Optimasi Formulasi Tablet Lepas Lambat Ekstrak Seledri (Apium graveolens L.) Menggunakan Polimer Xanthan Gum dan Lubrikan Magnesium Stearat dengan Metode Simplex Lattice Design (SLD)
Optimization of Celery Extract (Apium graveolens L.) Sustained Release Tablet Formulation Using Xanthan Gum Polymer and Magnesium Stearate Lubricant with Simplex Lattice Design (SLD) Method
DOI:
https://doi.org/10.33084/jsm.v9i1.5165Keywords:
Celery extract (Apium graveolens L.), Magnesium stearat, Tablet lepas lambat, Xanthan gumAbstract
Antihypertensive drugs undergo first-pass metabolism and therefore have low oral bioavailability. It causes an increase in the frequency of drug use and concentration fluctuations that affect patient comfort. The sustained release tablet formulation was chosen because it can deliver the active substance with good bioavailability. An active antihypertensive substance that can be used is celery extract because it contains flavonoids, so a sustained release tablet formulation was made using xanthan gum and magnesium stearate to produce a constant and controlled release rate. This study aims to knowing the results of celery extract sustained release tablet evaluation using different concentrations of xanthan gum and magnesium stearate, and also obtains the optimal formulation. The manufacture of tablets uses the direct compression method. Powder evaluations include flow property through a funnel, angle of repose, compressibility index, and moisture content. Tablet evaluations include organoleptic, weight uniformity, size uniformity, hardness, friability, disintegration time, and dissolution tests. The evaluation results data were analyzed using Simplex Lattice Design. The powder evaluation result of all formulations meets the requirements of flow property through a funnel, angle of repose, compressibility index, and moisture content. Physical evaluation of the tablets shows all formulations meet the requirement of weight uniformity, hardness, and friability tests. On the size uniformity test, all formulations do not meet the requirement. The disintegration time test results show that F1 does not meet the requirement. Meanwhile, the dissolution test results show that F4 is the best formula because it shows constant and controlled release rate. Based on analyzed using Simplex Lattice Design, the F4 is the most optimal formula with xanthan gum 52 mg and magnesium stearate 3 mg.
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Apriyanto, Bayu Heris, Rolan Rusli, and Agung Rahmadani. 2017. Evaluasi Pati Umbi Talas (Colocasia Esculenta schott) Sebagai Bahan Pengisi Pada Sediaan Tablet Paracetamol. Proceeding of the 5 Th Mulawarman Pharmaceuticals Conferences (April):23–24.
Dhanalakshmi, Siramsetti, and Srinivasa Rao Baratam. 2018. Design and Evaluation of Zolpidem Tartrate Matrix Tablets for Extended Release Using Natural Gums and HPMC K100M. Journal of Applied Pharmaceutical Science 8(7):72–77. doi: 10.7324/JAPS.2018.8712.
Fudholi, Achmad. 2013. Disolusi dan Pelepasan Obat In Vitro. 1st ed. edited by Marjeck and Dimaswids. Yogyakarta: Pustaka Pelajar.
Garg, Ayush, and Amul Mishra. 2022. Formulation and Evaluation of Indapamide Hemihydrate Sustained Release Tablets. Asian Pacific Journal of Health Sciences 9(1):30–36. doi: 10.21276/apjhs.2022.9.1.08.
Gaware, Ravi U., Sujit T. Tambe, Shankar M. Dhobale, and Suresh L. Jadhav. 2019. Formulation and In-Vitro Evaluation of Theophylline Sustained Release Tablet. Journal of Drug Delivery and Therapeutics 9(1-s):48–51. doi: 10.22270/jddt.v9i1-s.2252.
Gunda, Raghavendra Kumar, and A. Vijayalakshmi. 2018. Design, Formulation, and in Vitro Evaluation of Sustained Release Tablets for Losartan Potassium. Vol. 10.
Hadisoewignyo, Lannie, and Achmad Fudholi. 2019. Sediaan Solida. Yogyakarta: Pustaka Belajar.
Hati, Melati Permata, Yandi Syukri, and Bambang Hernawan Nugroho. 2022. Pengaruh Kombinasi Matriks Terhadap Karakter Tablet Metformin HCl Lepas Lambat Sistem Floating Effervescent. 7(2):89–95.
