Ethnomedicine Study of Medicinal Plants for Therapy of Elderly Sleep Disorders in Tengger Tribe
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Submitted
3 June 2024
Published
30 August 2024
Keywords:
-
Elderly , Plants, Sickness , Tengger
Abstract
Ethnomedicine offers valuable insights into plant-based therapies, potentially leading to the discovery of novel drugs. Sleep disturbances, including difficulty falling asleep, maintaining sleep, and early morning awakening, are prevalent among the elderly population and can significantly worsen Alzheimer's disease progression. This study explores the medicinal plants utilized by the Tengger tribe's elderly population for treating sleep disorders. Employing a mixed-methods approach, the study involved qualitative data collection through snowball sampling and in-depth interviews with 99 elderly participants and three traditional healers of the Tengger tribe. Quantitative data was obtained through questionnaires administered during field surveys. Participants were selected based on specific criteria: elderly individuals over 60 years of age, native Tengger tribe members with a history of using medicinal plants for sleep disorders; traditional healers were required to be native Tengger tribe members with knowledge passed down through generations. The study identified a total of 11 medicinal plants used for sleep disorders. Five plant species emerged as the most dominant based on the highest citation value (FC) analysis: kale (Ipomoea reptans), agarwood (Aquilaria malaccensis), sintok (Cinnamomum sintoc), Broadleaf plantain (Plantago major), and soursop (Annona muricata). The most commonly used plant parts were leaves, bark, and roots. Traditional preparation methods included boiling and burning the plant materials. Notably, knowledge of these medicinal plants is primarily transmitted orally within the community. Our findings highlight five medicinal plants employed by the Tengger elderly to manage sleep disorders, with limited documented evidence of their efficacy.
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References
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25. Caro DC, Rivera DE, Ocampo Y, Franco LA, Salas RD. Pharmacological Evaluation of Mentha spicata L. and Plantago major L., Medicinal Plants Used to Treat Anxiety and Insomnia in Colombian Caribbean Coast. Evid Based Complement Alternat Med. 2018;2018:5921514. DOI: 10.1155/2018/5921514; PMCID: PMC6106973; PMID: 30158996
26. Triastuti A, Pradana DA, Setiawan ID, Fakhrudin N, Himmi SK, Widyarini S, et al. In vivo anti-inflammatory activities of Plantago major extract and fractions and analysis of their phytochemical components using a high-resolution mass spectrometry. Res Pharm Sci. 2022;17(6):665-76. DOI: 10.4103/1735-5362.359433; PMCID: PMC9872180; PMID: 36704431
27. Zubaidi SN, Nani HM, Kamal MSA, Qayyum TA, Maarof S, Afzan A, et al. Annona muricata: Comprehensive Review on the Ethnomedicinal, Phytochemistry, and Pharmacological Aspects Focusing on Antidiabetic Properties. Life. 2023;13(2):353. DOI: 10.3390/life13020353; PMCID: PMC9968120; PMID: 36836708
28. Hamid HA, Ramli ANM, Yusoff MM. Indole Alkaloids from Plants as Potential Leads for Antidepressant Drugs: A Mini Review. Front Pharmacol. 2017;8:96. DOI: 10.3389/fphar.2017.00096; PMCID: PMC5328930; PMID: 28293192
29. Bikomo EO, Ojokuku SA, Niemogha M. Annona muricata L., Stem-Bark Exhibit Antidepressant-Like Activity in SpragueDawley Rats. Trop J Nat Prod Res. 2023;7(6):3236-9. DOI: 10.26538/tjnpr/v7i6.26
30. Makuasa DAA, Ningsih P. The Analysis of Total Flavonoid Levels In Young Leaves and Old Soursop Leaves (Annona muricata L.) Using UV-Vis Sepctrofotometry Methods. J Appl Sci Eng Technol Educ. 2020;2(1):11-7. DOI: 10.35877/454RI.asci2133
31. Hassanpour SH, Doroudi A. Review of the antioxidant potential of flavonoids as a subgroup of polyphenols and partial substitute for synthetic antioxidants. Avicenna J Phytomed. 2023;13(4):354-76. DOI: 10.22038/ajp.2023.21774; PMCID: PMC10474916; PMID: 37663389
32. Spencer JPE. The interactions of flavonoids within neuronal signalling pathways. Genes Nutr. 2007;2(3):257-73. DOI: 10.1007/s12263-007-0056-z; PMCID: PMC2474943; PMID: 18850181
