Phytochemical Analysis and Anti-Inflammatory Activity of The Combination of Trigona apicalis propolis Extract and Honey

Paula Mariana Kustiawan (1) , Chaerul Fadly Mochtar Luthfi M (2) , Sinta Ratna Dewi (3) , Jati Pratiwi (4) , Novia Misnawati Aisyiyah (5) , Alfin Syahrian Dwi Nugraha (6) , Irfan Muris Setiawan (7)
(1) Universitas Muhammadiyah Kalimantan Timur , Indonesia
(2) Universitas Muhammadiyah Kalimantan Timur , Indonesia
(3) Universitas Muhammadiyah Kalimantan Timur , Indonesia
(4) Universitas Muhammadiyah Kalimantan Timur , Indonesia
(5) Universitas Muhammadiyah Kalimantan Timur , Indonesia
(6) Universitas Muhammadiyah Kalimantan Timur , Indonesia
(7) Universitas Gadjah Mada , Indonesia

Abstract

Chronic inflammation is common in infectious diseases, rheumatoid arthritis, gout, and autoimmune diseases. However, using non-steroidal anti-inflammatory drugs (NSAIDs) is accompanied by dangerous side effects. Therefore, searching for safer alternative therapies without side effects is very important. A natural blend of ingredients produced by stingless bees from plants was potential as a remedy. Meanwhile, the potential of kelulut bee products from East Kalimantan as an anti-inflammatory is still unknown. This study aimed to compare the chemical composition of kelulut bee (Trigona apicalis) products and evaluate the anti-inflammatory effect of honey, propolis, and their combination. Propolis extract and honey were determined as secondary metabolites. An anti-inflammatory in vivo assay triggered the edema using carrageenan on male mice and measured its anti-inflammatory power value. Propolis extract and honey from T. apicalis have a promising anti-inflammatory effect and are significantly higher than the positive control. Meanwhile, combining propolis extract and honey did not enhance the anti-inflammatory effect. In addition, combining honey and propolis preparations with a ratio of 75 : 25 has a better effect on reducing edema volume than the other two combinations. Still, it is not better than the treatment with propolis extract or honey alone. The content of polyphenol compounds found in honey and propolis preparations is thought to have an important role in reducing edema volume.

Full text article

Generated from XML file

References

Read More

Authors

Paula Mariana Kustiawan
pmk195@umkt.ac.id (Primary Contact)
Sinta Ratna Dewi
Jati Pratiwi
Novia Misnawati Aisyiyah
Alfin Syahrian Dwi Nugraha
Irfan Muris Setiawan
Author Biographies

Paula Mariana Kustiawan, Universitas Muhammadiyah Kalimantan Timur

Department of Pharmacy, Universitas Muhammadiyah Kalimantan Timur, Samarinda, East Kalimantan, Indonesia

Chaerul Fadly Mochtar Luthfi M, Universitas Muhammadiyah Kalimantan Timur

Department of Pharmacy, Universitas Muhammadiyah Kalimantan Timur, Samarinda, East Kalimantan, Indonesia

Sinta Ratna Dewi, Universitas Muhammadiyah Kalimantan Timur

Department of Pharmacy, Universitas Muhammadiyah Kalimantan Timur, Samarinda, East Kalimantan, Indonesia

Jati Pratiwi, Universitas Muhammadiyah Kalimantan Timur

Undergraduate Program of Pharmacy, Universitas Muhammadiyah Kalimantan Timur, Samarinda, East Kalimantan, Indonesia

Novia Misnawati Aisyiyah, Universitas Muhammadiyah Kalimantan Timur

Undergraduate Program of Pharmacy, Universitas Muhammadiyah Kalimantan Timur, Samarinda, East Kalimantan, Indonesia

Alfin Syahrian Dwi Nugraha, Universitas Muhammadiyah Kalimantan Timur

Undergraduate Program of Pharmacy, Universitas Muhammadiyah Kalimantan Timur, Samarinda, East Kalimantan, Indonesia

Irfan Muris Setiawan, Universitas Gadjah Mada

Department of Pharmacy, Universitas Gadjah Mada, Sleman, Special Region of Yogyakarta, Indonesia

1.
Kustiawan PM, Luthfi M CFM, Dewi SR, Pratiwi J, Aisyiyah NM, Nugraha ASD, Setiawan IM. Phytochemical Analysis and Anti-Inflammatory Activity of The Combination of Trigona apicalis propolis Extract and Honey. Borneo J Pharm [Internet]. 2023May31 [cited 2025Feb.28];6(2):125-32. Available from: https://journal.umpr.ac.id/index.php/bjop/article/view/4696

Article Details