A Review of Anti-hyperglycemic Effects of Curry Leaf Tree (Murraya koenigii)
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Submitted
26 February 2022
Published
31 May 2022
Keywords:
-
Curry leaf tree, Traditional Medicine, Review, Murraya koenigii, Diabetes
Abstract
Diabetes mellitus is becoming a metabolic disease that is defined by the level of hyperglycemia. Nowadays, it has a serious threat to public healthiness in throughout the world. Constituents and extracts isolated from diverse natural resources, mainly plants, have constantly been a rich store for controlling and treating diabetes problems. Numerous researches are ongoing to identify the suitable traditional medical drugs, medicinal herbs, and resources for managing this condition. Murraya koenigii Spreng (family Rutaceae) is commonly known as a ‘curry leaf tree’ locally. It is widely scattered in India and Sri Lanka, and leaves are commonly used for cooking. And also mainly used for various health conditions such as diabetes, anemia, diarrhea, and others. The present review aimed to critically review the anti-hyperglycemic effect of the M. koenigii based on the review, in vitro, in vivo, and clinical studies. Based on this review, the M. koenigii possess flavonoids, phenols, saponins, alkaloids, tannins, and cardiac glycosides. It has shown a potential anti-hyperglycemic effect on induced diabetic rats. This review reported the potential of M. koenigii and its extract to be a high-value dietary product in terms of its anti-hyperglycemic effects and industrial profits. Therefore, the present review supports the researchers and readers/users to realize the importance of using M. koenigii in managing diabetes mellitus. Further, this review provides a valuable document for future scientific-related clinical trials in diabetic patients.
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References
1. Chawla A, Chawla R, Jaggi S. Microvasular and macrovascular complications in diabetes mellitus: Distinct or continuum? Indian J Endocrinol Metab. 2016;20(4):546-51. doi:10.4103/2230-8210.183480
2. Hu FB. Globalization of diabetes: the role of diet, lifestyle, and genes. Diabetes Care. 2011;34(6):1249-57. doi:10.2337/dc11-0442
3. Lin X, Xu Y, Pan X, Xu J, Ding Y, Sun X, et al. Global, regional, and national burden and trend of diabetes in 195 countries and territories: an analysis from 1990 to 2025. Sci Rep. 2020;10(1):14790. doi:10.1038/s41598-020-71908-9
4. Tran N, Pham B, Le L. Bioactive Compounds in Anti-Diabetic Plants: From Herbal Medicine to Modern Drug Discovery. Biology. 2020;9(9):252. doi:10.3390/biology9090252
5. Jacob B, Narendhirakannan RT. Role of medicinal plants in the management of diabetes mellitus: a review. 3 Biotech. 2019;9(1):4. doi:10.1007/s13205-018-1528-0
6. Kesari AN, Kesari S, Singh SK, Gupta RK, Watal G. Studies on the glycemic and lipidemic effect of Murraya koenigii in experimental animals. J Ethnopharmacol. 2007;112(2):305-11. doi:10.1016/j.jep.2007.03.023
7. Jain V, Momin M, Laddha K. Murraya Koenigii: An Updated Review. Int J Ayurvedic Herb Med. 2012;2(4):607-27.
8. Muthulinggam N, Partiban S. Murraya koenigii (curry leave)- A review on its potential. Int J PharmTech Res. 2015;7(4):566-72.
9. Saini SC, Reddy GBS. A Review on Curry Leaves (Murraya koenigii): Versatile Multi-Potential Medicinal Plant. Am J Phyto Clin Ther. 2015;3(4):363-8.
10. Saini SC, Reddy GBS. Murraya koenigii. IOSR J Pharm Biol Sci. 2013;7(6):15-8.
11. Muthumani P, Venkatraman S, Ramseshu K, Meera R, Devi P, Kameswari B, et al. Pharmacological studies of anticancer, anti-inflammatory activities of Murraya koenigii (Linn) Spreng in experimental animals. J Pharm Sci Res. 2009;1(3):137-41.
12. Debosree G, Firdaus SB, Mitra E, Dey M, Bandyopadhyay D. Protective effect of aqueous leaf extract of murraya koenigii against lead induced oxidative stress in rat liver, heart and kidney: a dose response study. Asian J Pharm Clin Res. 2012;5(Suppl 4):54–9.
13. Mittal J, Jain M, Gilhotra R, Singh RP. Curry leaf (Murraya koenigii): a spice with medicinal property. MOJ Biol Med. 2017;2(3):236-56. doi:10.15406/mojbm.2017.02.00050
14. Ito C, Itoigawa M, Nakao K, Murata T, Tsuboi M, Kaneda N, et al. Induction of apoptosis by carbazole alkaloids isolated from Murraya koenigii. Phytomedicine. 2006;13(5):359–65. doi:10.1016/j.phymed.2005.03.010
15. Iyer D, Uma Devi P. Phyto-pharmacology of Murraya koenigii (L.). Pharmacogn Rev. 2008;2(3):180-4.
16. Kureel SP, Kapil RS, Popli SP. Two novel alkaloids from Murraya koenigii spreng: mahanimbicine and bicyclomahanimbicine. Chem Ind. 1970;29:958.