2. D'Almeida SA, Gbomor SE, Osaio-Kamara B, Olagunju MT, Abodunrin OR, Foláyan MNO. A scoping review of the use of traditional medicine for the management of ailments in West Africa. PLoS One. 2024;19(7):e0306594. DOI: 10.1371/journal.pone.0306594; PMCID: PMC11230574; PMID: 38976677
3. Pirintsos S, Panagiotopoulos A, Bariotakis M, Daskalakis V, Lionis C, Sourvinos G, et al. From Traditional Ethnopharmacology to Modern Natural Drug Discovery: A Methodology Discussion and Specific Examples. Molecules. 2022;27(13):4060. DOI: 10.3390/molecules27134060; PMCID: PMC9268545; PMID: 35807306
4. Junsongduang A, Kasemwan W, Lumjoomjung S, Sabprachai W, Tanming W, Balslev H. Ethnomedicinal Knowledge of Traditional Healers in Roi Et, Thailand. Plants. 2020;9(9):1177. DOI: 10.3390/plants9091177; PMCID: PMC7570034; PMID: 32927919
5. Snow AD, Castillo GM, Nguyen BP, Choi PY, Cummings JA, Cam J, et al. The Amazon Rain Forest Plant Uncaria Tomentosa (Cat’s Claw) and Its Specific Proanthocyanidin Constituents Are Potent Inhibitors and Reducers of Both Brain Plaques and Tangles. Sci Rep. 2019;9(1):561. DOI: 10.1038/s41598-019-38645-0; PMCID: PMC6365538; PMID: 30728442
6. Shin YJ, Midgley GF, Archer ERM, Arneth A, Barnes DKA, Chan L, et al. Actions to halt biodiversity loss generally benefit the climate. Glob Chang Biol. 2022;28(9):2846-74. DOI: 10.1111/gcb.16109; PMCID: PMC9303674; PMID: 35098619
7. Hellström A, Hellström P, Willman A, Fagerström C. Association between Sleep Disturbances and Leisure Activities in the Elderly : A Comparison between Men and Women. Sleep Disord. 2014;2014:595208. DOI: 10.1155/2014/595208; PMCID: PMC3915532; PMID: 24575303
8. Wong R, Lovier MA. Sleep Disturbances and Dementia Risk in Older Adults: Findings From 10 Years Of National U.S Prospective Data. Am J Prev Med. 2023;64(6):781–7. DOI: 10.1016/j.amepre.2023.01.008; PMID: 36707315
9. Miner B, Kryger MH. Sleep in the Aging Population. Sleep Med Clin. 2017;12(1):31-8. DOI: 10.1016/j.jsmc.2016.10.008; PMCID: PMC5300306; PMID: 28159095
10. Tsou M. Healthcare Service Utilization and Associated Factors in Community- Dwelling Elderly in Northern Taiwan : One Medical Center ’ s Experience. Int J Gerontol. 2018;12(2):144–9. DOI: 10.1016/j.ijge.2018.02.015
11. Fauziah E, Hartati S, Kamesyworo. The Effectiveness of Elderly Exercise in Decreasing the Level of Insomnia. J Appl Nurs Health. 2022;4(1):71-7. DOI: 10.55018/janh.v4i1.55
12. Jadid N, Kurniawan E, Himayani CES, Andriyani, Prasetyowati I, Purwani KI, et al. An ethnobotanical study of medicinal plants used by the Tengger tribe in Ngadisari village, Indonesia. PLoS One. 2020;15(7):e0235886. DOI: 10.1371/journal.pone.0235886; PMCID: PMC7357767; PMID: 32658902
13. Ramli MR, Malek S, Milow P, Aziz NJ. Traditional knowledge of medicinal plants in the Kampung Orang Asli Donglai Baru, Hulu Langat, Malaysia. Biodiversitas J Biol Div. 2021;22(3):1304-9. DOI: 10.13057/biodiv/d220329
14. Palinkas LA, Horwitz SM, Green CA, Wisdom JP, Duan N, Hoagwood K. Purposeful Sampling for Qualitative Data Collection and Analysis in Mixed Method Implementation Research. Adm Policy Ment Health. 2015;42(5):533-44. DOI: 10.1007/s10488-013-0528-y; PMCID: PMC4012002; PMID: 24193818
15. Abubakar AR, Haque M. Preparation of Medicinal Plants: Basic Extraction and Fractionation Procedures for Experimental Purposes. J Pharm Bioallied Sci. 2020;12(1):1-10. DOI: 10.4103/jpbs.jpbs_175_19; PMCID: PMC7398001; PMID: 32801594
16. Rabizadeh F, Mirian MS, Doosti R, Kiani-Anbouhi R, Eftekhari E. Phytochemical Classification of Medicinal Plants Used in the Treatment of Kidney Disease Based on Traditional Persian Medicine. Evid Based Complement Alternat Med. 2022;2022:8022599. DOI: 10.1155/2022/8022599; PMCID: PMC9357710; PMID: 35958915
17. Saikia K, Dey S, Hazarika SN, Handique GK, Thakur D, Handique AK. Chemical and biochemical characterization of Ipomoea aquatica: genoprotective potential and inhibitory mechanism of its phytochemicals against α-amylase and α-glucosidase. Front Nutr. 2023;10:1304903. DOI: 10.3389/fnut.2023.1304903; PMCID: PMC10772144; PMID: 38192648
18. Setiawan I. Hypnotic Effect of Ethanol Extract of Swamp Cabbage (Ipomoea aquatica Forsk.) in Male Swiss Webster Mice Induced by Phenobarbital. J Med Planta. 2021;2(1):93-100.
