Formulasi dan Evaluasi Floating System Tablet Difenhidramin HCl Menggunakan Kombinasi Matriks HPMC K4M dan Na. CMC
Formulation and Evaluation of Floating System Tablet Diphenhydramine HCl Using A Combination of Matrix HPMC K4M and Na. CMC
DOI:
https://doi.org/10.33084/jsm.v7i1.2634Keywords:
Knowledge, Interests, BandagesAbstract
A floating system tablet was made using HPMC K4M and Na matrices. CMC with the active substance diphenhydramine HCl, which absorption in the stomach. The research aims to determine the effect of a combination of HPMC K4M and Na. CMC matrices are optimal in a floating system formulation. This research used an experimental method with a RAL design. Tablets were made by direct compression and were evaluated. The results were then analyzed statistically using One Way ANOVA. The loss results on the drying test, the tapped density test, and the measurement of the angle of repose of all formulations met the requirements. The powder flow rates of all formulations did not meet the requirements. The resulting tablet is white, bitter, round, and smells of medicine. Tablets in all formulations have uniform weight according to requirements. The hardness test results showed that only formulation 3 met the requirements, while all formulations did not meet the requirements in the friability test. In the lag time test, the results obtained in formulation 1 and formulation 2, formulation 3, and formulation 4 are 4 seconds, 4 seconds, 3 seconds, and 1 second. In contrast, the floating time results show that all formulations can float for 24 hours. All evaluation results indicate that the optimal formulation in formulation 3.
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References
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(2015). Formulation and Evaluation of Cinnarizine Floating Tablet for Improved Formulation and Evaluation of Cinnarizine Floating Tablet for Improved Absorption. 2013(September 2013), 1–5
2. Begum, M. Y., Avanthi, J., Shwetha, A., Madhuri, T., Sudhakar, M., & Naveen, D. (2014). Formulation And Evaluation Of Sustained Release Floating Tablets Of Loratadine. International Journal of Pharmaceutical Sciences And Research, 5(10), 4375–4385. https://doi.org/10.1017/CBO9781107415324.004
3. Pubchem. (2019). Diphenhydramine.
4. Alabazi, M. Y., & Elzein, H. (2012). An approach to formulating an oral floating drug delivery system for dexchlorpheniramine maleate using factorial design. Pharmazie, 67(7), 611–617. https://doi.org/10.1691/ph.2012.1137
5. Singh, S., & Pathak, K. (2016). Assessing the biodhesivity of Acconon MC 8-2 EP/NF for gastroretention of floating microsponges of loratadine and achieving controlled drug delivery. Pharmaceutical and Biomedical Research, 2(2), 58–74. https://doi.org/10.18869/acadpub.pbr.2.2.9
6. Fouladi, F., & Mortazavi, S. A. (2012). Preparation and in-vitro evaluation of gastroretentive bupropion hydrochloride tablets. Tropical Journal of Pharmaceutical Research, 11(3), 351–359. https://doi.org/10.4314/tjpr.v11i3.3
7. Pradana, A. T., Parfati, N., & Shira, S. A. (2015). Formulasi Floating Tablet Menggunakan Variasi Konsentrasi HPMC K100M Terhadap Kemampuan Mengapung Dan Profil Disolusi Tablet Ranitidine HCl. Jurnal Ilmiah Sains & Teknologi, 9(1), 11–21.
8. Hadisoewignyo, L., & Achmad, F. (2016). Sediaan Solida Edisi Revisi. Pustaka Pelajar.Care and Sciences, 1(1), 45-54.
9. Noval, N., Appriliani, R., & Oktaviannoor, H. (2021). Evaluasi Pengaruh Konsentrasi Pati Biji Cempedak (Artocarpus champeden) sebagai Bahan Pengisi pada Formulasi Tablet Paracetamol. Jurnal Surya Medika (JSM), 6(2), 111-118. https://doi.org/10.33084/jsm.v6i2.2127.
10. Irfan, M., Akram, A., Zahoor, A. F., Qadir, M. I., Hussain, A., Abbas, N., Khan, A., Arshad, M. S., & Khan, N. I. (2016). Formulation parameters affecting floating behaviour and drug release from extended release floating tablets of ranitidine hydrochloride. Latin American Journal of Pharmacy, 35, 1206–1216.
11. Putri, A. N., & Forestryana, D. (2017). Formulasi dan Karakterisasi Fisik Tablet Floating Mukoadhesif Ranitidin HCl. Jurnal Pharmascience, 4(2), 176–186. https://doi.org/10.20527/jps.v4i2.5771
12. Noorjannah, N., & Noval, N. (2020). Uji Disolusi Terbanding Antara Sediaan Tablet Ramipril Generik Dan Bermerek. Journal of Pharmaceutical
13. Fitriani, L., Abdillah, R., & Ben, E. S. (2017). Formulation of Metformin HCl Floating Tablet using HPC , HPMC K100M , and the Combinations. 4(2), 79–82. https://doi.org/10.29208/jsfk.2017.4.1.201
14. Murtini, G., & Elisa, Y. (2018). Bahan Ajar Farmasi Teknologi Sediaan Solid. In Kementrian Kesehatan Republik Indonesia (Pertama). Kementrian Kesehatan Republik Indonesia. https://doi.org/10.1017/CBO9781107415324.004
15. Fitriana, Y., Sunarni, T., & Priyanto, W. (2010). Pengaruh Bahan Pengikat Gelatin dalam Formula Tablet Ekstrak Daun Kemuning (Murraya paniculata (L.) Jack) secara Granulasi Basah. Jurnal Farmasi Indonesia, 7(2), 67–72.
