Pengaruh Pemberian Leuprolide Acetat Terhadap Kadar IL-17A pada Mencit Model Andometriosis
The Effect of Leuprolide Acetat On IL-17A Levels in Endometriosis Model Mice
DOI:
https://doi.org/10.33084/jsm.v10i3.8972Keywords:
Endometriosis, IL-17ª, Leuprolide AcetatAbstract
Endometriosis adalah kelainan umum yang dikaitkan dengan nyeri, gejala gastrointestinal dan saluran kemih, infertilitas, dan kelelahan. Endometriosis didefinisikan oleh adanya lesi mirip endometrium yang sebagian besar ditemukan di panggul. Mekanisme yang berkontribusi terhadap etiologi penyakit ini meliputi perubahan jalur hormonal, inflamasi, dan nyeri IL-17A. Leuprolide Acetat adalah analog sintetik dari hormon pelepas gonadotropin (GnRH) yang terjadi secara alami, yang bertindak sebagai penghambat kuat sekresi gonadotropin hipofisis bila diberikan terus menerus pada dosis terapeutik. Penelitian ini bertujuan untuk melihat pengaruh pemberian Leuprolide Acetat terhadap Kadar IL-17A pada mencit model endometriosis. Sebanyak 15 ekor mencit di bagi menjadi 3 kelompok yaitu mencit sehat, mencit Endometriosis, mencit Endometriosis diberikan Leuprolide Acetat. Kadar IL-17A diukur dengan enzyme-linked immunosorbent assay (ELISA) pada masing-masing kelompok pengamatan. Dari hasil penelitian ini menunjukkan bahwa terdapat pengaruh pemberian Leuprolide Acetat terhadap kadar IL-17A pada mencit model endometriosis.
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