Pengaruh Pemberian Obat Anti Tuberkulosisi (OAT) Terhadap Jumlah Trombosit pada Pasien TB Paru di BKPM Purwokerto
The Effect of Anti Tuberkulosis Drug (OAT) Towards the Number of Pulmonary TB Patients at BKPM Purwokerto
DOI:
https://doi.org/10.33084/jsm.v9i2.5727Keywords:
Obat Anti Tuberkulosis, Trombosit, Tuberkulosis Paru, 0 Bulan, 2 Bulan, 6 BulanAbstract
Pulmonary tuberculosis (TB) is an infection of the lungs characterized by pulmonary infiltrates and the formation of caseous granulomas, fibrosis, and cavities. It can be caused by the risk of transmission of the acid-fast bacillus Mycobacterium tuberculosis. One supportive treatment for pulmonary TB is the administration of anti-tuberculosis drugs (OAT). The content of rifampicin in the anti-tuberculosis drug can cause side effects of hemorrhagic disorders, namely thrombocytopenia. This study aims to determine the effect of giving OAT on platelet counts in TB patients in treatment phases of 0, 2, and 6 months at BKPM Purwokerto (Balai Kesehatan Paru Masyarakat). This was a type of analytic observational study with a cross-sectional design. Patients with pulmonary TB in treatment phase 0 were 15 at two months and 15 at six months in this study. Sampling was carried out by purposive sampling with inclusion and exclusion criteria. From this analysis, it is known that the data used the one-way ANOVA test. The results obtained have a p-value of 0.101 (p 0.05), so it can be concluded that there is no effect of the administration of OAT on platelet counts in TB patients in the treatment phases of 0, 2, and 6 months.
Downloads
References
Abbas, A. (2017). Monitoring Efek Samping Obat Anti-Tuberkulosis (OAT) pada Pengobatan Tahap Intensif Penderita TB Paru di Kota Makassar. Journal of Agromedicine and Medical Sciences, 3(1), 19–24.
Andayani, S., & Astuti, Y. (2017). Prediksi Kejadian Penyakit Tuberkulosis Paru Berdasarkan Usia di Kabupaten Ponorogo Tahun 2016-2020. Indonesian Journal for Health Sciences, 1(2), 29–33. https://doi.org/10.24269/ijhs.v1i2.482
Aprianto, Sudarsono, T. A., Wardani, D. P. K., & Rahaju, M. (2022). Comparison of Ureum and Creatinine Levels Pulmonary Tuberculosis in Phase 0 and 6 Months Treatment. Jurnal Ilmu Dan Teknologi Kesehatan, 9(2), 14–24. https://doi.org/10.32668/jitek.v10il.927
Astuti, R. P. (2018). Pengaruh Pengobatan Tuberkulosis terhadap Jumlah Trombosit pada Pasien Tuberkulosis Paru 2 dan 5 Bulan. Semarang: Universitas Muhammadiyah Semarang.
Baharuddin, R. M. (2018). Perbandingan Panduan Nasional Tatalaksana Tuberkulosis Tahun 2014 di Indonesia dan Panduan Terbaru Terapi untuk Terduga TB menurut WHO Tahun 2017. JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia, 6(1), 1–8.
Chandramouli. (2021). Case Series of Three Patients with Rifampicin-Induced Thrombocytopenia. Journal of Health and Allied Sciences, 11(01), 44–46. https://doi.org/10.1055/s-0040-1718608
Ergiana, S. D., Wardani, D. P. K., Sudarsono, T. A., & Mulyanto, A. (2022). Hubungan Kadar C-Reactive Protein dengan Jumlah Leukosit Penderita Tuberkulosis Paru pada Fase pengobatan 0 dan 2 bulan di BKPM Purwokerto. Jurnal Surya Medika, 8(2), 62–77. https://doi.org/10.33084/jsm.v8i2.3482
Gannika, L. (2016). Tingkat Pengetahuan Keteraturan Berobat dan Sikap Klien terhadap Terjadinya Penyakit TBC Paru di Ruang Perawatan I Dan II RS Islam Faisal Makassar. Jurnal Ilmiah Kesehatan Sandi Husada, 4(1), 55–62. https://doi.org/10.35816/jiskh.v4i1.86
Greinacher, A., & Selleng, S. (2016). How I Evaluate and Treat Thrombocytopenia in the Intensive Care Unit Patient. Blood, 128(26), 3032–3042. https://doi.org/10.1182/blood-2016-09-693655
Haliza, N. E., Wardani, D. P. K., Sudarsono, T. A., & Mulyanto, A. (2022). Hubungan Kadar C-Reactive Protein dengan Jumlah Neutrofil Penderita Tuberkulosis Paru pada Fase Pengobatan 0 dan 6 Bulan di BKPM Purwokerto. Jurnal Surya Medika, 8(2), 37–44. https://doi.org/10.33084/jsm.v8i2.3482
Hasanah, U. (2019). Gambaran Jumlah Trombosit pada Penderita Tuberkulosis Paru Sebelum dan Sesudah Dua Bulan Mengonsumsi Obat Anti Tuberkulosis di RS. Khusus Paru Medan. POLITEKNIK KESEHATAN KEMENKES RI MEDAN.
Indah, M. (2018). Tuberkulosis ( TB ). In M. Indah (Ed.), Tuberkulosis (p. 9). Jakarta Selatan: Infodatin. Retrieved from www.kemenkes.go.id
Jaya, H., & Mediarti, D. (2017). Faktor-Faktor yang Berhubungan dengan Tuberkulosis Paru Relaps pada Pasien di Rumah Sakit Khusus Paru provinsi Sumatera Selatan Tahun 2015-2016. Jurnal Kesehatan Palembang (JPP), 12(1), 71–82.
