Formulasi dan Evaluasi Sediaan Obat Kumur (Mouthwash) dari Ekstrak Etanol Daun Kalangkala (Litsea angulata) sebagai Antiseptik Mulut
Mouthwash Formulation and Evaluation of Kalangkala Leaves (Litsea angulata) Ethanol Extract as a Mouth Antiseptic
DOI:
https://doi.org/10.33084/jsm.v7i1.2662Keywords:
Kalangkala leaves, Mouthwash, Mouth AntisepticAbstract
Research of mouthwash formulation and evaluation of kalangkala leaves extract (Litsea angulata) as an oral antiseptic also has been tested in Streptococcus mutans bacteria by variation in the concentration of extract 2%, 2,5%, and 3%, which aims to determine the ideal formula in physical quality and has the highest antibacterial activity based on an inhibition zone of Streptococcus mutans bacteria in mouthwash formula. The methods used include the step of extraction of Kalangkala leaves, preparation of mouthwash with 3 formula F1 (2%), F2 (2,5%), and F3 (3%) followed by an evaluation that includes organoleptic, pH test, viscosity test, and the test of inhibition zone bacteria. The test of inhibition zone bacteria used NA media with diffusion method. Stability was performed on weeks 1, 2, 3, and 4. The result showed variation in the concentration of extract kalangkala leaves in a mouthwash formula affects the diameter of the inhibition zone. But did not have a significant effect on the physical stability properties of the mouthwash formula. Mouthwash formula has the highest antibacterial activity based on the inhibition zone of Streptococcus mutans that is 3% contained in formula F3.
Downloads
Download data is not yet available.
References
1. Bustomi, E. (2010) Mouthwas Life Style atau Kesehatan? Agustus 13, 2019, http://www.pitoyo.com
2. Kidd, E.A.M and S.J, B. (1994) Dasar-Dasar Karies Penyakit dan Penanggulangannya. Terjemahan. Jakarta: EGC.
3. Roeslan, B. O. (1996) Karakteristik Streptococcus mutans Penyebab Karies gigi. Majalah Il. FKG Usakti.
4. POM, D. (1999) Farmakope Indonesia. IV. Jakarta: Depkes RI.
5. Kurniawati, Darini, Noval Noval, and Kunti Nastiti. 2020. “POTENSI ANTISEPTIK POLIHERBAL DAUN SIRIH (Piper Betle), KULIT JERUK NIPIS (Citrus Aurantifolia) DAN TANAMAN BUNDUNG (Actinuscirpus Grossus) PADA TINDAKAN KEPERAWATAN DAN KEBIDANAN.” Dinamika Kesehatan: Jurnal Kebidanan Dan Keperawatan 11(1): 420–31.
6. Anastasia, A., Yuliet and Tandah, M. R. (2017) „Formulasi Sediaan Mouthwash Pencegah Plak Gigi Ekstrak Biji Kakao ( Theobroma Cacao L ) Dan Uji Efektivitas Pada Bakteri Streptococcus Mutans‟, GALENIKA Journal of Pharmacy, 3(March), pp. 84–92.
7. Noval, N., Nastiti, K., Nugraha, D., Rahmadani, R., & Alawiyah, T. (2020). PRODUK INOVASI HAND SANITIZER DARI AKAR BAJAKAH SEBAGAI UPAYA PENCEGAHAN DI MASA PANDEMI COVID-19. LOGISTA - Jurnal Ilmiah Pengabdian Kepada Masyarakat, 4(2), 305-312. doi:10.25077/logista.4.2.305-312.2020.
8. Noval, N., Appriliani, R., & Oktaviannoor, H. (2021). Evaluasi Pengaruh Konsentrasi Pati Biji Cempedak (Artocarpus champeden) sebagai Bahan Pengisi pada Formulasi Tablet Paracetamol. Jurnal Surya Medika (JSM), 6(2), 111-118. https://doi.org/10.33084/jsm.v6i2.2127.
9. Noval, N., Yuwindry, I., & Syahrina, D. (2019). Phytochemical Screening and Antimicrobial Activity of Bundung Plants Extract by Dilution Method. Jurnal Surya Medika. https://doi.org/10.33084/jsm.v5i1.954.
10. Kuspradini, H. Putri, AS, Diana, R. 2018. Potensi Tumbuhan Genus Litsea. Samarinda: Mulawarman University Press
11. Gelone, S. and Gennaro, A. (2005) „Remingtons The Sciences and Practice of Pharmacy ed 21th‟, Lippincot Williams & Wilkins Philadelpia 1672.
