in 2007–2017. Cardiovasc Diabetol. 2018;17:83. doi:10.1186/s12933-018-0728-6
5. Guerrero-García C, Rubio-Guerra AF. Combination therapy in the treatment of hypertension. Drugs Context. 2018;7:212531. doi:10.7573/dic.212531
6. Al-Azzam SI, Alzoubi KH, AbuRuz S, Alefan Q. Drug-related problems in a sample of outpatients with chronic diseases: a cross-sectional study from Jordan. Ther Clin Risk Manag. 2016;12:233-9. doi:10.2147/tcrm.s98165
7. Anshila MK, Nambiar DP, Augustine DV, Saseendran M, Shabraya AR, Siva S. Evaluation of Drug Related Problems in Patients with Chronic Disease at Tertiary Care Teaching Hospital. Int J Health Sci Res. 2020;10(9):144-55.
8. Septiani V, Sutjiatmo AB, Rustam LD. Identification of Drug-Related Problems (DRPs) Antihypertension on Hypertension Patient with Hyperlipidemia at One of Puskesmas in Bandung. In Asian Federation for Pharmaceutical Sciences (AFPS) 2019. Depok: Universitas Indonesia.
9. DiPiro JT, Yee GC, Posey M, Haines ST, Nolin TD, Ellingrod V. Pharmacotherapy: A Pathophysiologic Approach. 11th ed. New York: McGraw Hill Professional; 2020.
10. Ministry of Health Republic of Indonesia. Hasil Utama Riskesdas 2018. Jakarta: Health Research and Development Agency, Ministry of Health Republic of Indonesia; 2018.
11. Sabbatini AR, Kararigas G. Estrogen-related mechanisms in sex differences of hypertension and target organ damage. Biol Sec Differ. 2020;11:31. doi:10.1186/s13293-020-00306-7
12. Singh S, Shankar R, Singh GP. Prevalence and Associated Risk Factors of Hypertension: A Cross-Sectional Study in Urban Varanasi. Int J Hypertens. 2017;2017:5491838. doi:10.1155/2017/5491838
13. Nishiwaki M, Yonemura H, Kurobe K, Matsumoto N. Four weeks of regular static stretching reduces arterial stiffness in middle-aged men. Springerplus. 2015;4:555. doi:10.1186/s40064-015-1337-4
14. Qiu L, Wang W, Sa R, Liu F. Prevalence and Risk Factors of Hypertension, Diabetes, and Dyslipidemia among Adults in Northwest China. 2021;2021:5528007. doi:10.1155/2021/5528007
15. Yimama M, Jarso H, Desse TA. Determinants of drug-related problems among ambulatory type 2 diabetes patients with hypertension comorbidity in Southwest Ethiopia: a prospective cross sectional study. BMC Res Notes. 2018;11:679. doi:10.1186/s13104-018-3785-8
16. Tardy AL, Pouteau E, Marquez D, Yilmaz C, Scholey A. Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence. Nutrients. 2020;12(1):228. doi:10.3390/nu12010228
17. Moretti R, Caruso P. The Controversial Role of Homocysteine in Neurology: From Labs to Clinical Practice. Int J Mol Sci. 2019;20(1):231. doi:10.3390/ijms20010231
18. Tinelli C, Di Pino A, Ficulle E, Marcelli S, Feligioni M. Hyperhomocysteinemia as a Risk Factor and Potential Nutraceutical Target for Certain Pathologies. Front Nutr. 2019;6:49. doi:10.3389/fnut.2019.00049
19. Fu J, Liu Y, Zhang L, Zhou L, Li D, Quan H, et al. Nonpharmacologic Interventions for Reducing Blood Pressure in Adults with Prehypertension to Established Hypertension. J Am Heart Assoc. 2020;9(19):e016804. doi:10.1161/jaha.120.016804
20. Carey RM, Muntner P, Bosworth HB, Whelton PK. Prevention and Control of Hypertension: JACC Health Promotion Series. J Am Coll Cardiol. 2018;72(11):1278-93. doi:10.1016/j.jacc.2018.07.008
21. Mahmood S, Shah KU, Khan TM, Nawaz S, Rashid H, Baqar SWA, et al. Non-pharmacological management of hypertension: in the light of current research. Ir J Med Sci. 2019;188(2):437-52. doi:10.1007/s11845-018-1889-8
22. Fares H, DiNicolantonio JJ, O’Keefe JH, Lavie CJ. Amlodipine in hypertension: a first-line agent with efficacy for improving blood pressure and patient outcomes. Open Heart. 2016;3(2):e000473. doi:10.1136/openhrt-2016-000473
23. Wongrakpanich S, Wongrakpanich A, Melhado K, Rangaswami J. A Comprehensive Review of Non-Steroidal Anti-Inflammatory Drug Use in The Elderly. Aging Dis. 2018;9(1):143-50. doi:10.14336/AD.2017.0306
