Optimasi Formulasi Sediaan Tablet Effervescent dari Ekstrak Etanol Tanaman Kalangkala (Litsea angulata) sebagai Antioksidan Menggunakan Metode SLD (Simplex Lattice Design)
Optimization of Effervescent Tablets Formulation From Ethanol Extract of Kalangkala Plant (Litsea angulata) as Antioxidant Using SLD (Simplex Lattice Design) Method
DOI:
https://doi.org/10.33084/jsm.v8i3.4496Keywords:
Kalangkala Leaves, Effevescent tablets, Simplex Lattice DesignAbstract
Free radicals trigger various diseases, such as respiratory disorders and cancer. Aware of the bad potential of free radicals, many people consume antioxidants to tackle free radicals. One of them is Kalangkala Plant (Litsea angulata), which contains flavonoids. The potential of Kalangkala plants as antioxidants is formulated in effervescent tablets. The effervescent tablet was evaluated using the Simplex Lattice Design (SLD) method to determine the most optimal formulation. The results showed that the most optimal preparation from the evaluation of powders was F2, while the results of the evaluation of tablets using the SLD method were the most optimal was F3. In addition, the antioxidant activity test using the DPPH method showed that Kalangkala Leaf extract had strong antioxidant activity.
Downloads
References
Kuspradini H and al et Potensi Tumbuhan Genus Litsea. - Samarinda : Mulawarman University Press, 2018.
Rohama, R., & Melviani, M. (2021). Formulasi dan Evaluasi Sediaan Obat Kumur (Mouthwash) dari Ekstrak Etanol Daun Kalangkala (Litsea angulata) sebagai Antiseptik Mulut. Jurnal Surya Medika (JSM), 7(1), 248-256.
Rohama, R., & Zainuddin, Z. (2021). Identifikasi Senyawa Metabolit Sekunder pada Ekstrak Daun Gayam (Inocarpus Fagifer Fosb) dengan Menggunakan KLT. Jurnal Surya Medika (JSM), 6(2), 125-129.
Sukmilawati, N., Rohama, R., & Manto, O. A. D. (2021, October). SCREENING OF PHOTOCHEMICALS AND ANTIOXIDANT ACTIVITIES OF LIME ROOT EXTRACTS (Citrus Aurantifolia (Cristm.) Swingle) USING DPPH METHOD. In International Conference on Health and Science (Vol. 1, No. 1, pp. 345-357).
Patel H.K and al et Formulation and Evaluation of Effervescent Tablet of Paracetamol and Ibuprofen. - [s.l.] : International Journal for Pharmaceutical Research Scholars., 2012. - 2 : Vol. 1.
Syahrina D and al et Optimasi Kombinasi Asam Sitrat dan Asam Tartrat sebagai Zat Pengasam pada Tablet Effervescent Ekstrak Ubi Jalar Ungu (Ipomoea batatas L.). Jurnal Surya Medika (JSM), 2021. - 1 : Vol. 7.
Noval and al et Formulasi Sediaan Tablet Effervescent dari Ekstrak Etanol Tanaman Bundung (Actinoscirpus grossus) sebagai Antioksidan. Jurnal Surya Medika (JSM), 2021. - 1 : Vol. 7.
Noval, N., & Malahayati, S. (2021). TEKNOLOGI PENGHANTARAN OBAT TERKENDALI.
Noval, N. (2021). Formulasi dan Teknologi Sediaan Solida (R. Fitria (ed.); Pertama). CV. Mitra Cendekia Media.
Aslani A and al et Design, formulation and evaluation of its physiochemical properties of acetaminophen, ibuprofen and caffein as effervescent tablet. Isfahan University of Medical Science, 2016. - 2 : Vol. 5.
Alawiyah R Formulasi Tablet Ekstrak Etanol Kulit Buah Rambutan (Nephelium lappaceum L.) dengan Variasi Kadar Polivynilpyrolidone dan Uji aktivitas antioksidan dengan Metode DPPH. Yogyakarta : Universitas Islam Indonesia, 2012.
SAFITRI, E. R., & Rohama, R. (2020). SKRINING FITOKIMIA SERTA UJI AKTIVITAS ANTIOKSIDAN EKSTRAK BUNGA KETEPENG CINA (Senna alata (L.) Roxb.) DENGAN METODE DPPH. Journal Pharmaceutical Care and Sciences, 1(1), 10-18.
Haryono I.A and al et Formulasi dan Evaluasi Tablet Effervescent dari Ekstrak Buah Tampoi (Baccaurea macrocarpa) Jurnal Surya Medika (JSM), 2022. - 2 : Vol. 7.
Indartantri K.B and al et Formulasi dan Evaluasi Floating System Tablet Difenhidramin HCl Menggunakan Kombinasi Matriks HPMC K4M dan Na. CMC. Jurnal Surya Medika (JSM), 2021. - 1 : Vol. 7.
Kelana and al et Formulasi dan evaluasi tablet kaptopril menggunakan amilum umbi talas dan HPMC yang dimodifikasi sebagai pengisi dan pengikat metode kempa langsung.Eksakta : Jurnal Ilmu-Ilmu MIPA, 2018.
Noorjannah and al et Uji Disolusi Terbanding Antara Sediaan Tablet Ramipril Generik Dan Bermerek. Journal Pharmaceutical Care and Sciences, 2020. - I : Vol. I
Anonim. (1979). Farmakope Indonesia, Edisi III. Departemen Kesehatan Republik Indonesia. Jakarta.
BPOM RI Peraturan Kepada Badan Pengawas Obat dan Makanan Republik Indonesia Nomor 12 Tahun 2014 Tentang Persyaratan Mutu Obat Tradisional. BPOM RI, 2014.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Rohama Rohama, Melviani Melviani, Noval Noval
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
All rights reserved. This publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording.