12. Mccullough, M. J. and Farah, C. S. (2008) „The role of alcohol in oral carcinogenesis with particular reference to alcohol-containing mouthwashes‟, Australian Dental Journal, pp. 302–305. doi: 10.1111/j.1834-7819.2008.00070.x.
13. Handayani, F., Warnida, H. and Nur, S. J. (2016) „Formulasi Dan Uji Aktivitas Antibakteri Streptococcus Mutans Dari Sediaan Mouthwash Ekstrak Daun Salam (Syzygium polyanthum (Wight) Walp.)‟, Media Sains, 9(April), pp. 74–84.
14. Noval, N., Nugraha, D. F., Nastiti, K., Syahrina, D., & Novia, N. (2021). Local Natural Product Development in the Era of Covid 19 Pandemic. Indonesia Berdaya, 2(2), 133-140.
15. Haryono, I. A., Noval, N., & Nugraha, B. (2021). Formulasi Buah Tampoi (Baccaurea macrocarpa) dalam Sediaan Masker Gel sebagai Antiaging. Jurnal Surya Medika (JSM), 6(2), 102-110. https://doi.org/10.33084/jsm.v6i2.2126
16. Harliantika, Y. (2021). Formulasi dan Evaluasi Hidrogel Ekstrak Etanol Daun Gaharu (Aquilaria malacensis Lamk.) dengan Kombinasi Basis Karbopol 940 dan HPMC K4M. Journal of Pharmacy and Science, 6(1), 37-46.
17. Retnowati, Yuliana., Bialangi, Nurhayati., Posangi, Nona Wingti. 2011. Pertumbuhan Bakteri Staphylococcus aureus pada Media yang Diekspos dengan Infus Daun Sambiloto (Andrographis paniculata). Saintek Vol.6 No.2.
18. Whitman, H. and Macnair, N. G. (2010) „Finfish and Shelfish Bacteriology Manual‟, in Techniques and Procedures.
19. Sutton, S. (2011) „Determination of Inoculum for Microbilogical Testing‟, Journal of GXP Compliance.
20. Anastasia, Tamara. 2020. Kandungan Povidone-Iodine Dalam Obat Kumur Bisa Cegah Virus Corona, Maksudnya? Oktober 21, 2020. https://www.klikdokter.com/
21. Akarina, W. (2011) „Pengaruh Konsentrasi Humektan terhadap Stabilitas Formula Obat Kumur‟, Jurnal USU Medan.
22. Mardiana, Z. H., Gadri, A. and Mulqie, L. (2015) „Formulasi Gel yang Mengandung Lendir Bekicot (Achatina Fulica) serta Uji Aktivitas Antibakteri terhadap Propionibacterium Acnes [PROSIDING]‟, Prosiding Penelitian SPeSIA, (2007), pp. 223–230.
23. Lucida, H., Bakhtiar, A. and Putri, A. (2007) „Formulasi Sediaan Antiseptik Mulut dari Katekin Gambir‟, J. Sains Tek. Far., 12(1).
24. Pradewa, M. R. (2008) „Formulasi Sediaan Obat Kumur (Mouthwash) Berbahan Dasar Gambir‟, Bogor ITB.
25. Rowe, R. C., Sheskey, P. J. and Owen, S. C. (2009) Handbook of Pharmaceutical Exipiens. 6th edn. London: American Pharmaceutical Association.
26. Ardana, M., Aeyni, V. and Ibrahim, A. (2015) „Formulasi dan optimasi basis gel hpmc (‟, J. Trop. Pharm. Chem, 3(2), pp. 101–108.
27. Noval, Rosyifa and Annisa (2020) „Effect of HPMC Concentration Variation as Gelling Agent on Physical Stability of Formulation Gel Ethanol Extract Bundung Plants ( Actinuscirpus Grossus )‟. doi: 10.4108/eai.23-11-2019.2298326.
28. Lachman, L. and Lieberman, H. A. (1994) Teori dan Praktek Farmasi Industri. Kedua. Jakarta: UI Press.
29. Martin; et al (1993) Farmasi Fisik. Ketiga. Jakarta: UI Press.
30. Nugraha, L. S. A. (2012) Pengaruh Kadar Na CMC Sebagai Bahan Pengental Terhadap Karakteristik Fisik Losion Repelan Minyak Akar Wangi (Vetiveria zizanioides (L.) Nash).
