Antidiabetic and TNF-α Lowering Effect of Tagetes erecta Extract in Alloxan-Induced Diabetic Rats

Kadeq Novita Prajawanti (1) , Yohanes Ardian Kapri Negara (2) , Intan Febiola Arianing (3) , Fitri Junitasari (4)
(1) Universitas Anwar Medika , Indonesia
(2) Universitas Anwar Medika , Indonesia
(3) Universitas Anwar Medika , Indonesia
(4) Universitas Anwar Medika , Indonesia

Abstract

Diabetes mellitus is a chronic metabolic disorder characterized by impaired insulin production or action, often leading to pancreatic β-cell dysfunction and apoptosis. Pro-inflammatory cytokines, notably Tumor Necrosis Factor-alpha (TNF-α), play a critical role in the pathogenesis of type 2 diabetes (T2D). While Tagetes erecta (marigold) has demonstrated potential in lowering blood glucose in hyperglycemic conditions, its anti-inflammatory effects in diabetic models remain underexplored. This study aimed to evaluate the antidiabetic and TNF-α lowering effects of T. erecta extract in alloxan-induced diabetic rats. Twenty-five male Wistar rats were divided into a normal control group (n=5) and a diabetic group (n=20) induced by alloxan (blood glucose ≥126 mg/dL). Diabetic rats were then randomized into four treatment subgroups (n=5 each): untreated diabetic control, and diabetic groups treated with T. erecta extract at doses of 25 mg/kg BW, 50 mg/kg BW, or 75 mg/kg BW (administered intraperitoneally). Statistical analysis revealed that T. erecta extract significantly reduced blood glucose levels in alloxan-induced diabetic rats (p <0.05). Furthermore, the highest dose of T. erecta extract (75 mg/kg BW) effectively attenuated elevated TNF-α levels, demonstrating a significant anti-inflammatory effect. In conclusion, this study provides compelling evidence that T. erecta extract exhibits both antidiabetic and anti-inflammatory properties by significantly lowering blood glucose and TNF-α levels in alloxan-induced diabetic rats, particularly at the 75 mg/kg BW dose.

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Authors

Kadeq Novita Prajawanti
kadeq.novita@uam.ac.id (Primary Contact)
Fitri Junitasari
Author Biographies

Kadeq Novita Prajawanti, Universitas Anwar Medika

Department of Medical Laboratory Technology, Universitas Anwar Medika, Sidoarjo, East Java, Indonesia

Yohanes Ardian Kapri Negara, Universitas Anwar Medika

Department of Medical Laboratory Technology, Universitas Anwar Medika, Sidoarjo, East Java, Indonesia

Intan Febiola Arianing, Universitas Anwar Medika

Department of Medical Laboratory Technology, Universitas Anwar Medika, Sidoarjo, East Java, Indonesia

Fitri Junitasari, Universitas Anwar Medika

Department of Medical Laboratory Technology, Universitas Anwar Medika, Sidoarjo, East Java, Indonesia

1.
Prajawanti KN, Negara YAK, Arianing IF, Junitasari F. Antidiabetic and TNF-α Lowering Effect of Tagetes erecta Extract in Alloxan-Induced Diabetic Rats. Borneo J Pharm [Internet]. 2025May30 [cited 2025Jul.29];8(2):184-93. Available from: https://journal.umpr.ac.id/index.php/bjop/article/view/6871

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