16. Taufikurrahmi, Kharimah, H., Fatmawati, H. D., Hidayatullah, S., & Chabib, L. (2017). Pengaruh Variasi Bahan Penghancur terhadap Sifat Fisikokimia dan Disolusi Tablet Aminofilin sebagai Terapi Asma. Jurnal Pharmascience, 04(01), 74–84.
17. Dja’far, S., & Satria, F. (2017). Perbandingan Mutu Fisik Tablet Parasetamol Menggunakan Metode Gelatinasi Dan Pragelatinasi Dengan Penambahan Bahan Pengikat Pati Singkong ( Amylum manihot ). Akademi Farmasi Putra Indonesia, 3(1), 1–10.
18. Rori, W. M., Yamlean, P. V., & Sudewi, S. (2016). Formulasi Dan Evaluasi Sediaan Tablet Ekstrak Daun Gedi Hijau (Abelmoschus manihot) Dengan Metode Granulasi Basah. Formulasi Dan Evaluasi Sediaan Tablet Ekstrak Daun Gedi Hijau (Abelmoschus Manihot) Dengan Metode Granulasi
Basah, 5(2), 243–250. https://doi.org/10.2307/j.ctvswx8f2.8
19. Mariyani, K. A., & Setyawan, E. I. (2012). Pengaruh Konsentrasi Amilum Jagung Pregelatinasi sebagai Bahan Penghancur ( Ayu , M ., Pengaruh Konsentrasi Amilum Jagung Pregelatinasi sebagai Bahan Penghancur ( Ayu , M ., Sri , A ., Eka , I . S .). 1(1), 39–49.
20. Kholidah, S., & Khumaidi, A. (2014). Formulasi Tablet Effervescent Jahe (Z Officinale Roscoe) Dengan Variasi Konsentrasi Sumber Asam Dan Basa. Online Jurnal of Natural Science, 3(3), 216–229.
21. Gozali, D., Susilawati, Y., Simorangkir, T. P. H., & Utami, N. F. (2016). Formulasi Tablet Hisap Yang Mengandung Ekstrak Aakar Ginseng Korea ( Panax ginseng C . A . Meyer ) dan Ekstrak Rimpang Temulawak ( Curcuma xanthorrhiza ROXB .) (Vol. 8, Issue 1).
22. Ditjen, P. (1979). Farmakope Indonesia Edisi III (III). Departemen Kesehatan Republik Indonesia.
23. Alabrazi, M., & Elzein, H. (2015). The study of differences between MCC and DCP as a diluent in the evaluation of dexchlorpheniramine maleate floating tablet. International Journal of Pharmaceutical Sciences Review and Research, 31(1), 107–112.
24. Nariswara, Y., Hidayat, N., & Effendi, M. (2013). Pengaruh Waktu Dan Gaya Tekan Terhadap Kekerasan Dan Waktu Larut Tablet Effervescent Dari Serbuk Wortel (Daucus Carota L.). Jurnal Industria, 2(1), 27–35.
25. Fitri, Y. A., Ferdiansyah, R., & Legowo, W. P. (2018). Pengaruh variasi konsentrasi kalium sulfat terhadap karakteristik karagenan dan aplikasinya sebagai pengisi sediaan tablet. Jurnal Farmasi Galenika, 5(2), 56–70.
26. Noval, N., & Rosyifa, R. (2021). Dispersi Padat untuk Peningkatan Laju Disolusi Natrium Diklofenak dengan Variasi Konsentrasi Polivinil Pirolidon K30. Jurnal Surya Medika (JSM), 6(2), 94-101. https://doi.org/10.33084/jsm.v6i2.2125.
27. Dewi, S. T. R., & Karim, D. (2019). Pengaruh Penggunaan Serbuk Umbi Talas (Colocasia esculenta L.Scoot) sebagai Bahan Pengikat Dalam Pembuatan Tablet Parasetamol. Media Farmasi, XVI(1), 1–6.
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Published
2021-08-30
How to Cite
Indartantri, K. B., Noval, N., & Oktaviannoor, H. (2021). Formulasi dan Evaluasi Floating System Tablet Difenhidramin HCl Menggunakan Kombinasi Matriks HPMC K4M dan Na. CMC: Formulation and Evaluation of Floating System Tablet Diphenhydramine HCl Using A Combination of Matrix HPMC K4M and Na. CMC. Jurnal Surya Medika (JSM), 7(1), 107–114. https://doi.org/10.33084/jsm.v7i1.2634
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