Aloe vera Gel Ameliorates Fat-Rich and High Fructose (FRHF) Diet-Induced Pancreatic and Splenic Damage in Mice

Nathan Isaac Dibal (1) , Zainab Muhammad Goni (2) , Martha Orendu Oche Attah (3) , Umar Imam (4) , Muhammad Abdullahi (5) , Muzammil Bashir (6) , Usman Adam (7) , Fatima Aisami (8) , Mohammed Shuwa (9) , Sunday Joseph Manye (10) , Madu Nom Gadzama (11) , Musa Samaila Chiroma (12) , Helga Bedan Ishaya (13)
(1) University of Maiduguri , Nigeria
(2) University of Maiduguri , Nigeria
(3) Cyprus International University , Cyprus
(4) University of Maiduguri , Nigeria
(5) University of Maiduguri , Nigeria
(6) University of Maiduguri , Nigeria
(7) University of Maiduguri , Nigeria
(8) University of Maiduguri , Nigeria
(9) University of Maiduguri , Nigeria
(10) University of Maiduguri , Nigeria
(11) University of Maiduguri , Nigeria
(12) Newcastle University Medicine Malaysia , Malaysia
(13) University of Maiduguri , Nigeria

Abstract

High-fat diet alone or in combination with high fructose has been known to induce diabetes, obesity, hypertension, and immune dysfunction. The study evaluates the role of Aloe vera in fat-rich and high fructose diet-induced (FRHFD) hyperglycemias in addition to testicular and splenic morphology in mice. Twenty BALB/c Mice were randomly distributed into four groups (n=5). The groups were fed on a normal diet, FRHFD, FRHFD + 10 g A. vera, and FRHFD + 20 g A. vera for 10 weeks. All the mice were sacrificed a day after the 10 weeks of treatment. The result showed that mice fed on FRHFD plus A. vera had a significantly lower (p<0.05) blood glucose level relative to the FRHFD-fed mice. The mice fed on FRHFD plus A. vera had a significantly lower (p<0.05) blood glucose level relative to the FRHFD-fed mice. Aloe vera was found to ameliorate FRHFD-induced pancreatic islet and acini damage. It also prevented distorted lymphoid cells and testicular damage induced by FRHFD. Aloe vera prevents hyperglycemia and protects pancreatic islets in FRHFD-fed mice. It further prevents immune dysfunction and protects against testicular damage. Hence, A. vera supplementation could be an alternative and/or complementary therapy for hyperglycemia-related disorders.

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Authors

Nathan Isaac Dibal
nathandibal@unimaid.edu.ng (Primary Contact)
Zainab Muhammad Goni
Martha Orendu Oche Attah
Umar Imam
Muhammad Abdullahi
Muzammil Bashir
Usman Adam
Fatima Aisami
Mohammed Shuwa
Sunday Joseph Manye
Madu Nom Gadzama
Musa Samaila Chiroma
Helga Bedan Ishaya
Author Biographies

Nathan Isaac Dibal, University of Maiduguri

Department of Human Anatomy, University of Maiduguri, Maiduguri, Borno, Nigeria

Zainab Muhammad Goni, University of Maiduguri

Department of Human Anatomy, University of Maiduguri, Maiduguri, Borno, Nigeria

Martha Orendu Oche Attah, Cyprus International University

Department of Medicine, Cyprus International University, North Nicosia, Northern Cyprus, Cyprus

Umar Imam, University of Maiduguri

Department of Human Anatomy, University of Maiduguri, Maiduguri, Borno, Nigeria

Muhammad Abdullahi, University of Maiduguri

Department of Human Anatomy, University of Maiduguri, Maiduguri, Borno, Nigeria

Muzammil Bashir, University of Maiduguri

Department of Human Anatomy, University of Maiduguri, Maiduguri, Borno, Nigeria

Usman Adam, University of Maiduguri

Department of Human Anatomy, University of Maiduguri, Maiduguri, Borno, Nigeria

Fatima Aisami, University of Maiduguri

Department of Human Anatomy, University of Maiduguri, Maiduguri, Borno, Nigeria

Mohammed Shuwa, University of Maiduguri

Department of Human Anatomy, University of Maiduguri, Maiduguri, Borno, Nigeria

Sunday Joseph Manye, University of Maiduguri

Department of Human Anatomy, University of Maiduguri, Maiduguri, Borno, Nigeria

Madu Nom Gadzama, University of Maiduguri

Department of Human Anatomy, University of Maiduguri, Maiduguri, Borno, Nigeria

Musa Samaila Chiroma, Newcastle University Medicine Malaysia

Department of Human Anatomy, Newcastle University Medicine Malaysia, Iskandar Puteri, Johor, Malaysia

Helga Bedan Ishaya, University of Maiduguri

Department of Human Anatomy, University of Maiduguri, Maiduguri, Borno, Nigeria

1.
Dibal NI, Goni ZM, Attah MOO, Imam U, Abdullahi M, Bashir M, Adam U, Aisami F, Shuwa M, Manye SJ, Gadzama MN, Chiroma MS, Ishaya HB. Aloe vera Gel Ameliorates Fat-Rich and High Fructose (FRHF) Diet-Induced Pancreatic and Splenic Damage in Mice. Borneo J Pharm [Internet]. 2023Aug.30 [cited 2024Jun.19];6(3):222-8. Available from: https://journal.umpr.ac.id/index.php/bjop/article/view/5351

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