24. Baxter, K. Stockley’s Drug Interactions. 8th ed. London: Pharmaceutical Press; 2008. p. 861-863.
25. George J, MacDonald T. Home Blood Pressure Monitoring. Eur Cardiol. 2015;10(2):95-101. doi:10.15420/ecr.2015.10.2.95
26. Garin N, Sole N, Lucas B, Matas L, Moras D, Rodrigo-Troyano A, et al. Drug related problems in clinical practice: a cross-sectional study on their prevalence, risk factors and associated pharmaceutical interventions. Sci Rep. 2021;11:883. doi:10.1038/s41598-020-80560-2
27. Farha RA, Saleh A, Aburuz S. The impact of drug related problems on health-related quality of life among hypertensive patients in Jordan. Pharm Pract. 2017;15(3):995. doi:10.18549/PharmPract.2017.03.995
28. Huri ZH, Wee HF. Drug related problems in type 2 diabetes patients with hypertension: a cross-sectional retrospective study. BMC Endocr Disord. 2013;13:2. doi:10.1186/1472-6823-13-2
2. Akalu Y, Belsti Y. Hypertension and Its Associated Factors Among Type 2 Diabetes Mellitus Patients at Debre Tabor General Hospital, Northwest Ethiopia. Diabetes Metab Syndr Obes. 2020;13:1621-31. doi:10.2147/DMSO.S254537
3. Ohishi M. Hypertension with diabetes mellitus: physiology and pathology. Hypertens Res. 2018;41(6):389-93. doi:10.1038/s41440-018-0034-4
4. Einarson TR, Acs A, Ludwig C, Panton UH. Prevalence of cardiovascular disease in type 2 diabetes: a systematic literature review of scientific evidence from across the world in 2007–2017. Cardiovasc Diabetol. 2018;17:83. doi:10.1186/s12933-018-0728-6
5. Guerrero-García C, Rubio-Guerra AF. Combination therapy in the treatment of hypertension. Drugs Context. 2018;7:212531. doi:10.7573/dic.212531
6. Al-Azzam SI, Alzoubi KH, AbuRuz S, Alefan Q. Drug-related problems in a sample of outpatients with chronic diseases: a cross-sectional study from Jordan. Ther Clin Risk Manag. 2016;12:233-9. doi:10.2147/tcrm.s98165
7. Anshila MK, Nambiar DP, Augustine DV, Saseendran M, Shabraya AR, Siva S. Evaluation of Drug Related Problems in Patients with Chronic Disease at Tertiary Care Teaching Hospital. Int J Health Sci Res. 2020;10(9):144-55.
8. Septiani V, Sutjiatmo AB, Rustam LD. Identification of Drug-Related Problems (DRPs) Antihypertension on Hypertension Patient with Hyperlipidemia at One of Puskesmas in Bandung. In Asian Federation for Pharmaceutical Sciences (AFPS) 2019. Depok: Universitas Indonesia.
9. DiPiro JT, Yee GC, Posey M, Haines ST, Nolin TD, Ellingrod V. Pharmacotherapy: A Pathophysiologic Approach. 11th ed. New York: McGraw Hill Professional; 2020.
10. Ministry of Health Republic of Indonesia. Hasil Utama Riskesdas 2018. Jakarta: Health Research and Development Agency, Ministry of Health Republic of Indonesia; 2018.