17. Adebajo CA, Olugbade TA, Elujoba AA, Aladesanmi AJ, Reisch J. 2”, 3” Epoxyindicolactone from Murraya koenigii. Niger J Nat Prod Med. 1997; 1(1):21–4. doi:10.4314/njnpm.v1i1.11794
18. Handral HK, Jha PK, Shruthi SD. Pharmacognostic and phytochemical studies on the leaves of Murraya koenigii L Spreng. Pharmacophore. 2010;1(3):231-8.
19. Ajay S, Rahul S, Sumit G, Paras M, Mishra A, Gaurav A. Comprehensive review: Murraya koenigii Linn. Asian J Pharm Life Sci. 2011; 1(4):417-25.
20. Batool S, Khera RA, Hanif MA, Ayub MA, Memon S. Medicinal Plants of South Asia. Amsterdam: Elsevier; 2020. Chapter 14, Curry Leaf; p.179-90. doi:10.1016/B978-0-08-102659-5.00014-8
21. Abeysinghe DT, Alwis DDDH, Kumara KAH, Chandrika UG. Nutritive Importance and Therapeutics Uses of Three Different Varieties (Murraya koenigii, Micromelum minutum, and Clausena indica) of Curry Leaves: An Updated Review. Evid Based Complementary Altern Med. 2021;2021:5523252. doi:10.1155/2021/5523252
22. Joseph B, Jini D. Insight in to the hypoglycemic effect of Traditional Indian Herbs used in the Treatment of Diabetes. Res J Medicinal Plant. 2011;5(4):352-76. doi:10.17311/rjmp.2011.352.376
23. Matheka DM, Alkizim FO. Complementary and alternative medicine for type 2 diabetes mellitus: Role of medicinal herbs. J Diabetes Endocrinol. 2012;3(4):44-56. doi:10.5897/JDE12.008
24. Qais N, Jahan S, Shafiullah MS. A Review on Anti-diabetic Plants. Dhaka Univ J Pharm Sci. 2018;17(1):139-52. doi:10.3329/dujps.v17i1.37130
25. Thakur G, Pal K, Mitra A, Mukherjee S, Basak A, Rousseau D. Some Common Anti-diabetic Plants of the Indian Subcontinent. Food Rev Int. 2010;26(4):364-85. doi:10.1080/87559129.2010.496024
26. Handral HK, Pandith A, Shruthi SD. A Review on Murraya Koenigii: Multi potential Medicinal Plant. Asian J Pharm Clin Res. 2012;5(4):5-14.
27. Nouman SM, Shehzad A, Butt MS, Khan MI, Tanveer M. Phytochemical profiling of curry (Murraya koenijii) leaves and its health benefits. Pak J Food Sci. 2015;25(4):204-15.
28. Jacob B, Narendhirakannan RT. Role of medicinal plants in the management of diabetes mellitus: a review. 3 Biotech. 2019; 9:4. doi:10.1007/s13205-018-1528-0
29. Goel A, Sharma A, Kulshrestha S. A Phytopharmacological Review on Murraya koenigii: An Important Medicinal Plant. Int J Pharm Sci Rev Res. 2020;62(2):113-9.
30. Singh S. Omreb PK, Mohanc SM. Curry Leaves (Murraya koenigii Linn. Sprengal)- A Mircale Plant. Indian J Sci Res. 2014;4(1):46-52.
31. Singh J, Singh J, Kaur S. Herbal Interventions in Managing Diabetes Mellitus: A Review. Plant Arch. 2020;20(2):2781-91.
32. Singh AG. Murraya Koenigii (L.) Spreng-Curry Leaves/Mitho Nim - A Miracle Plant. Butwal Campus J. 2020; 3(1):125-30. doi:10.3126/bcj.v3i1.36515
33. Balakrishnan R, Vijayraja D, Jo SH, Ganesan P, Su-Kim I, Choi DK. Medicinal Profile, Phytochemistry, and Pharmacological Activities of Murraya koenigii and its Primary Bioactive Compounds. Antioxidants. 2020;9(2):101. doi:10.3390/antiox9020101
34. Katoch A, Batta B, Kumar A, Sharma PC. Screening of Murraya koenigii (Curry) and Camellia sinensis (Tea) leaves for antimicrobial activity against strains of Staphylococcus aureus, Pseudomonas aeruginosa and Candida species and their Phytochemical Analysis. Int J Pharm Sci Res. 2013;4(2);862-8. doi:10.13040/IJPSR.0975%2D8232.4(2).862%2D68
35. James SA, Omwirhiren R Efe M, Joshua IA, Dutse I. Anti-diabetic Properties and Phytochemical Studies of Ethanolic Leaf Extracts of Murraya Koenigii and Telfairia Occidentalis on Alloxan-Induced Diabetic Albino Rats. Adv Life Sci Technol. 2016;49:57-66.
36. Igara CE, Omoboyowa DA, Ahuchaogu AA, Orji NU, Ndukwe MK. Phytochemical and nutritional profile of Murraya Koenigii (Linn) Spreng leaf. J Pharmacogn Phytochem. 2016;5(5):7-9.