31. Jawetz (1996) Mikrobiologi Kedokteran. 23rd edn. Jakarta: Buku Kedokteran EKG.
32. Noval, Noval, Melviani Melviani, Novia Novia, and Dahlia Syahrina. 2020. “Formulasi Dan Evaluasi Sediaan Obat Kumur (Mouthwash) Dari Ekstrak Etanol Tanaman Bundung (Actinoscirpus Grossus) Sebagai Antiseptik Mulut”. Jurnal Surya Medika (JSM) 6 (1), 112-20. https://doi.org/10.33084/jsm.v6i1.1626.
33. Martin, A. (2008) Farmasi Fisik Dasar-Dasar Kimia Fisik dalam Ilmu Farmasetik. Jakarta: Universitas Indonesia.
2. Kidd, E.A.M and S.J, B. (1994) Dasar-Dasar Karies Penyakit dan Penanggulangannya. Terjemahan. Jakarta: EGC.
3. Roeslan, B. O. (1996) Karakteristik Streptococcus mutans Penyebab Karies gigi. Majalah Il. FKG Usakti.
4. POM, D. (1999) Farmakope Indonesia. IV. Jakarta: Depkes RI.
5. Kurniawati, Darini, Noval Noval, and Kunti Nastiti. 2020. “POTENSI ANTISEPTIK POLIHERBAL DAUN SIRIH (Piper Betle), KULIT JERUK NIPIS (Citrus Aurantifolia) DAN TANAMAN BUNDUNG (Actinuscirpus Grossus) PADA TINDAKAN KEPERAWATAN DAN KEBIDANAN.” Dinamika Kesehatan: Jurnal Kebidanan Dan Keperawatan 11(1): 420–31.
6. Anastasia, A., Yuliet and Tandah, M. R. (2017) „Formulasi Sediaan Mouthwash Pencegah Plak Gigi Ekstrak Biji Kakao ( Theobroma Cacao L ) Dan Uji Efektivitas Pada Bakteri Streptococcus Mutans‟, GALENIKA Journal of Pharmacy, 3(March), pp. 84–92.
7. Noval, N., Nastiti, K., Nugraha, D., Rahmadani, R., & Alawiyah, T. (2020). PRODUK INOVASI HAND SANITIZER DARI AKAR BAJAKAH SEBAGAI UPAYA PENCEGAHAN DI MASA PANDEMI COVID-19. LOGISTA - Jurnal Ilmiah Pengabdian Kepada Masyarakat, 4(2), 305-312. doi:10.25077/logista.4.2.305-312.2020.
8. Noval, N., Appriliani, R., & Oktaviannoor, H. (2021). Evaluasi Pengaruh Konsentrasi Pati Biji Cempedak (Artocarpus champeden) sebagai Bahan Pengisi pada Formulasi Tablet Paracetamol. Jurnal Surya Medika (JSM), 6(2), 111-118. https://doi.org/10.33084/jsm.v6i2.2127.
9. Noval, N., Yuwindry, I., & Syahrina, D. (2019). Phytochemical Screening and Antimicrobial Activity of Bundung Plants Extract by Dilution Method. Jurnal Surya Medika. https://doi.org/10.33084/jsm.v5i1.954.
10. Kuspradini, H. Putri, AS, Diana, R. 2018. Potensi Tumbuhan Genus Litsea. Samarinda: Mulawarman University Press
11. Gelone, S. and Gennaro, A. (2005) „Remingtons The Sciences and Practice of Pharmacy ed 21th‟, Lippincot Williams & Wilkins Philadelpia 1672.
12. Mccullough, M. J. and Farah, C. S. (2008) „The role of alcohol in oral carcinogenesis with particular reference to alcohol-containing mouthwashes‟, Australian Dental Journal, pp. 302–305. doi: 10.1111/j.1834-7819.2008.00070.x.
13. Handayani, F., Warnida, H. and Nur, S. J. (2016) „Formulasi Dan Uji Aktivitas Antibakteri Streptococcus Mutans Dari Sediaan Mouthwash Ekstrak Daun Salam (Syzygium polyanthum (Wight) Walp.)‟, Media Sains, 9(April), pp. 74–84.
14. Noval, N., Nugraha, D. F., Nastiti, K., Syahrina, D., & Novia, N. (2021). Local Natural Product Development in the Era of Covid 19 Pandemic. Indonesia Berdaya, 2(2), 133-140.
15. Haryono, I. A., Noval, N., & Nugraha, B. (2021). Formulasi Buah Tampoi (Baccaurea macrocarpa) dalam Sediaan Masker Gel sebagai Antiaging. Jurnal Surya Medika (JSM), 6(2), 102-110. https://doi.org/10.33084/jsm.v6i2.2126
16. Harliantika, Y. (2021). Formulasi dan Evaluasi Hidrogel Ekstrak Etanol Daun Gaharu (Aquilaria malacensis Lamk.) dengan Kombinasi Basis Karbopol 940 dan HPMC K4M. Journal of Pharmacy and Science, 6(1), 37-46.