11. Sabbatini AR, Kararigas G. Estrogen-related mechanisms in sex differences of hypertension and target organ damage. Biol Sec Differ. 2020;11:31. doi:10.1186/s13293-020-00306-7
12. Singh S, Shankar R, Singh GP. Prevalence and Associated Risk Factors of Hypertension: A Cross-Sectional Study in Urban Varanasi. Int J Hypertens. 2017;2017:5491838. doi:10.1155/2017/5491838
13. Nishiwaki M, Yonemura H, Kurobe K, Matsumoto N. Four weeks of regular static stretching reduces arterial stiffness in middle-aged men. Springerplus. 2015;4:555. doi:10.1186/s40064-015-1337-4
14. Qiu L, Wang W, Sa R, Liu F. Prevalence and Risk Factors of Hypertension, Diabetes, and Dyslipidemia among Adults in Northwest China. 2021;2021:5528007. doi:10.1155/2021/5528007
15. Yimama M, Jarso H, Desse TA. Determinants of drug-related problems among ambulatory type 2 diabetes patients with hypertension comorbidity in Southwest Ethiopia: a prospective cross sectional study. BMC Res Notes. 2018;11:679. doi:10.1186/s13104-018-3785-8
16. Tardy AL, Pouteau E, Marquez D, Yilmaz C, Scholey A. Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence. Nutrients. 2020;12(1):228. doi:10.3390/nu12010228
17. Moretti R, Caruso P. The Controversial Role of Homocysteine in Neurology: From Labs to Clinical Practice. Int J Mol Sci. 2019;20(1):231. doi:10.3390/ijms20010231
18. Tinelli C, Di Pino A, Ficulle E, Marcelli S, Feligioni M. Hyperhomocysteinemia as a Risk Factor and Potential Nutraceutical Target for Certain Pathologies. Front Nutr. 2019;6:49. doi:10.3389/fnut.2019.00049
19. Fu J, Liu Y, Zhang L, Zhou L, Li D, Quan H, et al. Nonpharmacologic Interventions for Reducing Blood Pressure in Adults with Prehypertension to Established Hypertension. J Am Heart Assoc. 2020;9(19):e016804. doi:10.1161/jaha.120.016804
20. Carey RM, Muntner P, Bosworth HB, Whelton PK. Prevention and Control of Hypertension: JACC Health Promotion Series. J Am Coll Cardiol. 2018;72(11):1278-93. doi:10.1016/j.jacc.2018.07.008
21. Mahmood S, Shah KU, Khan TM, Nawaz S, Rashid H, Baqar SWA, et al. Non-pharmacological management of hypertension: in the light of current research. Ir J Med Sci. 2019;188(2):437-52. doi:10.1007/s11845-018-1889-8
22. Fares H, DiNicolantonio JJ, O’Keefe JH, Lavie CJ. Amlodipine in hypertension: a first-line agent with efficacy for improving blood pressure and patient outcomes. Open Heart. 2016;3(2):e000473. doi:10.1136/openhrt-2016-000473
23. Wongrakpanich S, Wongrakpanich A, Melhado K, Rangaswami J. A Comprehensive Review of Non-Steroidal Anti-Inflammatory Drug Use in The Elderly. Aging Dis. 2018;9(1):143-50. doi:10.14336/AD.2017.0306
24. Baxter, K. Stockley’s Drug Interactions. 8th ed. London: Pharmaceutical Press; 2008. p. 861-863.
25. George J, MacDonald T. Home Blood Pressure Monitoring. Eur Cardiol. 2015;10(2):95-101. doi:10.15420/ecr.2015.10.2.95
26. Garin N, Sole N, Lucas B, Matas L, Moras D, Rodrigo-Troyano A, et al. Drug related problems in clinical practice: a cross-sectional study on their prevalence, risk factors and associated pharmaceutical interventions. Sci Rep. 2021;11:883. doi:10.1038/s41598-020-80560-2
27. Farha RA, Saleh A, Aburuz S. The impact of drug related problems on health-related quality of life among hypertensive patients in Jordan. Pharm Pract. 2017;15(3):995. doi:10.18549/PharmPract.2017.03.995
28. Huri ZH, Wee HF. Drug related problems in type 2 diabetes patients with hypertension: a cross-sectional retrospective study. BMC Endocr Disord. 2013;13:2. doi:10.1186/1472-6823-13-2
Authors
1.
Septiani V, Kartidjo P, Islamiyah AN, Aziz MSW A, Rukmawati I. Identification of Drug-Related Problems in Hypertension Comorbid Type 2 Diabetes Mellitus Patients at Primary Health Care Center Batununggal District Bandung. Borneo J Pharm [Internet]. 2021Aug.30 [cited 2025Mar.16];4(3):219-25. Available from: https://journal.umpr.ac.id/index.php/bjop/article/view/1971
Copyright (c) 2021 Vina Septiani, Pudjiastuti Kartidjo, Alfi Nurul Islamiyah, Abdul Aziz MSW, Iis Rukmawati
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