37. Arsha T, Rani MAS. Preliminary Phytochemical and Anatomical Studies on Bark and Leaves of Murraya koenigii (L.) Spreng.; (Family-Rutaceae) and Pimenta dioica (L.) Merr.; (Family-Myrtaceae). Int J Res Appl Sci Eng Tech. 2019;7(3):656-61.
38. Pande M, Ingale S, Gupta S. The Pharmacognostic and phytochemical studies on the leaves of Murraya koenigii (L) Spreng. Indian J Sci Technol. 2009;2(3):53-4. doi:10.17485/IJST/2009/V2I3/29415
39. Vats M, Singh H, Sardana S. Phytochemical screening and antimicrobial activity of roots of Murraya koenigii (Linn.) Spreng. (Rutaceae). Braz J Microbiol. 2011;42(4):1569-73. doi:10.1590/s1517-838220110004000044
40. Garg D, Muley A, Khare N, Mara T. Comparative Analysis of Phytochemical Profile and Antioxidant Activity of Some Indian Culinary Herbs. Res J Pharm Biol Chem Sci. 2012;3(3):845-54.
41. Abubakar NA, Oise AE, Saidu AN. Phytochemical Constituents and Hypoglycemic Effect of Aqueous and Ethanolic Extracts of Murraya Koenigii in Alloxan-Induced Diabetic Rats. IOSR J Dent Med Sci. 2014;13(9):8-12.
42. Kumar NS, Simon N. In-vitro Antimicrobial Activity and Phytochemical Analysis of Murraya koenigii (L) Leaf Extracts. Glob J Sci Front Res C Biol Sci. 2016;16(1):29-32.
43. Thangavel A, Sahu O, Ponnappan S, Tadele A, Abawa G, Karthikeyan M. Evaluation of Preliminary Phytochemical Constituents and Antibacterial Activity of Edible Plants against Urinary tract causing Bacteria in Children. J Clin Microbiol Biochem Technol. 2017;3(2):24-30.
44. Anjaneyulu N, Alla T, Reddy SN, Ravali AS, Nikitha G, Srividhya PV, et al. Phytochemical Studies and Qualitative Analysis by TLC of Murraya Koenigii Bark Extract. Indo Am J Pharm Sci, 2017;4(4):904-9.
45. Jelita, Wirjosentono B, Tamrin, Marpaung L. Phytochemical Screening and Chemical Analysis of Ethanol Extract of Kari Leaves (Murayya koeginii) Using GC-MS Method. International Conference on Education, Science and Technology, J Phys Conf Series. 2019;1232:012012.doi:10.1088/1742-6596/1232/1/012012
46. Deepika T, Noorjahan CM. Phytochemical Screening and Antioxidant Property of Aqueous Murraya Koenigii (Curry Leaf) Extract. Int J Res Advent Technol. 2019;7(2):738-43.
47. Sharma R, Kumar U. Exploration and Phytochemical estimation of Murraya koenigii Leaves for Pharmaceutical Applications. Asian J Pharm Res. 2019;9(3):159-68. doi:10.5958/2231-5691.2019.00025.X
48. Sophiyamole L, Reshma JK, Prabhachandh RS, Babychan N. Phytochemical Analysis of Murraya Koenigii in Urban and Coastal Area. J Emerg Technol Innov Res. 2017;4(10):238-40.
49. Rajendran MP, Pallaiyan BB, Selvaraj N. Chemical composition, antibacterial and antioxidant profile of essential oil from Murraya koenigii (L.) leaves. Avicenna J Phytomed. 2014;4(3):200-14.
50. Ali G, Hawa ZEJ, Asmah R, Thiyagu D. Evaluation of Bioactive Compounds, Pharmaceutical Quality, and Anticancer Activity of Curry Leaf (Murraya koenigii L.). Evid Based Complementary Altern Med., 2014;2014:873803. doi:10.1155/2014/873803
51. Vinayagam R, Xiao J, Xu B. An insight into anti-diabetic properties of dietary phytochemicals. Phytochem Rev. 2017;16:535–53. doi:10.1007/s11101-017-9496-2
52. Aba PE, Asuzu IU. Mechanisms of actions of some bioactive anti-diabetic principles from phytochemicals of medicinal plants: A review. Indian J Nat Prod Resour. 2018;9(2):85-96.
53. Vinuthan MK, Girishkumar V, Ravindra, Jayaprakash JP, Narayana K. Effect of extracts of Murraya Koenigii leaves on the levels of blood glucose and plasma insulin in alloxan induced diabetic rats. Indian J Physiol Pharmacol. 2004;48(3):348–52.
54. Phatak RS, Khanwelkar CC, Matule SM, Datkhile KD, Hendre AS. Antihyperglycemic Activity of Murraya koenigii Leaves Extract on Blood Sugar Level in Streptozotocin-Nicotinamide Induced Diabetes in Rats. Biomed Pharmacol J. 2019;12(2):597-602. doi:10.13005/bpj/1679
55. Arulselvan P, Senthilkumar GP, Kumar DS, Subramanian S. Anti-diabetic effect of Murraya koenigii leaves on streptozotocin induced diabetic rats. Pharmazie. 2006;61:874–7.
