Acne is the condition of abnormal skin which is indicated by inflammation caused by the bacterial infection of Propionibacterium acnes. The natural one which can be used for the medical treatment of acne is the snail mucus (Achatina fulica). The achasin protein of it has antibacterial activity. That snail mucus was made to the emulgel form. This research has used an experimental method and the emulgel formulation used the various concentration of emulsifying agents and the gelling agent. They were Tween 80 1.76%, 2.44%, 3.12%, Span 80 2.24%, 4.06%, 5.88% and HPMC 3.5%, 4.5%, 5.5%. Other additives were propylene glycol, Methylparaben, Propylparaben, paraffin liquid, menthol, and aquadest. Those formulations were tested in physical evaluation during 4 weeks of storage in room temperature, irritation test, hedonic test, and cycling test. The organoleptic test showed that the emulgel were the milk-white color with a distinctive smell. All emulgel were homogenous, non-irritant, with emulsion type oil in water (o/w). This emulgel also met the normal skin of pH value and spread ability’s range. The emulgel viscosity shift was < 10%, with the viscosity value inversely proportional to spreadability. Formula C with 3.12% of Tween 80, 5.88% of Span 80 and 5.5% of HPMC was claimed as the most stable formula both in room temperature and after cycling test. It was also the most preferred by the panelist.
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Dewi, S.A. 2009. Cara Ampuh Mengobati Jerawat Secara Alami dan Medis. Buana Pustaka, Yogyakarta.
Erawati, T., Rosita, N., Hendroprasetyo, W., Juwita, D. R. 2005. Pengaruh Jenis Basis Gel Dan Penambahan NaCl (0.5% -b/b) Terhadap Intensitas Echo Gelombang Ultrasonik Sediaan Gel Untuk Pemeriksaan USG (Acoustic Coupling Agent). Airlangga Journal of Pharmacy. 5(2).
Garg, A., Aggrawal, D., Garg, S., Singla, A.K. 2002. Spreading of Semisolid Formulations: An Update. Pharmaceutical Technology. pp 84-105.
Kim, C. 2004. Advanced Pharmaceutics Physicochemical Principles. CRC Press, London.
Laverius, M.F. 2011. Optimasi Tween 80 Dan Span 80 Sebagai Emulsifying Agent Serta Carbopol Sebagai Gelling Agent Dalam Sediaan Emulgel Photoprotector Ekstrak Teh Hijau (Camellia sinensis L.): Aplikasi Desain Faktorial. Skripsi. Universitas Sanata Dharma, Yogyakarta.
Mardiana, Z.H., Amila, G. dan Lanny, M. 2015. Formulasi Gel yang Mengandung Lendir Bekicot (Achatina fulica) Serta Uji Aktivitas Antibakteri Terhadap Propionibacterium acne. Prosiding Penelitian Spesia UNISBA Farmasi Gelombang 2 (2014-2015), pp 223-224.
Rowe, R.C., Paul, J.S., Sian, C.O. 2009. Handbook of Pharmaceutical Excipients 6th Edition. Pharmaceutical Press, Washington D.C.
Syukri, Y., Sari, F., Zahliyatul, S. 2009. Stabilitas Fisik Emulsi Ganda Virgin Coconut Oil (VCO) Menggunakan Emulgator Span 80 dan Tween 40. Jurnal Ilmiah Farmasi. 5(1):4.
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