Inayah, Siti, Lizma Febrina, Novita Eka, Kartab Putri, Jaka Fadraersada, Fakultas Farmasi, and Universitas Mulawarman. 2018. Formulasi Dan Evaluasi Sediaan Patch Bukal Mukoadhesif Celecoxib. (November):20–21.
Indartantri, Khusnul Berty, Noval, and Husda Oktaviannor. 2021. Formulation and Evaluation of Floating System Tablet Diphenhydramine HCl Using A Combination of Matrix HPMC K4M and Na. CMC. Jurnal Surya Medika (JSM) 7. doi: 10.33084/jsm.vxix.xxx.
Krisma, Octavia, T. N. Saifullah Sulaiman, and Ilham Kuncahyo. 2015. Optimasi Formula Tablet Lepas Lambat Mucoadhesive Nifedipin dengan Carbopol 940 dan HPMC K15M Sebagai Matriks Secara Simplex Lattice Design. Jurnal Farmasi Indonesia 12(1):7–14.
Kumar, Rakesh, Pankaj Kumar Bhatt, and Saurabh Sharma. 2020. Formulation and Evaluation of Diclofenac Sustained Release Tablets. (August). doi: 10.20959/wjpps20203-15647.
Kusnadi, and Egie Triana Devi. 2017. Isolasi dan Identifikasi Senyewa Flavanoid Pada Ekstrak Daun Seledri (Apium graveolens L.) dengan Metode Refluks. Pancasakti Science Education Journal 2(1):56–67.
Lynatra, Cessa, Wardiyah Wardiyah, and Yetri Elisya. 2018. Formulation of Effervescent Tablet of Temulawak Extract (Curcuma xanthorrhiza roxb.) with Variation of Stevia as Sweetener. SANITAS : Jurnal Teknologi Dan Seni Kesehatan 9(2):72–82. doi: 10.36525/sanitas.2018.9.
Masum, M., M. A. R. Ripon, D. R. Bhowmik, M. T. Amin, S. Arefin, and M. S. Hossain. 2020. Formulation, Development and Evaluation of Bisoprolol Sustained Release Tablets. Journal of Scientific Research 13(1):209–19. doi: 10.3329/jsr.v13i1.47324.
Murtini, Gloria, and Yetri Elisa. 2018. Teknologi Sediaan Solid. Kementrian Kesehatan Republik Indonesia.
Nessa, Sanubari Rela Tobat, M. Mukhtar Husni, and Sufi Auliya Muztika. 2018. Uji Efek Antihipertensi Ekstrak Etanol Daun Seledri (Apium graveolens L.) Pada Tikus Putih Jantan Diinduksi Prednison dan NaCl. Jurnal Akademi Farmasi Prayoga.
Niaz, Sultan, Syed Baqir Shyum Naqvi, Muhammad Arif Asghar, Nazish Mumtaz, and Sheikh Abdul Khaliq. 2018. Formulation and Evaluation of Sustained Release Matrix Tablets of Furosemide Using Different Polymers. 144–51.
Noorjannah, and Noval. 2020. Uji Disolusi Terbanding Antara Sediaan Tablet Ramipril Generik dan Bermerek. Vol. 1. Banjarmasin: Artikel Ilmiah.
Noval, N., & Malahayati, S. 2021. TEKNOLOGI PENGHANTARAN OBAT TERKENDALI.
Noval. 2021. Formulasi Dan Teknologi Sediaan Solida. edited by R. Fitria. Banjarmasin: Penerbit Mitra Cendekia Media.
Pawar, Simran, Malpure Prashant, Surana Santosh, and Bhadane Jayashri. 2019. Formulation and Evaluation of Sustained Release Matrix Tablets of Glibenclamide. International Journal of Pharmacy and Technology 6(2):6572–86.
PERHI. 2019. Konsesus Penatalaksanaan Hipertensi 2019. edited by A. Anna Lukito, E. Harmeiwaty, and M. N. Hustrini. Jakarta.