56. Fauziah, Nindya NP, Firdus. The Effect of Curry Leaves (Murayya Koenigii L.) on Blood Glucose Levels in Alloxan Diabetic Mice (Mus Musculus). J Natural. 2014;14(1):23-9.
57. Lawal HA, Atiku MK, Khelpai DG, Wannan NN. Hypoglycaemic and hypolipidaemic effects of the aqueous leaf extract of Murraya koenigii in normal and alloxan – diabetic rats. Niger J Physiol Sci. 2008;23(1-2):37-40. doi:10.4314/njps.v23i1-2.54919
58. Tembhurne SV, Sakarkar DM. Anti-obesity and hypoglycemic effect of ethanolic extract of Murraya koenigii (L) leaves in high fatty diet rats. Asian Pac J Trop Dis. 2012;2(Suppl 1):S166-8. doi:10.1016/S2222-1808(12)60145-5
59. Sudha MJ, Viveka S, Rai M. Study of Hypoglycemic Effect of Murraya koenigii leaf extracts In Streptozotocin Induced Diabetic Rats. Int J Med Appl Sci. 2013;2(3):191-9.
60. Al-Ani IM, Santosa RI, Yankuzo MH, Saxena AK, Alazzawi KS. The Antidiabetic Activity of Curry Leaves “Murraya Koenigii” on the Glucose Levels, Kidneys, and Islets of Langerhans of Rats with Streptozotocin Induced Diabetes. Makara J Health Res. 2017;21(2):54-60. doi:10.7454/msk.v21i2.7393
61. El-Amin M, Virk P, Elobeid MA, Almarhoon ZM, Hassan ZK, Omer SA, et al. Anti-diabetic effect of Murraya koenigii (L) and Olea europaea (L) leaf extracts on streptozotocin induced diabetic rats. Pak J Pharm Sci. 2013;26(2):359-65.
62. Desai RR, Khanwelkar CC, Gidamudi S, Phatak RS, Jadhav S, Thorat, V, et al. Antidiabetic effect of Murraya koenigii leaves aqueous extract on blood sugar levels in alloxanized diabetic rats. Pravara Med Rev. 2019;11(2):19-24.
63. Bhat M, Zinjarde SS, Bhargava SY, Kumar AR, Joshi BN. Anti-diabetic Indian Plants: A Good Source of Potent Amylase Inhibitors. Evid Based Complement Alternat Med. 2011;2011:810207. doi:10.1093/ecam/nen040
64. Vijayanand S. Evaluation of Antidiabetic activity of Murraya koenigii on Alloxan Induced Diabetic rats. Int J Pharm Sci Res. 2015;6(12):1401-5.
65. Ahmed SK, Sunil M, Cheekavolu C, Alasyam N. Evaluation of anti-diabetic effect of Murraya koenigii leaves chloroform extract (MKLCE) in Alloxan induced diabetic albino rats. Pharm Innov J. 2017;6(11):474-7.
66. Palwankar SM, Kale PP, Kadu PK, Prabhavalkar K. Assessment of Anti-diabetic Activity of Combination of Murraya koenigii Leaves Extract and Vitis vinifera Seeds Extract in Alloxan-induced Diabetic Rats. J Rep Pharm Sci. 2020;9(1):79-85. doi:10.4103/jrptps.JRPTPS_50_19
67. Suman RK, Mohanty, IR, Borde MK, Deshmukh YA, Pathak A, Adhikari AK, et al. Evaluation of antidiabetic efficacy of Murraya koenigii on Streptozotocin induced diabetes in experimental rats. Int J Basic Clin Pharmacol. 2019;8(8):1906-10. doi:10.18203/2319-2003.ijbcp20193200
68. Yadav S, Vats V, Dhunnoo Y, Grover JK. Hypoglycemic and antihyperglycemic activity of Murraya koenigii leaves in diabetic rats. J Ethnopharmacol. 2002;82(2-3):111-6. doi:10.1016/S0378-8741(02)00167-8
69. Husna F, Suyatna FD, Arozal W, Poerwaningsih EH. Anti-Diabetic Potential of Murraya Koenigii (L.) and its Antioxidant Capacity in Nicotinamide-Streptozotocin Induced Diabetic Rats. Drug Res. 2018;68(11):631-6. doi:10.1055/a-0620-8210
70. Jing-Tian X, Wei-Tien C, Chong-Zhi W, Sangeeta RM, Jing Li, Ramalingam A, et al. Curry Leaf (Murraya koenigii Spreng.) Reduces Blood Cholesterol and Glucose Levels in ob/ob Mice. Am J Chin Med. 2006;34(2):279-84. doi:10.1142/S0192415X06003825
71. Widayanti A, Srifiana Y, Efendi K. Antidiabetics Activity of Koja Bay (Murraya koenigii) Leaves Tea Bag. Pharm Sci Res. 2019;6(2):107-10. doi:10.7454/psr.v6i2.4172
72. Tamilselvan, Muthamilselvi G. A True Experimental Study to Assess the Effectiveness of Curry Leaf Juice on Reduction of Blood Glucose Level among Patients with Diabetes mellitus at Selected Hospital, Puducherry. Int J Res Anal Rev. 2018;5(4):224 -32.
