Potential of Indonesian Plants as Polymicrobial Anti-Biofilm

Rafika Sari (1) , Sylvia Utami Tunjung Pratiwi (2) , Yosi Bayu Murti (3) , Ema Damayanti (4)
(1) Tanjungpura University , Indonesia
(2) Universitas Gadjah Mada , Indonesia
(3) Universitas Gadjah Mada , Indonesia
(4) National Research and Innovation Agency , Indonesia

Abstract

Biofilm infection occurs in 80% of chronic infections caused by 60% of biofilms from plankton cells and polymicrobial biofilms. Due to synergistic interactions between species, infections caused by polymicrobial biofilms are more virulent than monospecies biofilm infections. New anti-biofilm candidates are constantly being developed by tracing the content of active compounds from medicinal plants native to Indonesia. The need to find new plant sources that have the potential as anti-biofilms is increasingly needed along with increasing microbial resistance. Various studies show that active compounds that have anti-biofilm potential are polyphenols, quercetin, curcumin, gallic acid, and ferulic acid. The mechanism of action of anti-biofilms is through the prevention of attachment and formation of biofilms, inhibition of quorum sensing, and inhibition of gene expression in microbes.

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Authors

Sylvia Utami Tunjung Pratiwi
sylvia_pratiwi@ugm.ac.id (Primary Contact)
Yosi Bayu Murti
Ema Damayanti
Author Biographies

Rafika Sari, Tanjungpura University

Doctoral Student in Pharmacy Science, Universitas Gadjah Mada, Sleman, Special Region of Yogyakarta, Indonesia

Department of Pharmacy, Universitas Tanjungpura, Pontianak, West Kalimantan, Indonesia

Sylvia Utami Tunjung Pratiwi, Universitas Gadjah Mada

Department of Pharmaceutical Biology, Universitas Gadjah Mada, Sleman, Special Region of Yogyakarta, Indonesia

Yosi Bayu Murti, Universitas Gadjah Mada

Department of Pharmaceutical Biology, Universitas Gadjah Mada, Sleman, Special Region of Yogyakarta, Indonesia

Ema Damayanti, National Research and Innovation Agency

Research Center for Food Processing and Technology, National Research and Innovation Agency of the Republic of Indonesia, Gunungkidul, Special Region of Yogyakarta, Indonesia

1.
Sari R, Pratiwi SUT, Murti YB, Damayanti E. Potential of Indonesian Plants as Polymicrobial Anti-Biofilm. Borneo J Pharm [Internet]. 2024Feb.29 [cited 2025Mar.21];7(1):63-79. Available from: https://journal.umpr.ac.id/index.php/bjop/article/view/5645

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