Effect of Giving Celecoxib on Uric Acid Level on Mice

Sara Surya (1)
(1) Universitas Dharma Andalas , Indonesia


Celecoxib is a breakthrough for pain relievers under the trade name Celebrex®, which is a Non-Steroid Anti-Inflammatory drug with its activity as an analgesic, antipyretic and anti-inflammatory. The purpose of this study was to find out the effect of celecoxib on blood uric acid levels of female white mice was induced with fresh cow liver extract. Experimental animals were divided into five groups, namely the control group (-), the control group (+) and the three dose groups, respectively 0.26, 0.52 and 1.04 mg/20 g. Observations were made on 7, 14 and 21 days with the Enzymatic Photometric method. The results showed that administration of celecoxib suspension at a dose of 0.26, 0.52 and 1.04 mg/20 g did not affect blood uric acid levels when compared with controls (P> 0.05).

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Meek, I.L., van de Laar, M.A.F.J., Vonkeman, H.E. 2010. Non-Steroidal Anti-Inflammatory Drugs: An Overview of Cardiovascular Risks. Pharmaceuticals. 3(7):2146-2162.
Raval, M.K., Sathesh Babu, P.R., Thimmasetty, J., Parikh, R.K., Sheth, N.R., Subrahmanyam, C.V.S. 2010. Influence of solvents on the crystal habit and properties of rofecoxib and celecoxib: No evidence of polymorphism. Journal of Pharmaceutical Negative Results. 1(2):40-50.
Zarghi, A., Arfaei, S. 2011. Selective COX-2 Inhibitors: A Review of Their Structure-Activity Relationships. Iranian Journal of Pharmaceutical Research. 10(4):655-683.
Hediger, M.A. 2004. Physiology and biochemistry of uric acid. Therapeutische Umschau. 61(9):541-545.
Murray, R.K. 2012. Harper's illustrated biochemistry (29th ed.). New York: McGraw-Hill Medical.
Suyono, S. 2001. Buku Ajar Penyakit Dalam (3rd ed.). Jakarta Fakultas Kedokteran Universitas Indonesia.
Milind, P., Sushila, K., Neeraj, S. 2013. Understanding Gout Beyond Doubt. International Research Journal of Pharmacy. 4(9):25-34.
Ong, C.K.S., Lirk, P., Tan, C.H., Seymour, R.A. 2007. An Evidence-Based Update on Nonsteroidal Anti-Inflammatory Drugs. Clinical Medicine & Research. 5(1):19-34.
Zarraga, I.G.E., Schwarz, E.R. 2007. Coxibs and Heart Disease: What We Have Learned and What Else We Need to Know. Journal of The American College of Cardiology. 49(1):1-14.
Lascelles, B.D.X., Court, M.H., Hardie, E.M., Robertson, S.A. 2007. Nonsteroidal anti-inflammatory drugs in cats: a review. Veterinary Anaesthesia and Analgesia. 34:228-250.
Pasalic, D., Marinkovic, N., Feher-Turkovic, L. 2012. Uric acid as one of the important factors in multifactorial disorders – facts and controversies. Biochemia Medica. 22(1):63-75.
Burns, C.M., Wortmann, R.L. 2012. Latest evidence on gout management: what the clinician needs to know. Therapeutic Advances in Chronic Disease. 3(6):271-286.


Sara Surya
sar4surya@gmail.com (Primary Contact)
Author Biography

Sara Surya, Universitas Dharma Andalas

Surya S. Effect of Giving Celecoxib on Uric Acid Level on Mice. Borneo J Pharm [Internet]. 2018Nov.1 [cited 2024Jun.14];1(2):61-3. Available from: https://journal.umpr.ac.id/index.php/bjop/article/view/371

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