73. Jadhav KV, Dhudum BP. Effectiveness of Curry Leaves Powder on Blood Sugar Level among Diabetic Patients. Indian J Public Health Res Dev. 2019;10(7):388-93. doi:10.5958/0976-5506.2019.01597.3
74. Gaikwad V, Ray S. Effectiveness of curry leaves on blood sugar level among diabetic clients. Pharm Innov J. 2018;7(6):457-60.
75. Iyer UM, Mani UV. Studies on the effect of curry leaves supplementation (Murraya koenigi) on lipid profile, glycated proteins and amino acids in non-insulin-dependent diabetic patients. Plant Food Hum Nutr. 1990;40(4):275–82. doi:10.1007/BF02193851
2. Hu FB. Globalization of diabetes: the role of diet, lifestyle, and genes. Diabetes Care. 2011;34(6):1249-57. doi:10.2337/dc11-0442
3. Lin X, Xu Y, Pan X, Xu J, Ding Y, Sun X, et al. Global, regional, and national burden and trend of diabetes in 195 countries and territories: an analysis from 1990 to 2025. Sci Rep. 2020;10(1):14790. doi:10.1038/s41598-020-71908-9
4. Tran N, Pham B, Le L. Bioactive Compounds in Anti-Diabetic Plants: From Herbal Medicine to Modern Drug Discovery. Biology. 2020;9(9):252. doi:10.3390/biology9090252
5. Jacob B, Narendhirakannan RT. Role of medicinal plants in the management of diabetes mellitus: a review. 3 Biotech. 2019;9(1):4. doi:10.1007/s13205-018-1528-0
6. Kesari AN, Kesari S, Singh SK, Gupta RK, Watal G. Studies on the glycemic and lipidemic effect of Murraya koenigii in experimental animals. J Ethnopharmacol. 2007;112(2):305-11. doi:10.1016/j.jep.2007.03.023
7. Jain V, Momin M, Laddha K. Murraya Koenigii: An Updated Review. Int J Ayurvedic Herb Med. 2012;2(4):607-27.
8. Muthulinggam N, Partiban S. Murraya koenigii (curry leave)- A review on its potential. Int J PharmTech Res. 2015;7(4):566-72.
9. Saini SC, Reddy GBS. A Review on Curry Leaves (Murraya koenigii): Versatile Multi-Potential Medicinal Plant. Am J Phyto Clin Ther. 2015;3(4):363-8.
10. Saini SC, Reddy GBS. Murraya koenigii. IOSR J Pharm Biol Sci. 2013;7(6):15-8.
11. Muthumani P, Venkatraman S, Ramseshu K, Meera R, Devi P, Kameswari B, et al. Pharmacological studies of anticancer, anti-inflammatory activities of Murraya koenigii (Linn) Spreng in experimental animals. J Pharm Sci Res. 2009;1(3):137-41.
12. Debosree G, Firdaus SB, Mitra E, Dey M, Bandyopadhyay D. Protective effect of aqueous leaf extract of murraya koenigii against lead induced oxidative stress in rat liver, heart and kidney: a dose response study. Asian J Pharm Clin Res. 2012;5(Suppl 4):54–9.
13. Mittal J, Jain M, Gilhotra R, Singh RP. Curry leaf (Murraya koenigii): a spice with medicinal property. MOJ Biol Med. 2017;2(3):236-56. doi:10.15406/mojbm.2017.02.00050
14. Ito C, Itoigawa M, Nakao K, Murata T, Tsuboi M, Kaneda N, et al. Induction of apoptosis by carbazole alkaloids isolated from Murraya koenigii. Phytomedicine. 2006;13(5):359–65. doi:10.1016/j.phymed.2005.03.010
15. Iyer D, Uma Devi P. Phyto-pharmacology of Murraya koenigii (L.). Pharmacogn Rev. 2008;2(3):180-4.
16. Kureel SP, Kapil RS, Popli SP. Two novel alkaloids from Murraya koenigii spreng: mahanimbicine and bicyclomahanimbicine. Chem Ind. 1970;29:958.
17. Adebajo CA, Olugbade TA, Elujoba AA, Aladesanmi AJ, Reisch J. 2”, 3” Epoxyindicolactone from Murraya koenigii. Niger J Nat Prod Med. 1997; 1(1):21–4. doi:10.4314/njnpm.v1i1.11794
18. Handral HK, Jha PK, Shruthi SD. Pharmacognostic and phytochemical studies on the leaves of Murraya koenigii L Spreng. Pharmacophore. 2010;1(3):231-8.
19. Ajay S, Rahul S, Sumit G, Paras M, Mishra A, Gaurav A. Comprehensive review: Murraya koenigii Linn. Asian J Pharm Life Sci. 2011; 1(4):417-25.
