Structure Modification of Cinnamic Acid to (E)-1-(3,4-dihydroisoquinoline-2(1H)-yl)-3-phenylprop-2-en-1-one and Antioxidant Activity Test by DPPH Method

Dian Agung Pangaribowo (1) , Fathunnisa Fathunnisa (2) , Ari Satia Nugraha (3) , Ayik Rosita Puspaningtyas (4) , Indah Purnama Sary (5)
(1) Universitas Jember , Indonesia
(2) Universitas Jember , Indonesia
(3) Universitas Jember , Indonesia
(4) Universitas Jember , Indonesia
(5) Universitas Jember , Indonesia

Abstract

Antioxidants can protect cells from free radical damage by stabilizing them. One of the compounds that has antioxidant activity is cinnamic acid. Cinnamic acid and its derivatives have several activities: antibacterial, anticancer, and antioxidant. However, the ability of cinnamic acid to capture free radicals is still relatively low. One of the efforts that can be made to increase the antioxidant activity of cinnamic acid is to modify its structure. Structure modification is an effort to improve the pharmacological activity of a compound through chemical synthesis reactions. The cinnamic acid structure can be modified by changing the carboxylic -OH group into an amine group through an N-atom acylation reaction. This study was conducted by reacting cinnamoyl chloride (1a), which is a cinnamic acid derivative with 1,2,3,4-tetrahydroisoquinoline (2b) which is a compound of isoquinoline group to produce (E)-1-(3,4-dihydroisoquinoline-2(1H)-yl)-3-phenylprop-2-en-1-one (3b) and then tested for antioxidant activity using DPPH method. The resulting product compound was yellow crystals with a yield of 81.56%. The antioxidant activity produced by the product is more significant than that of cinnamic acid compounds at the same concentration.

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References

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Authors

Dian Agung Pangaribowo
agung.farmasi@unej.ac.id (Primary Contact)
Fathunnisa Fathunnisa
Ari Satia Nugraha
Ayik Rosita Puspaningtyas
Indah Purnama Sary
Author Biographies

Dian Agung Pangaribowo, Universitas Jember

Department of Pharmacy, Universitas Jember, Jember, East Java, Indonesia

Fathunnisa Fathunnisa, Universitas Jember

Department of Pharmacy, Universitas Jember, Jember, East Java, Indonesia

Ari Satia Nugraha, Universitas Jember

Department of Pharmacy, Universitas Jember, Jember, East Java, Indonesia

Ayik Rosita Puspaningtyas, Universitas Jember

Department of Pharmacy, Universitas Jember, Jember, East Java, Indonesia

Indah Purnama Sary, Universitas Jember

Department of Pharmacy, Universitas Jember, Jember, East Java, Indonesia

1.
Pangaribowo DA, Fathunnisa F, Nugraha AS, Puspaningtyas AR, Sary IP. Structure Modification of Cinnamic Acid to (E)-1-(3,4-dihydroisoquinoline-2(1H)-yl)-3-phenylprop-2-en-1-one and Antioxidant Activity Test by DPPH Method. Borneo J Pharm [Internet]. 2024Aug.30 [cited 2024Dec.14];7(3):254-63. Available from: https://journal.umpr.ac.id/index.php/bjop/article/view/6163

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