Formulasi dan Aktivitas Antibakteri Krim Anti Acne Ekstrak Etanol Bawang Dayak (Eleutherine bulbosa (Mill.) Urb.) terhadap Staphylococcus epidermidis
Formulation and Antibacterial Activity of Anti-acne Cream of Bawang Dayak Ethanol Extract (Eleutherine bulbosa (Mill.) Urb.) against Staphylococcus epidermidis
DOI:
https://doi.org/10.33084/jsm.v7i2.3217Keywords:
Acne, Bawang dayak, Cream, Eleutherine bulbosa, Medicinal plantAbstract
Bawang Dayak is one of the typical plants of Borneo which is efficacious as traditional medicine. Empirically Bawang Dayak knows to have properties for skin diseases such as acne. This study aimed to determine the differences in the physical properties of anti-acne cream of Bawang Dayak (Eleutherine bulbosa (Mill.) Urb.) bulb ethanol extract on day 0 and day 7 and to determine its antibacterial activity against Staphylococcus epidermidis with Disc Diffusion (Kirby-Bauer) method. The cream formulation was made with various concentrations of Bawang Dayak ethanol extract, F1 (5%), F2 (10%), F3 (15%), and F4 (20%). The results showed that F1 cream on day 0 fulfilled all the requirements for homogeneity, pH, adhesion, and dispersive ability. Furthermore, all anti-acne cream formulations of Bawang Dayak bulb ethanol extract had the ability to inhibit the Staphylococcus epidermidis in F1 (5%), F2 (10%), F3 (15%), and F4 (20%) with inhibition zones were 10.4±0.3 mm; 12.9±3.7 mm; 14.9±0.8 mm; and 14.6±0.5 mm on day 0; and inhibition zones were 12.9±1.5 mm; 16.9±1.0 mm; 19.3±1.0 mm; dan 20.3±1.4 mm on day 7, which means there is an increase in inhibitory power on day 7. This study shows the potential of the ethanol extract of Bawang Dayak bulb as an anti-acne cream, but further research is needed to improve the composition and stability of the formulation so that it can be developed as an anti-acne cream product.
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References
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2. Shinde, P., Sapate, R., Shinde, S., Kadam, A., Jadhav, R., Mali, H., & Gidde, N. 2021. Formulation and Optimization of Semi Herbal Anti Acne Compact Face Powder by Allium Sativum and Myristica Fragrans Extract. Indo American Journal of Pharmaceutical Research. 11(4):1642-1649. doi:10.5281/zenodo.4772489
3. Vora, J., Srivastava, A., & Modi, H. 2018. Antibacterial and Antioxidant Strategies for Acne Treatment Through Plant Extracts. Informatics in Medicine Unlocked. 13:128-132. doi:10.1016/j.imu.2017.10.005
4. Zaenglein, A.L., Pathy, A.L., Schlosser, B.J., Alikhan, A., Baldwin, H.E., Berson, D.S., et al. 2016. Guideline of Care for The Management of Acne Vulgaris. Journal of American Academy of Dermatology. 74(5):945-973.e33. doi:10.1016/j.jaad.2015.12.037
5. Syamsul, E.K., Supomo, Wijaya, H., & Nugroho, B.A. 2015. Formulasi Ekstrak Etanol Umbi Bawang Tiwai (Eleutherine americana) dalam Sediaan Krim Anti Acne. Tradisional Medical Journal. 20(3).
6. Novaryatiin, S., & Ardhany, S.D. 2019. The Antibacterial Activity of Bawang Dayak (Eleutherine bulbosa (Mill.) Urb.) from Central Kalimantan Against Acne-Causing Bacteria. Internationa Journal of Applied Pharmaceutics. 11(SI5):22-25. doi:10.22159/ijap.2019.v11s5.T0032
7. Novaryatiin, S., Ramli, A., & Ardhany, S.D. 2019. Uji Daya Hambat Ekstrak Etanol Bawang Dayak (Eleutherine bulbosa (Mill.) Urb.) Terhadap Bakteri Staphylococcus aureus. Jurnal Surya Medika. 4(2):51-59. doi:10.33084/jsm.v4i2.565
8. Novaryatiin, S., Pratiwi, A.M. & Ardhany, S.D. 2018. Uji Daya Hambat Ekstrak Etanol Bawang Dayak (Eleutherine bulbosa (Mill.) Urb.) Terhadap Bakteri Staphylococcus epidermidis. Anterior jurnal. 18(1):92-97. doi:10.33084/anterior.v18i1.392
9. Ardhany, S.D., Puspitasari, Y., Meydawati, Y., & Novaryatiin, S. 2019. Formulasi Sediaan Krim Anti Acne dan Uji Aktivitas Ekstrak Etanol Bawang Dayak (Eleutherine bulbpsa (Mill.) Urb.) Terhadap Propionibacterium acnes. Jurnal Sains dan Kesehatan. 20(2):121-126. doi: 10.25026/jsk.v2i2.136
10. Ardhany, S.D., & Novaryatiin, S. 2019. Antibacterial Activity of Ethanolic Extract Bawang Dayak (Eleutherine bulbosa (Mill.) Urb.) in Cream Against Propionibacterium acnes. Int J App Pharm. 11(SI5):1-4. doi:10.22159/ijap.2019.v11s5.T0020
11. Departemen Kesehatan Republik Indonesia. 1995. Materia Medika Indonesia. Jilid VI. Jakarta.
12. Arifianti, L. Oktarina, R.D., & Kusumawati, I. 2014. Pengaruh Jenis Pelarut Pengekstraksi Terhadap Kadar Sinensetin dalam Ekstrak Daun Orthosiphon stamineus Benth. E-Journal Planta Husada. 2(1):1-4.