20. Batool S, Khera RA, Hanif MA, Ayub MA, Memon S. Medicinal Plants of South Asia. Amsterdam: Elsevier; 2020. Chapter 14, Curry Leaf; p.179-90. doi:10.1016/B978-0-08-102659-5.00014-8
21. Abeysinghe DT, Alwis DDDH, Kumara KAH, Chandrika UG. Nutritive Importance and Therapeutics Uses of Three Different Varieties (Murraya koenigii, Micromelum minutum, and Clausena indica) of Curry Leaves: An Updated Review. Evid Based Complementary Altern Med. 2021;2021:5523252. doi:10.1155/2021/5523252
22. Joseph B, Jini D. Insight in to the hypoglycemic effect of Traditional Indian Herbs used in the Treatment of Diabetes. Res J Medicinal Plant. 2011;5(4):352-76. doi:10.17311/rjmp.2011.352.376
23. Matheka DM, Alkizim FO. Complementary and alternative medicine for type 2 diabetes mellitus: Role of medicinal herbs. J Diabetes Endocrinol. 2012;3(4):44-56. doi:10.5897/JDE12.008
24. Qais N, Jahan S, Shafiullah MS. A Review on Anti-diabetic Plants. Dhaka Univ J Pharm Sci. 2018;17(1):139-52. doi:10.3329/dujps.v17i1.37130
25. Thakur G, Pal K, Mitra A, Mukherjee S, Basak A, Rousseau D. Some Common Anti-diabetic Plants of the Indian Subcontinent. Food Rev Int. 2010;26(4):364-85. doi:10.1080/87559129.2010.496024
26. Handral HK, Pandith A, Shruthi SD. A Review on Murraya Koenigii: Multi potential Medicinal Plant. Asian J Pharm Clin Res. 2012;5(4):5-14.
27. Nouman SM, Shehzad A, Butt MS, Khan MI, Tanveer M. Phytochemical profiling of curry (Murraya koenijii) leaves and its health benefits. Pak J Food Sci. 2015;25(4):204-15.
28. Jacob B, Narendhirakannan RT. Role of medicinal plants in the management of diabetes mellitus: a review. 3 Biotech. 2019; 9:4. doi:10.1007/s13205-018-1528-0
29. Goel A, Sharma A, Kulshrestha S. A Phytopharmacological Review on Murraya koenigii: An Important Medicinal Plant. Int J Pharm Sci Rev Res. 2020;62(2):113-9.
30. Singh S. Omreb PK, Mohanc SM. Curry Leaves (Murraya koenigii Linn. Sprengal)- A Mircale Plant. Indian J Sci Res. 2014;4(1):46-52.
31. Singh J, Singh J, Kaur S. Herbal Interventions in Managing Diabetes Mellitus: A Review. Plant Arch. 2020;20(2):2781-91.
32. Singh AG. Murraya Koenigii (L.) Spreng-Curry Leaves/Mitho Nim - A Miracle Plant. Butwal Campus J. 2020; 3(1):125-30. doi:10.3126/bcj.v3i1.36515
33. Balakrishnan R, Vijayraja D, Jo SH, Ganesan P, Su-Kim I, Choi DK. Medicinal Profile, Phytochemistry, and Pharmacological Activities of Murraya koenigii and its Primary Bioactive Compounds. Antioxidants. 2020;9(2):101. doi:10.3390/antiox9020101
34. Katoch A, Batta B, Kumar A, Sharma PC. Screening of Murraya koenigii (Curry) and Camellia sinensis (Tea) leaves for antimicrobial activity against strains of Staphylococcus aureus, Pseudomonas aeruginosa and Candida species and their Phytochemical Analysis. Int J Pharm Sci Res. 2013;4(2);862-8. doi:10.13040/IJPSR.0975%2D8232.4(2).862%2D68
35. James SA, Omwirhiren R Efe M, Joshua IA, Dutse I. Anti-diabetic Properties and Phytochemical Studies of Ethanolic Leaf Extracts of Murraya Koenigii and Telfairia Occidentalis on Alloxan-Induced Diabetic Albino Rats. Adv Life Sci Technol. 2016;49:57-66.
36. Igara CE, Omoboyowa DA, Ahuchaogu AA, Orji NU, Ndukwe MK. Phytochemical and nutritional profile of Murraya Koenigii (Linn) Spreng leaf. J Pharmacogn Phytochem. 2016;5(5):7-9.
37. Arsha T, Rani MAS. Preliminary Phytochemical and Anatomical Studies on Bark and Leaves of Murraya koenigii (L.) Spreng.; (Family-Rutaceae) and Pimenta dioica (L.) Merr.; (Family-Myrtaceae). Int J Res Appl Sci Eng Tech. 2019;7(3):656-61.
38. Pande M, Ingale S, Gupta S. The Pharmacognostic and phytochemical studies on the leaves of Murraya koenigii (L) Spreng. Indian J Sci Technol. 2009;2(3):53-4. doi:10.17485/IJST/2009/V2I3/29415
39. Vats M, Singh H, Sardana S. Phytochemical screening and antimicrobial activity of roots of Murraya koenigii (Linn.) Spreng. (Rutaceae). Braz J Microbiol. 2011;42(4):1569-73. doi:10.1590/s1517-838220110004000044
40. Garg D, Muley A, Khare N, Mara T. Comparative Analysis of Phytochemical Profile and Antioxidant Activity of Some Indian Culinary Herbs. Res J Pharm Biol Chem Sci. 2012;3(3):845-54.