19. Astuti KI, Fitriyanti F. Uji Potensiasi Efek Sedatif-Hipnotik Ekstrak Etanol Kangkung Air (Ipomoea aquatic) Asal Gambut Kalimantan Selatan. Borneo J Pharmascientech. 2018;2(2):59–64. DOI: 10.51817/bjp.v2i2.198
20. Fan HR, Du WF, Zhu T, Wu YJ, Liu YM, Wang Q, et al. Quercetin Reduces Cortical GABAergic Transmission and Alleviates MK-801-Induced Hyperactivity. EBioMedicine. 2018;34:201-23. DOI: 10.1016/j.ebiom.2018.07.031; PMCID: PMC6116474; PMID: 30057312
21. Eissa MA, Hashim YZHY, Azziz SSSA, Salleh HM, Isa MLM, Warif NMA, et al. Phytochemical Constituents of Aquilaria malaccensis Leaf Extract and Their Anti-Inflammatory Activity against LPS/IFN-γ-Stimulated RAW 264.7 Cell Line. ACS Omega. 2022;7(18):15637-46. DOI: 10.1021/acsomega.2c00439; PMCID: PMC9096934; PMID: 35571776
22. Alamil JMR, Paudel KR, Chan Y, Xenaki D, Panneerselvam J, Singh SK, et al. Rediscovering the TherapeuticPotential of Agarwood in the Management of Chronic Inflammatory Diseases. Molecules. 2022;27(9):3038. DOI: 10.3390/molecules27093038; PMCID: PMC9104417; PMID: 35566388
23. Wang S, Wang C, Peng D, Liu X, Wu C. Agarwood Essential Oil Displays Sedative-Hypnotic Effects through the GABAergic System. Molecules. 2017;22(12):2190. DOI: 10.3390/molecules22122190; PMCID: PMC6149890; PMID: 29232839
24. Samuelsen AB. The traditional uses, chemical constituents and biological activities of Plantago major L. A review. J Ethnopharmacol. 2000;71(1-2). DOI: 10.1016/s0378-8741(00)00212-9; PMCID: PMC7142308; PMID: 10904143
25. Caro DC, Rivera DE, Ocampo Y, Franco LA, Salas RD. Pharmacological Evaluation of Mentha spicata L. and Plantago major L., Medicinal Plants Used to Treat Anxiety and Insomnia in Colombian Caribbean Coast. Evid Based Complement Alternat Med. 2018;2018:5921514. DOI: 10.1155/2018/5921514; PMCID: PMC6106973; PMID: 30158996
26. Triastuti A, Pradana DA, Setiawan ID, Fakhrudin N, Himmi SK, Widyarini S, et al. In vivo anti-inflammatory activities of Plantago major extract and fractions and analysis of their phytochemical components using a high-resolution mass spectrometry. Res Pharm Sci. 2022;17(6):665-76. DOI: 10.4103/1735-5362.359433; PMCID: PMC9872180; PMID: 36704431
27. Zubaidi SN, Nani HM, Kamal MSA, Qayyum TA, Maarof S, Afzan A, et al. Annona muricata: Comprehensive Review on the Ethnomedicinal, Phytochemistry, and Pharmacological Aspects Focusing on Antidiabetic Properties. Life. 2023;13(2):353. DOI: 10.3390/life13020353; PMCID: PMC9968120; PMID: 36836708
28. Hamid HA, Ramli ANM, Yusoff MM. Indole Alkaloids from Plants as Potential Leads for Antidepressant Drugs: A Mini Review. Front Pharmacol. 2017;8:96. DOI: 10.3389/fphar.2017.00096; PMCID: PMC5328930; PMID: 28293192
29. Bikomo EO, Ojokuku SA, Niemogha M. Annona muricata L., Stem-Bark Exhibit Antidepressant-Like Activity in SpragueDawley Rats. Trop J Nat Prod Res. 2023;7(6):3236-9. DOI: 10.26538/tjnpr/v7i6.26
30. Makuasa DAA, Ningsih P. The Analysis of Total Flavonoid Levels In Young Leaves and Old Soursop Leaves (Annona muricata L.) Using UV-Vis Sepctrofotometry Methods. J Appl Sci Eng Technol Educ. 2020;2(1):11-7. DOI: 10.35877/454RI.asci2133
31. Hassanpour SH, Doroudi A. Review of the antioxidant potential of flavonoids as a subgroup of polyphenols and partial substitute for synthetic antioxidants. Avicenna J Phytomed. 2023;13(4):354-76. DOI: 10.22038/ajp.2023.21774; PMCID: PMC10474916; PMID: 37663389
32. Spencer JPE. The interactions of flavonoids within neuronal signalling pathways. Genes Nutr. 2007;2(3):257-73. DOI: 10.1007/s12263-007-0056-z; PMCID: PMC2474943; PMID: 18850181
Authors
1.
Lahardo D, Ekasari W, Widyawaruyanti A. Ethnomedicine Study of Medicinal Plants for Therapy of Elderly Sleep Disorders in Tengger Tribe. Borneo J Pharm [Internet]. 2024Aug.30 [cited 2024Dec.21];7(3):306-14. Available from: https://journal.umpr.ac.id/index.php/bjop/article/view/7272
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