Simplicia and Extracts Standardization from Jualing Leaves (Micromelum minutum Wight & Arn.) from South Kalimantan
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Micromelum minutum, Standardization, Simplicia, Specific parameter, Non-specific parameter
Abstract
Jualing (Micromelum minutum Wight & Arn.) is a plant from South Kalimantan that has the potential to be developed as natural medicine. This study aims to establish standardization which includes specific and non-specific parameters of M. minutum leaf simplicia and extracts from three growing locations, namely Banua Botanical Garden, Sultan Adam Forest Park, and Forest Areas with Specific Objects of Rantau, South Kalimantan. The method of setting standardization parameters refers to the Indonesian Herbal Pharmacopoeia and General Standard Extracts Parameters. Organoleptic standardization of simplicia is brownish-green, has a distinctive odor, has a bitter and slightly spicy taste. Microscopic observations showed the presence of stomata, cell walls, cytoplasm, calcium oxalate crystals, upper epidermis, palisade tissue, spongy tissue, cortex, xylem, phloem, lower epidermis, and trichomes. Water content test showed the results of 21.9-22.07%; ethanol extract content of 12.87-13.17%; drying losses 4.64-4.84%; total ash content of 6.04-6.14%; acid insoluble ash content 1.13-1.19%; Pb levels of 0.022-0.025 mg/kg; Cd levels of 0.017-0.020 mg/kg; and Hg levels <0.0004 mg/kg. Extract standardization shows thick green-black, thick-smelling extract and bitter taste. Micromelum minutum leaves contain alkaloids, flavonoids, saponins, terpenoids, tannins, anthraquinones, phenols, and glycosides. Thin Layer Chromatography profiles show the similarity of chemical compounds in each growth location. Other parameters are extract yield of 8.08-8.32%; moisture content of 6.07-6.27%; total ash content of 4.22-4.27%; and acid insoluble ash content 1.11-1.12%. All standardization parameters meet the requirements in the Media Materia Indonesia and the Republic of Indonesia Drug and Food Control Center.
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References
Hardiana, R., Rudiyansyah, Zaharah, T.A. 2012. Aktivitas Antioksidan Senyawa Golongan Fenol dari Beberapa Jenis Tumbuhan Famili Malvaceae. Jurnal Kimia Khatulistiwa. 1(1): 8-13.
Heriyanto, N.M., Subiandono, E. 2011. Penyerapan Polutan Logam berat (Hg, Pb dan Cu) Oleh Jenis-Jenis Mangrove. Jurnal Penelitian Hutan dan Konservasi Alam. 8(2):177-188. https://doi.org/10.20886/jphka.2011.8.2.177-188
Isnawati, A., Alegantina, S., Raini, M., Nikmah, B. 2004. Karakterisasi Simplisia dan Ekstrak Daun Strobilanthus crispus. Media Penelitian dan Pengembangan Kesehatan. 14(2):20-25.
Ministry of Health Republic of Indonesia. 2014. Farmakope Indonesia Edisi Kelima. Jakarta: Ministry of Health Republic of Indonesia.
Ministry of Health Republic of Indonesia. 2008. Farmakope Herbal Indonesia Edisi Pertama. Jakarta: Ministry of Health Republic of Indonesia.
Ministry of Health Republic of Indonesia. 2000. Parameter Standar Umum Ekstrak Tumbuhan Obat Edisi I. Jakarta: Directorate General of Drug and Food Control and Directorate of Traditional Medicines Control.
Najib, A., Malik, A. Ahmad, A.R., Handayani, V., Syarif, R.A., Waris, R. 2017. Standarisasi Ekstrak Air Daun Jati Belanda dan Teh Hijau. Jurnal Fitofarmaka Indonesia. 4(2):241-245. https://doi.org/10.33096/jffi.v4i2.268
National Agency for Drug and Food Control Republic of Indonesia. 2014. Peraturan Kepala Badan Pengawas Obat dan Makanan Republik Indonesia. Nomor 12 Tahun 2014 tentang Persyaratan Mutu Obat Tradisional. Jakarta: National Agency for Drug and Food Control Republic of Indonesia.