41. Abubakar NA, Oise AE, Saidu AN. Phytochemical Constituents and Hypoglycemic Effect of Aqueous and Ethanolic Extracts of Murraya Koenigii in Alloxan-Induced Diabetic Rats. IOSR J Dent Med Sci. 2014;13(9):8-12.
42. Kumar NS, Simon N. In-vitro Antimicrobial Activity and Phytochemical Analysis of Murraya koenigii (L) Leaf Extracts. Glob J Sci Front Res C Biol Sci. 2016;16(1):29-32.
43. Thangavel A, Sahu O, Ponnappan S, Tadele A, Abawa G, Karthikeyan M. Evaluation of Preliminary Phytochemical Constituents and Antibacterial Activity of Edible Plants against Urinary tract causing Bacteria in Children. J Clin Microbiol Biochem Technol. 2017;3(2):24-30.
44. Anjaneyulu N, Alla T, Reddy SN, Ravali AS, Nikitha G, Srividhya PV, et al. Phytochemical Studies and Qualitative Analysis by TLC of Murraya Koenigii Bark Extract. Indo Am J Pharm Sci, 2017;4(4):904-9.
45. Jelita, Wirjosentono B, Tamrin, Marpaung L. Phytochemical Screening and Chemical Analysis of Ethanol Extract of Kari Leaves (Murayya koeginii) Using GC-MS Method. International Conference on Education, Science and Technology, J Phys Conf Series. 2019;1232:012012.doi:10.1088/1742-6596/1232/1/012012
46. Deepika T, Noorjahan CM. Phytochemical Screening and Antioxidant Property of Aqueous Murraya Koenigii (Curry Leaf) Extract. Int J Res Advent Technol. 2019;7(2):738-43.
47. Sharma R, Kumar U. Exploration and Phytochemical estimation of Murraya koenigii Leaves for Pharmaceutical Applications. Asian J Pharm Res. 2019;9(3):159-68. doi:10.5958/2231-5691.2019.00025.X
48. Sophiyamole L, Reshma JK, Prabhachandh RS, Babychan N. Phytochemical Analysis of Murraya Koenigii in Urban and Coastal Area. J Emerg Technol Innov Res. 2017;4(10):238-40.
49. Rajendran MP, Pallaiyan BB, Selvaraj N. Chemical composition, antibacterial and antioxidant profile of essential oil from Murraya koenigii (L.) leaves. Avicenna J Phytomed. 2014;4(3):200-14.
50. Ali G, Hawa ZEJ, Asmah R, Thiyagu D. Evaluation of Bioactive Compounds, Pharmaceutical Quality, and Anticancer Activity of Curry Leaf (Murraya koenigii L.). Evid Based Complementary Altern Med., 2014;2014:873803. doi:10.1155/2014/873803
51. Vinayagam R, Xiao J, Xu B. An insight into anti-diabetic properties of dietary phytochemicals. Phytochem Rev. 2017;16:535–53. doi:10.1007/s11101-017-9496-2
52. Aba PE, Asuzu IU. Mechanisms of actions of some bioactive anti-diabetic principles from phytochemicals of medicinal plants: A review. Indian J Nat Prod Resour. 2018;9(2):85-96.
53. Vinuthan MK, Girishkumar V, Ravindra, Jayaprakash JP, Narayana K. Effect of extracts of Murraya Koenigii leaves on the levels of blood glucose and plasma insulin in alloxan induced diabetic rats. Indian J Physiol Pharmacol. 2004;48(3):348–52.
54. Phatak RS, Khanwelkar CC, Matule SM, Datkhile KD, Hendre AS. Antihyperglycemic Activity of Murraya koenigii Leaves Extract on Blood Sugar Level in Streptozotocin-Nicotinamide Induced Diabetes in Rats. Biomed Pharmacol J. 2019;12(2):597-602. doi:10.13005/bpj/1679
55. Arulselvan P, Senthilkumar GP, Kumar DS, Subramanian S. Anti-diabetic effect of Murraya koenigii leaves on streptozotocin induced diabetic rats. Pharmazie. 2006;61:874–7.
56. Fauziah, Nindya NP, Firdus. The Effect of Curry Leaves (Murayya Koenigii L.) on Blood Glucose Levels in Alloxan Diabetic Mice (Mus Musculus). J Natural. 2014;14(1):23-9.
57. Lawal HA, Atiku MK, Khelpai DG, Wannan NN. Hypoglycaemic and hypolipidaemic effects of the aqueous leaf extract of Murraya koenigii in normal and alloxan – diabetic rats. Niger J Physiol Sci. 2008;23(1-2):37-40. doi:10.4314/njps.v23i1-2.54919
58. Tembhurne SV, Sakarkar DM. Anti-obesity and hypoglycemic effect of ethanolic extract of Murraya koenigii (L) leaves in high fatty diet rats. Asian Pac J Trop Dis. 2012;2(Suppl 1):S166-8. doi:10.1016/S2222-1808(12)60145-5
59. Sudha MJ, Viveka S, Rai M. Study of Hypoglycemic Effect of Murraya koenigii leaf extracts In Streptozotocin Induced Diabetic Rats. Int J Med Appl Sci. 2013;2(3):191-9.