Pramesti, Ni Kadek Ayu, I. Putu Mas Arie Pradina Putri, Ni Putu Mas Arya Shinta, and I. Gusti Ngurah Jemmy Anton Prasetya. 2021. Polimer-Polimer Untuk Patch Transdermal Yang Mengandung Ekstrak Etanol Daun Seledri (Apium graveolens) Berkhasiat Antihipertensi. BIMFI 8(1):71–79.
Putri, Aristha Novyra, and Dyera Forestryana. 2017. Formulasi dan Karakterisasi Fisik Tablet Floating Mukoadhesif Ranitidin HCl. 04(02):176–86.
Roohullah, Zafar Iqbal, Abdul Baseer, Fazle Rabbi, Abdur Rahim, Muhammad Salman, Sajid Khan Sadozai, and Saeed Ahmad Khan. 2021. In Vitro and In Vivo Evaluation of Carbamazepine Sustained Release Tablets. Transylvanian Review (January 2022).
Rowe, Raymond C., Paul J Sheskey, and E Quinn Marian. 2009. Handbook of Pharmaceutical Excipients. 6th ed. An Imprint of RPS Publishing.
Rustiani, Erni, Mira Miranti, and Alciee Santika Susanti. 2019. Sediaan Tablet Kombinasi Ekstrak Daun Salam (Eugenia polyantha) dan Herba Seledri (Apium graveolens) dengan Variasi Jenis Pengikat. FITOFARMAKA: Jurnal Ilmiah Farmasi 9(2):86–95. doi: 10.33751/jf.v9i2.1608.
Sahu, Sonal, Rohit Dangi, Rohit Patidar, Jagdish Rathi, and Vivek Asati. 2019. Journal of Drug Delivery and Therapeutics Formulation and Evaluation of Sustain Released Matrix Tablet of Atenolol. 9(1):183–89.
Santosa, Dadang Mulya, and Florentia Dian Pertiwi. 2020. Formulasi dan Uji Disolusi Terbanding Tablet Lepas Lambat Natrium Diklofenak Menggunakan Methocel K100M Sebagai Matriks. Indonesia Natural Research Pharmaceutical Journal 5(2):1–11.
Siregar, Charles J. P. 2019. Teknologi Farmasi Sediaan Tablet: Dasar-Dasar Praktis. edited by J. Manurung, A. H. Hadinata, and D. Letare Purba. Penerbit Buku Kedokteran EGC.
Syahrina, Dahlia, and Noval. 2021. Optimasi Kombinasi Asam Sitrat dan Asam Tartrat Sebagai Zat Pengasam Pada Tablet Effervescent Ekstrak Ubi Jalar Ungu (Ipomoea batatas L). Jurnal Surya Medika (JSM) 7(1):156–72. doi: 10.33084/jsm.vxix.xxx.
Triyanto, Dike Agus, Vitis Vini, and Fera Ratna. 2018. Sustained Release of Captopril Tablet with Floating System Using a Cross-Linked Matrix of Alginate. 6(1):11–20. doi: 10.26874/kjif.v6i1.123.
Venkatesh, D. Nagasamy, S. N. Meyyanathan, A. Mohamed Sheik Tharik, and Srinivas Rao. 2020. Formulation and Evaluation of Sustained Release Tablets of Ramipril Formulation and Evaluation of Sustained Release Tablets of Ramipril. (August). doi: 10.5958/0974-360X.2020.00685.X.
Yahya, Idzni Rusydina El, and Marline Abdassah. 2019. Review : Matriks Polimer yang Digunakan Pada Tablet Sustained Release. Farmasetika.Com (Online) 4(3):78. doi: 10.24198/farmasetika.v4i3.22961.
Yanuar, Rizqi Fitria, T. N. Saifullah Sulaiman, and Ilham Kuncahyo. 2015. Optimasi Formulasi Tablet Sustained-Release Nifedipin Kombinasi Natrium Alginat dan HPMC K15M Sebagai Matriks Mukoadhesif Secara Simplex Lattice. Majalah Farmaseutik 11(3):353–61.
Yulianti, Dimas Ayu, and Suyatno Sutoyo. 2021. Formulasi Tablet Effervescent Ekstrak Daun Katuk (Sauropus androgynous L. Merr.) Dengan Variasi Konsentrasi Asam dan Basa. Pharmacy Science and Practice 8(1):34–40.
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