13. Nazliniwaty, Arianto, A., & Nasution, K.R.A. 2016. Formulation and Anti-Aging Effect of Cream Containing Breadfruit (Artocarpus altilis (Parkinson) Fosberg) Leaf Extract. International Journal of PharmTech Research. 9(12):524–530.
14. Safitri, F.W., Syahreza, A., Farah, H.S., Satrio, B.M., & Hadi, S.I. 2016. Antioxidant Activities and Antioxidant Cream Formulation of Corn Silk (Zea Mays L) Extract. Sains Medika. 7(2):64–69.
15. Anief, M. 2010. Ilmu Meracik Obat. Yogyakarta: Gajah Mada University Press.
16. Ermawati, D., Chasanah, U., & Dwi, D. 2017. Optimization Formulation on Antioxidant Cream Vitamin E (α-Tocopherol Acetate) with Virgin Coconut Oil (VCO). Advances in Health Science (AHSR). 2:362-366.
17. Ulaen, S.P.J., Banne, Y., & Suatan, R.A. 2012. Pembuatan Salep Anti Jerawat dari Ekstrak Rimpang Temulawak (Curcuma xanthorrhiza Roxb). Jurnal Ilmiah Farmasi. 3(2):45–49.
18. Rachmalia, N., Mukhlishah, I., Sugihartini, N., & Yuwono, T. 2016. Daya Iritasi dan Sifat Fisik Sediaan Salep Minyak Atsiri Bunga Cengkih (Syzigium aromaticum) pada Basis Hidrokarbon. Majalah Farmaseutik. 12: 372–376.
19. Fatmawati, F., Jafar, G., & Riantini, R. 2020. Pengujian Penghambatan Enzim Tirosinase pada Formulasi Masker Pencerah Wajah dari Kombinasi Kefir Susu Sapi dan Rumput Laut (Euchema cottonii). Analit: Analytical and Environmental Chemistry. 5(1):42-52.
20. Putra, R.E.D., Homenta, H. & Wowor, V.N.S. 2017. Uji Daya Hambat Perasan Jeruk Purut Citru hytrix Terhadap Bakteri Staphylococcus epidermidis in Vitro. Pharmacon. 6(1): 65-66.
21. Shahbazi, Y. 2017 Antibacterial and Antioxidant Properties of Methanolic Extracts of Apple (Malus pumila), Grape (Vitis vinifera), Pomegranate (Punica granatum L.), and Common Fig (Ficus carica L.) Fruits. Pharmaceutical Sciences. 24(4):308–315. doi:10.15171/PS.2017.45
22. Dewi, A.P., & Mardhiyani, D. 2021. Formulation and Antibacterial Activity of Liquid Soap Containing Ketapang (Terminalia catappa L.) Leaves Extract. Borneo Journal of Pharmacy. 4(1):43-50. doi:10.33084/bjop.v4i1.1589
23. Ouchari, L., Boukeskasse, A., Bouizgarne, B., & Ouhdouch, Y. 2019. Antimicrobial Potential of Actinomycetes Isolated from The Unexplored Hot Merzouga Desert and Their Taxonomic Diversity. Biology Open. 8:1-7. doi:10.1242/bio.035410
24. Pratama, M.R.F., & Aziz, I.R. 2019. Molecular Docking of Bawang Dayak (Eleutherine bulbosa) Secondary Metabolites as Bacterial Cell Wall Synthesis Inhibitor. Proceedings of the 1st International Conference on Science and Technology; 2019 May 2-3; Makassar, Indonesia. Ghent: EAI. doi:10.4108/eai.2-5-2019.2284686
25. Thawabteh, A., Juma, S., Bader, M., Karaman, D., Scrano, L., Bufo, S.A., et al. 2019. The Biological Activity of Natural Alkaloids Against Herbivores, Cancerous Cells and Pathogens. Toxins (Basel). 11(11),656:1-28. doi:10.3390/toxins11110656
26. Dong, S., Yang, X., Zhao, L., Zhang, F., Hou, Z., & Xue, P. 2020. Antibacterial Activity and Mechanism of Action Saponins from Chenopodium quinoa Willd. Husks Against Foodborne Pathogenic Bacteria. Industrial Crops and Products. 149:1-14. doi:10.1016/j.indcrop.2020.112350
27. Kurhekar, J.V. 2016. Tannins-Antimicrobial Chemical Components. International Journal of Technology and Science. 9(3):5-9.
28. Maisetta, G., Batoni, G., Caboni, P., Esin, S., Rinaldi, A.C., & Zucca, P. 2019. Tannin Profile, Antioxidant Properties, and Antimicrobial Activity of Extracts from Two Mediterranean Species of Parasitic Plant Cytinus. BMC Complementary and Alternative Medicine. 19(82):1-11. doi:10.1186/s12906-019-2487-7
29. Pratasik, M.C.M., Yamlean, P.V.Y., & Wiyono, W.I. 2019. Formulasi dan Uji Stabilitas Fisik Sediaan Krim Ekstrak Etanol Daun Sesewanua (Clerodendron squamatum Vahl.). Pharmacon. 8(2):261-267.
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Published
2022-02-01
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Ardhany, S. D., Septia, S., & Novaryatiin, S. (2022). Formulasi dan Aktivitas Antibakteri Krim Anti Acne Ekstrak Etanol Bawang Dayak (Eleutherine bulbosa (Mill.) Urb.) terhadap Staphylococcus epidermidis: Formulation and Antibacterial Activity of Anti-acne Cream of Bawang Dayak Ethanol Extract (Eleutherine bulbosa (Mill.) Urb.) against Staphylococcus epidermidis. Jurnal Surya Medika (JSM), 7(2), 210–218. https://doi.org/10.33084/jsm.v7i2.3217
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