Nooron, N., Athipornchai, A., Suksamrarn, A., Chiabchalard, A. 2017. Mahanine Enhances the Glucose-Lowering Mechanisms in Skeletal Muscle and Adipocyte Cells. Biochemical and Biophysical Research Communications. 494(1-2):101-106. https://doi.org/10.1016/j.bbrc.2017.10.075
Panjaitan, E.N., Saragih, A., Purba, D. 2012. Formulasi Gel dari Ekstrak Rimpang Jahe Merah (Zingiber officinale Roscoe). Journal of Pharmaceutics and Pharmacology. 1(1):9-20.
Pasaribu, C.A., Sarifuddin, S., Marbun, P. 2017. Kandungan Logam Berat Pb Pada Kol Dan Tomat Di Beberapa Kecamatan Kabupaten Karo. Agroekoteknologi. 5(2):355-361.
Ratnani, R.D., Hartati, I., Anas, Y., Endah, D.P., Khilyati, D.D. 2017. Standardisasi Spesifik dan Non Spesifik Ekstraksi Hidrotropi Andrographolid dari Sambiloto (Andrographis paniculata). In Prosiding Seminar Nasional Peluang Herbal sebagai Alternative Medicine, Fakultas Farmasi, Universitas Wahid Hasyim. Semarang: Universitas Wahid Hasyim, 147-155.
Roy, S., Dutta, D., Satyavarapu, E.M., Yadav, P.K., Mandal, C., Kar, S., Mandal, C. 2017. Mahanine Exerts In Vitro and In Vivo Antileishmanial Activity by Modulation of Redox Homeostasis. Scientific reports. 7(4141): 1-16. https://doi.org/10.1038/s41598-017-03943-y
Saefudin, A., Rahayu, A., Teruna, H. Y. 2011. Standarisasi Bahan Obat Alam 2. Yogyakarta: Graha Ilmu.
Setyorini, H.A., Kurniatri, A.A., Adelina, R., Adelina, A. 2016. Karakterisasi Mutu Ekstrak Daun Sirsak (Annona muricata L.) dari Tiga Tempat Tumbuh. Buletin Penelitian Kesehatan. 44(4): 279-286. http://dx.doi.org/10.22435/bpk.v44i4.5184.279-286
Suryanto, E., Syaifuddin. 2017. Tumbuhan Obat di KHDTK Rantau, Kalimantan Selatan. Bogor: Forda Press.
Sutomo, S., Azhari, H., Arnida, A., Fadlilaturrahmah, F., Yunus, R. 2017. Isolasi Dan Identifikasi Senyawa Antioksidan dari Buah Kasturi (Mangifera casturi Kosterm.). Jurnal Pharmascience. 4(2):246-254. http://dx.doi.org/10.20527/jps.v4i2.5778
Uji, T. 2005. Studi Taksonomi Micrommelum blume (Rutaceae) di Indonesia. Biodiversitas. 6(2): 100-102. http://doi.org/10.13057/biodiv/d060206
Utami, Y. P., Umar, A.H., Syahruni, R., Kadullah, I. 2017. Standardisasi Simplisia dan Ekstrak Etanol Daun Leilem (Clerodendrum minahassae Teisjm. & Binn). Journal of Pharmaceutical and Medicinal Sciences. 2(1):32-39.
Warni, D., Karina, S., Nurfadillah, N. 2017. Analisis Logam Pb, Mn, Cu dan Cd Pada Sedimen di Pelabuhan Jetty Meulaboh, Aceh Barat. Jurnal Ilmiah Mahasiswa Kelautan Perikanan Unsyiah. 2(2):246-253.
World Health Organization. 1998. Quality Control Methods for Medicinal Plant Materials. Switzerland: World Health Organization.
Zulharmitta, Z., Kasypiah, U., Rivai, H. 2017. Pembuatan dan Karakterisasi Ekstrak Kering Daun Jambu Biji (Psidium guajava L.). Jurnal Farmasi Higea. 4(2):147-157.
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