Kassa, E., Enawgaw, B., Gelaw, A., & Gelaw, B. (2016). Effect of Anti-Tuberculosis Drugs on Hematological Profiles of Tuberculosis Patients Attending at University of Gondar Hospital, Northwest Ethiopia. BMC Hematology, 16(1), 1–11. https://doi.org/10.1186/s12878-015-0037-1
Kemenkes. (2019). Pedoman Nasional Pelayanan Kedokteran Tata Laksana Tuberkulosis. In Kemenkes (Ed.), Menteri Kesehatan Republik Indonesia. Jakarta.
Kementerian Kesehatan Republik Indonesia. (2017). Petunjuk Teknis Pemeriksaan TB Menggunakan Tes Cepat Molekuler. Retrieved from www.tbindonesia.or.id
Kesek, J. F. N., Sugeng, C. E. C., & Polii, E. B. I. (2019). Gambaran Pasien Tuberkulosis Paru Usia Produktif di RSUP Prof. Dr. R. D. Kandou Manado Periode Tahun 2014-2015. Medical Scope Journal, 1(1), 36–38. https://doi.org/10.35790/msj.1.1.2019.26816
Kirwan, D. E., Chong, D. L. W., & Friedland, J. S. (2021). Platelet Activation and the Immune Response to Tuberculosis. Frontiers in Immunology, 12(1), 1–11. https://doi.org/10.3389/fimmu.2021.631696
Kuwabara, G., Tazoe, K., Imoto, W., Yamairi, K., Shibata, W., Oshima, K., … Kakeya, H. (2021). Isoniazid-induced Immune Thrombocytopenia. Internal Medicine, 60(22), 3639–3643. https://doi.org/10.2169/internalmedicine.6520-20
Pangaribuan, L., Kristina, Perwitasari, D., Tejayanti, T., & Lolong, D. B. (2020). Faktor-Faktor yang Mempengaruhi Kejadian Tuberkulosis pada Umur 15 Tahun ke Atas di Indonesia. Buletin Penelitian Sistem Kesehatan, 23(1), 10–17. https://doi.org/10.22435/hsr.v23i1.2594
Prameswari, R. D., & Wahyudi, A. I. (2015). Gambaran Jumlah Trombosit terhadap Penderita Tuberkulosis Sebelum dan Sesudah Mengkonsumsi Obat Anti Tuberkulosis Paket (OAT) di Puskesmas Kecamatan Kwanyar Kabupaten Bangkalan. Jurnal Sains, 5(10), 1–5.
Pratiwi, E. P., Rohmawaty, E., & Kulsum, I. D. (2018). Efek Samping Obat Anti Tuberkulosis Kategori I dan II Pasien Tuberkolosis Paru Dewasa di Rumah Sakit Hasan Sadikin. Indonesian Journal of Clinical Pharmacy, 7(4), 252–259. https://doi.org/10.15416/ijcp.2018.7.4.252
Qo’imah, A. N., Wardani, D. P. K., Sudarsono, T. A., & Mulyanto, A. (2022). Comparison of TSH Levels Pulmonary Tuberculosis Patients at The Phase 0 and 6 Months Treatment. Jurnal Ilmu Dan Teknologi Kesehatan, 10(1), 99–107. https://doi.org/10.32668/jitek.v10i1.910
Rampa, E., Fitrianingsih, & Sinaga, H. (2020). Hasil Pemeriksaan Leukosit, Trombosit dan Hemoglobin pada Penderita Tuberkulosis yang Mengkonsumsi OAT di RSAL Dr. Soedibjo Sardadi Kota Jayapura. Global Health Science, 5(2), 78–83. Retrieved from https://jurnal.csdforum.com/index.php/GHS/article/view/389
Riyadi, A. N. R. (2020). Studi Penggunaan Kombinasi Dosis Tetap (KDT) Kategori 1 Tahap Lanjutan pada Pasien Tuberkulosis Paru Rawat Inap.
Safitri, S., Sudarsono, T. A., Kusuma, D. P., & Wijayanti, L. (2022). Hubungan Kadar C-Reactive Protein (CRP) dengan Jumlah Limfosit pada Pasien TB Paru di BKPM Purwokerto. Jurnal Surya Medika, 8(3), 10–16.
Sari, I. D., Yuniar, Y., & Syaripuddin, M. (2014). Studi Monitoring Efek Samping Obat Antituberkulosis FDC Kategori 1 di Provinsi Banten dan Provinsi Jawa Barat. Media Litbangkes, 24(1), 28–35. Retrieved from http://www.cdkjournal.com/index.php/CDK/article/view/1128
Sugiarti, M. (2015). Pengaruh Khemoterapi terhadap Jumlah Trombosit Pasien Penderita Kanker di RS Abdul Moeloek Provinsi Lampung. Jurnal Analis Kesehatan, 4(2), 450–455.
Thuraidah, A., Astuti, R. A. W., & Rakhmina, D. (2017). Anemia dan Lama Konsumsi Obat Anti Tuberkulosis. Medical Laboratory Technology Journal, 3(2), 42–46.
Yusuf, M. I., Firdayanti, & Salmawati. (2018). Gambaran Nilai Trombosit Pada pasien Tuberculosis Paru yang Mendapat Paket Obat Anti Tuberkulosis (OAT) di Rumah Sakit Umum Daerah Kota Kendari. Jurnal Analis Kesehatan Kendari, III(1), 104–110.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Ika Wulan Nuri Anggreani, Tantri Analisawati Sudarsono, Dita Pratiwi Kusuma Wardani, Minto Rahaju
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
All rights reserved. This publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording.