17. Retnowati, Yuliana., Bialangi, Nurhayati., Posangi, Nona Wingti. 2011. Pertumbuhan Bakteri Staphylococcus aureus pada Media yang Diekspos dengan Infus Daun Sambiloto (Andrographis paniculata). Saintek Vol.6 No.2.
18. Whitman, H. and Macnair, N. G. (2010) „Finfish and Shelfish Bacteriology Manual‟, in Techniques and Procedures.
19. Sutton, S. (2011) „Determination of Inoculum for Microbilogical Testing‟, Journal of GXP Compliance.
20. Anastasia, Tamara. 2020. Kandungan Povidone-Iodine Dalam Obat Kumur Bisa Cegah Virus Corona, Maksudnya? Oktober 21, 2020. https://www.klikdokter.com/
21. Akarina, W. (2011) „Pengaruh Konsentrasi Humektan terhadap Stabilitas Formula Obat Kumur‟, Jurnal USU Medan.
22. Mardiana, Z. H., Gadri, A. and Mulqie, L. (2015) „Formulasi Gel yang Mengandung Lendir Bekicot (Achatina Fulica) serta Uji Aktivitas Antibakteri terhadap Propionibacterium Acnes [PROSIDING]‟, Prosiding Penelitian SPeSIA, (2007), pp. 223–230.
23. Lucida, H., Bakhtiar, A. and Putri, A. (2007) „Formulasi Sediaan Antiseptik Mulut dari Katekin Gambir‟, J. Sains Tek. Far., 12(1).
24. Pradewa, M. R. (2008) „Formulasi Sediaan Obat Kumur (Mouthwash) Berbahan Dasar Gambir‟, Bogor ITB.
25. Rowe, R. C., Sheskey, P. J. and Owen, S. C. (2009) Handbook of Pharmaceutical Exipiens. 6th edn. London: American Pharmaceutical Association.
26. Ardana, M., Aeyni, V. and Ibrahim, A. (2015) „Formulasi dan optimasi basis gel hpmc (‟, J. Trop. Pharm. Chem, 3(2), pp. 101–108.
27. Noval, Rosyifa and Annisa (2020) „Effect of HPMC Concentration Variation as Gelling Agent on Physical Stability of Formulation Gel Ethanol Extract Bundung Plants ( Actinuscirpus Grossus )‟. doi: 10.4108/eai.23-11-2019.2298326.
28. Lachman, L. and Lieberman, H. A. (1994) Teori dan Praktek Farmasi Industri. Kedua. Jakarta: UI Press.
29. Martin; et al (1993) Farmasi Fisik. Ketiga. Jakarta: UI Press.
30. Nugraha, L. S. A. (2012) Pengaruh Kadar Na CMC Sebagai Bahan Pengental Terhadap Karakteristik Fisik Losion Repelan Minyak Akar Wangi (Vetiveria zizanioides (L.) Nash).
31. Jawetz (1996) Mikrobiologi Kedokteran. 23rd edn. Jakarta: Buku Kedokteran EKG.
32. Noval, Noval, Melviani Melviani, Novia Novia, and Dahlia Syahrina. 2020. “Formulasi Dan Evaluasi Sediaan Obat Kumur (Mouthwash) Dari Ekstrak Etanol Tanaman Bundung (Actinoscirpus Grossus) Sebagai Antiseptik Mulut”. Jurnal Surya Medika (JSM) 6 (1), 112-20. https://doi.org/10.33084/jsm.v6i1.1626.
33. Martin, A. (2008) Farmasi Fisik Dasar-Dasar Kimia Fisik dalam Ilmu Farmasetik. Jakarta: Universitas Indonesia.
Downloads
Published
2021-08-30
How to Cite
Rohama, R., & Melviani, M. (2021). Formulasi dan Evaluasi Sediaan Obat Kumur (Mouthwash) dari Ekstrak Etanol Daun Kalangkala (Litsea angulata) sebagai Antiseptik Mulut: Mouthwash Formulation and Evaluation of Kalangkala Leaves (Litsea angulata) Ethanol Extract as a Mouth Antiseptic. Jurnal Surya Medika (JSM), 7(1), 248–256. https://doi.org/10.33084/jsm.v7i1.2662
Issue
Section
Articles
License
All rights reserved. This publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording.
