Effects of Switching Dose, Dose Variation, and Warfarin Interaction on the Incidence of Stroke Recurrence in Stroke Patients with Atrial Fibrillation

Lailla Affianti Fauzi (1) , Erna Kristin (2) , Rizaldy Taslim Pinzon (3) , Bernadeta Margareta Wara Kushartanti (4) , Novita Intan Arovah (5)
(1) Yogyakarta State University , Indonesia
(2) Universitas Gadjah Mada , Indonesia
(3) Duta Wacana Christian University , Indonesia
(4) Yogyakarta State University , Indonesia
(5) Yogyakarta State University , Indonesia

Abstract

Atrial fibrillation (AF) significantly increases the risk of stroke, necessitating anticoagulation therapy. Warfarin, a commonly prescribed anticoagulant regimen, requires careful monitoring to ensure patient safety. This study aimed to assess the impact of dose switching, dose variation, and potential interactions with warfarin on the incidence of stroke recurrence in stroke patients with AF. The study retrospectively analyzed the treatment records of stroke patients with AF in outpatient settings over one year. The subjects comprised 314 patients who received warfarin prescriptions at two Indonesian Hospitals from January 1, 2015, to December 31, 2019. Out of these patients, 50 had recorded data regarding dose adjustments, variations, and interactions. They were divided into two groups: a case group (n=11) with stroke recurrence and a control group (n=39) without recurrence. Statistical analysis, including chi-square tests and odds ratio calculations, revealed that both warfarin dose switching (OR=7.6) and dose variation (OR=6.6) significantly influenced the incidence of stroke recurrence. It implies that inconsistencies or alterations in warfarin dosing substantially elevate the likelihood of experiencing another stroke, potentially due to inadequate anticoagulation leading to clot formation. Interestingly, the analysis of drug interactions did not significantly impact stroke recurrence. In summary, the recurrence of stroke in patients with AF is notably influenced by warfarin dose adjustments and variations rather than drug interactions. This study highlights the critical importance of precise dosing strategies and vigilant monitoring to enhance the efficacy of anticoagulant therapy in this high-risk population.

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Authors

Lailla Affianti Fauzi
laillaaffianti@uny.ac.id (Primary Contact)
Erna Kristin
Rizaldy Taslim Pinzon
Bernadeta Margareta Wara Kushartanti
Novita Intan Arovah
Author Biographies

Lailla Affianti Fauzi, Yogyakarta State University

Department of Traditional Medicine, Universitas Negeri Yogyakarta, Sleman, Special Region of Yogyakarta, Indonesia

Erna Kristin, Universitas Gadjah Mada

Department of Biomedicine, Universitas Gadjah Mada, Sleman, Special Region of Yogyakarta, Indonesia

Rizaldy Taslim Pinzon, Duta Wacana Christian University

Department of Medicine, Universitas Kristen Duta Wacana, Yogyakarta, Special Region of Yogyakarta, Indonesia

Bernadeta Margareta Wara Kushartanti, Yogyakarta State University

Department of Sports Science, Universitas Negeri Yogyakarta, Sleman, Special Region of Yogyakarta, Indonesia

Novita Intan Arovah, Yogyakarta State University

Department of Medicine, Universitas Negeri Yogyakarta, Sleman, Special Region of Yogyakarta, Indonesia

1.
Fauzi LA, Kristin E, Pinzon RT, Kushartanti BMW, Arovah NI. Effects of Switching Dose, Dose Variation, and Warfarin Interaction on the Incidence of Stroke Recurrence in Stroke Patients with Atrial Fibrillation. Borneo J Pharm [Internet]. 2024Aug.30 [cited 2024Dec.5];7(3):315-23. Available from: https://journal.umpr.ac.id/index.php/bjop/article/view/6603

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