60. Al-Ani IM, Santosa RI, Yankuzo MH, Saxena AK, Alazzawi KS. The Antidiabetic Activity of Curry Leaves “Murraya Koenigii” on the Glucose Levels, Kidneys, and Islets of Langerhans of Rats with Streptozotocin Induced Diabetes. Makara J Health Res. 2017;21(2):54-60. doi:10.7454/msk.v21i2.7393
61. El-Amin M, Virk P, Elobeid MA, Almarhoon ZM, Hassan ZK, Omer SA, et al. Anti-diabetic effect of Murraya koenigii (L) and Olea europaea (L) leaf extracts on streptozotocin induced diabetic rats. Pak J Pharm Sci. 2013;26(2):359-65.
62. Desai RR, Khanwelkar CC, Gidamudi S, Phatak RS, Jadhav S, Thorat, V, et al. Antidiabetic effect of Murraya koenigii leaves aqueous extract on blood sugar levels in alloxanized diabetic rats. Pravara Med Rev. 2019;11(2):19-24.
63. Bhat M, Zinjarde SS, Bhargava SY, Kumar AR, Joshi BN. Anti-diabetic Indian Plants: A Good Source of Potent Amylase Inhibitors. Evid Based Complement Alternat Med. 2011;2011:810207. doi:10.1093/ecam/nen040
64. Vijayanand S. Evaluation of Antidiabetic activity of Murraya koenigii on Alloxan Induced Diabetic rats. Int J Pharm Sci Res. 2015;6(12):1401-5.
65. Ahmed SK, Sunil M, Cheekavolu C, Alasyam N. Evaluation of anti-diabetic effect of Murraya koenigii leaves chloroform extract (MKLCE) in Alloxan induced diabetic albino rats. Pharm Innov J. 2017;6(11):474-7.
66. Palwankar SM, Kale PP, Kadu PK, Prabhavalkar K. Assessment of Anti-diabetic Activity of Combination of Murraya koenigii Leaves Extract and Vitis vinifera Seeds Extract in Alloxan-induced Diabetic Rats. J Rep Pharm Sci. 2020;9(1):79-85. doi:10.4103/jrptps.JRPTPS_50_19
67. Suman RK, Mohanty, IR, Borde MK, Deshmukh YA, Pathak A, Adhikari AK, et al. Evaluation of antidiabetic efficacy of Murraya koenigii on Streptozotocin induced diabetes in experimental rats. Int J Basic Clin Pharmacol. 2019;8(8):1906-10. doi:10.18203/2319-2003.ijbcp20193200
68. Yadav S, Vats V, Dhunnoo Y, Grover JK. Hypoglycemic and antihyperglycemic activity of Murraya koenigii leaves in diabetic rats. J Ethnopharmacol. 2002;82(2-3):111-6. doi:10.1016/S0378-8741(02)00167-8
69. Husna F, Suyatna FD, Arozal W, Poerwaningsih EH. Anti-Diabetic Potential of Murraya Koenigii (L.) and its Antioxidant Capacity in Nicotinamide-Streptozotocin Induced Diabetic Rats. Drug Res. 2018;68(11):631-6. doi:10.1055/a-0620-8210
70. Jing-Tian X, Wei-Tien C, Chong-Zhi W, Sangeeta RM, Jing Li, Ramalingam A, et al. Curry Leaf (Murraya koenigii Spreng.) Reduces Blood Cholesterol and Glucose Levels in ob/ob Mice. Am J Chin Med. 2006;34(2):279-84. doi:10.1142/S0192415X06003825
71. Widayanti A, Srifiana Y, Efendi K. Antidiabetics Activity of Koja Bay (Murraya koenigii) Leaves Tea Bag. Pharm Sci Res. 2019;6(2):107-10. doi:10.7454/psr.v6i2.4172
72. Tamilselvan, Muthamilselvi G. A True Experimental Study to Assess the Effectiveness of Curry Leaf Juice on Reduction of Blood Glucose Level among Patients with Diabetes mellitus at Selected Hospital, Puducherry. Int J Res Anal Rev. 2018;5(4):224 -32.
73. Jadhav KV, Dhudum BP. Effectiveness of Curry Leaves Powder on Blood Sugar Level among Diabetic Patients. Indian J Public Health Res Dev. 2019;10(7):388-93. doi:10.5958/0976-5506.2019.01597.3
74. Gaikwad V, Ray S. Effectiveness of curry leaves on blood sugar level among diabetic clients. Pharm Innov J. 2018;7(6):457-60.
75. Iyer UM, Mani UV. Studies on the effect of curry leaves supplementation (Murraya koenigi) on lipid profile, glycated proteins and amino acids in non-insulin-dependent diabetic patients. Plant Food Hum Nutr. 1990;40(4):275–82. doi:10.1007/BF02193851
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1.
Sanmugarajah V, Rajkumar G. A Review of Anti-hyperglycemic Effects of Curry Leaf Tree (Murraya koenigii). Borneo J Pharm [Internet]. 2022May31 [cited 2024Dec.21];5(2):104-1. Available from: https://journal.umpr.ac.id/index.php/bjop/article/view/3300
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